DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and GluRIIB

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	149/773 - (19%)
Similarity:	262/773 - (33%)	Gaps:	203/773 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KLQVKVISWPLIILTAFLRVLQIESINTNFLELAAFEDFLRSEH---LSHVLV------------ 52
            :|.|.|....|.:..||..:|..::.:.....:|    :.||.|   |.|:|.
  Fly   129 QLTVNVAPMELFLSAAFSDILASKTFDWKSFTIA----YERSSHLIRLQHILAWKQLHKAGIKMQ 189

  Fly    53 --VRGDDADGDWK-----------IECHQKLLANYRVQFYRPEMSANFEDLM------------- 91
              .||||....||           ::|...:|.:.........|:.:|..|.
  Fly   190 EFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDG 254

  Fly    92 FYGSPRTAVLVLNSEHVLVRRQV-FGVASEAGYFNNSL--AWFILGS------------------ 135
            ||....|..:..    |.:|..| ..|..|...|:||:  .:..|||
  Fly   255 FYSRDFTVAVAA----VRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEIS 315

  Fly   136 ------------GRES-LPVEQLIDQL-----------LSGYRMGIDADITVALRGPDNASMLFY 176
                        ||.. .|..:|::|:           ....|:.|:||   ..|...|     .
  Fly   316 QRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINAD---GQREDFN-----L 372

  Fly   177 DVYRISRQANTPLIIEKKGLWTHSGGYQKFGNFK--NTWVIRRRNFLN-------------VTLI 226
            :||       .|:|.....:|........|...:  :|..::::...|             .|.:
  Fly   373 EVY-------NPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRV 430

  Fly   227 GSTVLT--EKPPGFGDMEYLADDK-QLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGEL-L 287
            |....:  |:|.|   :.|..::: :...:|.:    |.|.|  |..|:.:......:|:|.. .
  Fly   431 GKPYFSWREEPEG---VHYEGNERFEGYAVDLI----YMLAQ--ECKFDFNFEPVRDNKYGSYDA 486

  Fly   288 DNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFL-FRHPRRSHIKNIFFEP 351
            :...|.|::.|:....|...:|.:.....|:..|.::.......|..| ::.|........|..|
  Fly   487 NTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNP 551

  Fly   352 LSNQVWWCVLALVTGSTILLLFHVRLERM-------LSNMENRFSFVW------FTMLETYLQQG 403
            .:.:||..|:..:..:...|:|..|:::.       ..|.|.....:|      :.:|.:.|.||
  Fly   552 YNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQG 616

  Fly   404 PANEIFRLFSTRLLISLSCIFSFMLMQFY----GAFIVGSLLSESARSIVNLQALYDSNL----A 460
             .:.:.|....|||.:...||:.::.|.|    .|||..|.:   |..|.:|..|.|.|.    .
  Fly   617 -CDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKI---AGDIGSLHDLVDQNKVQFGT 677

  Fly   461 IGMENISYNFPIFTNTSNQLV--------RDVYVKKICKSGEHNIMSLQQGAERI--IQGRFAFH 515
            |.....|..|....:|.|::.        .|.:.|           :.::|.:|:  .:|.:||
  Fly   678 IRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTK-----------NNEEGVDRVKLSKGTYAF- 730

  Fly   516 TAIDRMYRLLLE---LQMDEAEFCDLQEV--MFNLPYDSGSVMPKGSPWREHLAHALLHFRATGL 575
                     |:|   ||......|:|.::  .|...: .|..:|..:.:|.:|:..:|.....|.
  Fly   731 ---------LMETTNLQYYVQRNCELTQIGESFGEKH-YGIAVPLNADFRSNLSVGILRLSERGE 785

  Fly   576 LQYNDKKWMVRRP---DCSLFKTSQAEVDLEHFAPALFALALAMVASALVFLLELFLH 630
            |.....||.....   |.::......:.|::........|.:.:|...::.:.|...|
  Fly   786 LFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWH 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	15/81 (19%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	84/414 (20%)
		Lig_chan	355..602	CDD:278489	60/285 (21%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	55/286 (19%)
		ANF_receptor	41..378	CDD:279440	52/271 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	85/407 (21%)
		Lig_chan	555..822	CDD:278489	61/292 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940