DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and GluRIIE

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	146/747 - (19%)
Similarity:	260/747 - (34%)	Gaps:	187/747 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TNFLELAAFEDFLRSEHLSHVLVVRGDDADGDWKIECHQKLLANYRVQFYRPEMSANFEDLMFYG 94
            |.|:.|....::|..  |:.:..:.|........:....:|..||:....|...|.: ..::..|
  Fly   159 TRFIFLYESAEYLNI--LNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVD-NRIVVVG 220

  Fly    95 SPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGS------------------------ 135
            |..|....||.            |.:.|..|.... :|:|:
  Fly   221 SSETMPEFLNQ------------AQQVGIINEDYK-YIIGNLDFHSFDLEEYKYSEANITGLRLF 272

  Fly   136 GRESLPVEQLIDQLLSGYRMGID------ADITVALRGPDNASMLFYDVYRISRQA--NTPLIIE 192
            ..|.:.|::|:.:|  ||....|      ..|||.:       .|.||..::..|.  |.|....
  Fly   273 SPEKMAVKELLMKL--GYPTDQDEFRNGSCPITVEM-------ALTYDAVQLFAQTLKNLPFKPM 328

  Fly   193 KKGLWTHSGGYQKFG-NFKNTWVIRRRNFLNVTLIGS-------------TVLTEKPPGFGDMEY 243
            .:.....:...:..| :|||  .:|.....:..|.|.             .|:..:|.|...:..
  Fly   329 PQNCSQRTESVRDDGSSFKN--YMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKVGT 391

  Fly   244 LADDKQL--QQLDP-----------MQRKTYQLF---------QLVERM-----------FNLSL 275
            ..:|:|.  |:|.|           :..||:.:.         ||||..           :.:.|
  Fly   392 WDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDL 456

  Fly   276 AISLTDKWGELL-------DNGSW-------SGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAV 326
            ...|.||.|...       |.||:       :|::.::.:..||.|:..:....:|:..:.::..
  Fly   457 IKELADKLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIP 521

  Fly   327 LHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLE-----------R 379
            .....|..|:..|:::..:.. |.:|.|.:|||.:.....|.::......||.           .
  Fly   522 FMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIE 586

  Fly   380 MLSNMENRFSF---VWFTMLETYLQQGPANEIF-RLFSTRLLISLSCIFSFMLMQFYGAFIVGSL 440
            ....:||:|:.   :||| ....||||  :||. :..|||.:.|....|:.:::..|.|.:...|
  Fly   587 EPEELENQFTLGNSIWFT-TGALLQQG--SEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFL 648

  Fly   441 LSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLV--RDVYVKKICKSGEHNIMSL--- 500
            ..|..:|::|..    .:||...:.:.|......:|.|..:  .:...||:.|....|...|
  Fly   649 TIEKPQSLINSV----DDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTED 709

  Fly   501 -QQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCDLQEVMFNLPYDS-GSVMPKGSPWR 560
             .:|..|:         ..:..|..|:|   ::.:....|:|:::...|.... |..|.|..|.|
  Fly   710 NMEGVNRV---------KTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHR 765

  Fly   561 EHLAHALLHFRATGLLQYNDKKWMVR-----------RPDCSLFKTSQAEVDLEHFAPALFALAL 614
            ....:|||..:..|:|:....||...           .||.:       .:|:.:.....|.|.:
  Fly   766 GKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDAT-------PLDMNNLEGVFFVLLV 823

  Fly   615 AM-------VASALVFLLELFLHWLPDFRRRL 639
            ..       :.|.::|:::...|:....|..|
  Fly   824 GSCCALLYGIISWVLFVMKKAHHYRVPLRDAL 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	11/57 (19%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	92/446 (21%)
		Lig_chan	355..602	CDD:278489	61/282 (22%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	47/263 (18%)
		ANF_receptor	51..382	CDD:279440	45/249 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	84/386 (22%)
		Lig_chan	551..824	CDD:278489	64/295 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940