DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and Nmdar2

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	144/769 - (18%)
Similarity:	261/769 - (33%)	Gaps:	236/769 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ELAAFEDFLRS---------EH-----LSHVLVVRGDDADGDWKIECHQKLLANYRVQFYRPEMS 84
            ::|..:||:::         ||     |:.::|.|..|.     :|     |.|...:.
  Fly   261 QIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDL-----ME-----LVNSEARV------ 309

  Fly    85 ANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGS------GRESLPVE 143
                 ::.|.:...|:.:|.:            |.|......:..|.:..|      .....||.
  Fly   310 -----MLLYATQTEAITILRA------------AEEMKLTGENYVWVVSQSVIEKKDAHSQFPVG 357

  Fly   144 QL--------------IDQLLSGYRMGIDADITVAL-----------------RGP-DNASMLFY 176
            .|              |...:..|..|::|.:|...                 ||. ||..:.|.
  Fly   358 MLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFK 422

  Fly   177 DVYRIS------------------RQA------------NTPLIIEKKGLWTHSGGYQKFGNFKN 211
            .:..:|                  |.|            |..|:.|:.|:|             .
  Fly   423 YLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVW-------------K 474

  Fly   212 TWVIRRRNFLNVTLIGS----------------TVLTEKP--------PGFG----DMEYL---- 244
            :|..::.:..::...|:                |.|.|.|        |..|    |...|
  Fly   475 SWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVA 539

  Fly   245 ADDKQLQQLDPMQRKTYQLF---------QLVERM-----FNLSLAISLTDKWGELLDNGSWSGV 295
            ||.:....:|..|....:.|         .|:|:.     |...|......||| .|:||.|:|:
  Fly   540 ADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWG-TLENGKWNGL 603

  Fly   296 MGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHI--KNIFFEPLSNQVWW 358
            :..:.:|:.|..:..:....:|:..|.:|.......|..:.  .:|:.|  ...|.||.....|.
  Fly   604 IADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVV--AKRTGIISPTAFLEPFDTASWM 666

  Fly   359 CV--LALVTGSTILLLFH--------VRLERMLSNM-ENRFS------FVWFTMLETYLQ-QGPA 405
            .|  :|:...:.::.||.        ::|....:|: ..|||      .||..:.:..:. ..|
  Fly   667 LVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSP- 730

  Fly   406 NEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIGMEN-ISYN 469
                |.|::|.:.::..:|:.:.:..|.|.:...:::.  ........|.||.|.....: .|:.
  Fly   731 ----RGFTSRFMTNVWALFAVVFLAIYTANLAAFMITR--EEFHEFSGLNDSRLVHPFSHKPSFK 789

  Fly   470 FPI--FTNTSNQL-----VRDVYVKKICKSGEHNIMSLQQGAERIIQGR---FAFHTAIDRMYRL 524
            |..  :::|.:.:     |...|::      ::|..|:..|...::.|.   |.:...:
  Fly   790 FGTIPYSHTDSTIHKYFNVMHNYMR------QYNKTSVADGVAAVLNGNLDSFIYDGTV------ 842

  Fly   525 LLELQMDEAEFCDLQEV-MFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVR-- 586
             |:..:.:.|.|.|..| .:......|....:.|.:.:.....||.|||.|.|:...:.||..
  Fly   843 -LDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTC 906

  Fly   587 RPDCSLFKTSQAEVDLEHFAPALFALALAMVASALVFLLE-LFLHWLPDFRRRL 639
            ||.....|:|. .:.||.|..|...|...::.:||:.||| ::..::   |:||
  Fly   907 RPGKQEHKSSD-PLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYI---RKRL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	8/57 (14%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	84/438 (19%)
		Lig_chan	355..602	CDD:278489	53/278 (19%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	41/274 (15%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	85/428 (20%)
		Lig_chan	665..928	CDD:278489	56/283 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940