DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and clumsy

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	116/493 - (23%)
Similarity:	184/493 - (37%)	Gaps:	130/493 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 QKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVE 268
            ||..|  .|:::..|       :|:..||.:.|..|  |.|..:.:.:..      :..|...:.
  Fly   410 QKLSN--KTFIVSSR-------LGAPFLTLREPQEG--EILTGNSRYEGY------SIDLINEIA 457

  Fly   269 RMFNLSLAISLT--DKWGELLD-NGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQ 330
            :|.|......::  .|:|.|.. ..:|.|::.|:....||..:|.:.....|:..|.::....|.
  Fly   458 KMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTL 522

  Fly   331 NIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTI----LLLFHVRLERML--------- 381
            .|..||..|........ |..|.|..||     :..||..    ||||  .|.||.
  Fly   523 GISILFSKPPTPPTDLFSFLSPFSLDVW-----IYMGSAYLFISLLLF--ALARMAPDDWENPHP 580

  Fly   382 ----SNMENRFSFVWFTMLETYLQ----QGPANEIF-RLFSTRLLISLSCIFSFMLMQFY----G 433
                ..:||    :|..|..|:|.    .|...:|. :..||||:..:...|:.|::..|    .
  Fly   581 CKEPEEVEN----IWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLA 641

  Fly   434 AFIVGSLLSESARSIVNLQA-----------------LYDSNLA------IGMENISYNFPIFTN 475
            ||:..|..:.|..|..:|.|                 ..|||.:      ..||:.|.:  :||.
  Fly   642 AFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPS--VFTK 704

  Fly   476 TSNQLVRDVYVKKICKSGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCD 537
            |::                       :|.||:.:|:        .:|..|:|   |:.:....||
  Fly   705 TND-----------------------EGVERVQKGK--------NLYAFLMESTTLEYNVERKCD 738

  Fly   538 LQEVMFNLPYDS-GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKW---MVRRPDCSLFKTSQ- 597
            |.::...|.|.| |..||..||:|:.::.|:|.....|.|....:||   |....:|.  |:.:
  Fly   739 LVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCE--KSDED 801

  Fly   598 ----AEVDLEHFAPALFALALAMVASALVFLLELFLHW 631
                .|:.||:.......|.|.:: ||:|.....|| |
  Fly   802 GGDTPELGLENVGGVFLVLGLGLL-SAMVLGCTEFL-W 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	95/417 (23%)
		Lig_chan	355..602	CDD:278489	72/307 (23%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377
		ANF_receptor	39..379	CDD:279440
		PBP2_iGluR_Kainate	414..787	CDD:270432	100/433 (23%)
		Lig_chan	548..812	CDD:278489	73/309 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940