DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and Grik3

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	139/669 - (20%)
Similarity:	254/669 - (37%)	Gaps:	129/669 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IILTAFLRVLQIESINTNFLELAAFEDF-LRSEHLSHVLVVRGDDADGDWKIECHQKLLANYRVQ 77
            |..|..|..|.:|....:.:.|..|... :.:.|:|.::        ..|.:|   :|.|..|.:
  Rat   258 IFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIV--------EKWSME---RLQAAPRAE 311

  Fly    78 FYRPEMSANFEDLMFYGSPRTAVLVLNSEHVL----VRRQVFGVAS------EAGYFNNSLAWFI 132
                  |...:.:|.    ..|.|:.::.|::    .|.....|.|      :|..|......||
  Rat   312 ------SGLLDGVMM----TDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFI 366

  Fly   133 LGSGRESLPVEQLIDQLLSGYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLW 197
            ..:..|.| ..:::....||.|...|.|| ::|:...                     :||.|:|
  Rat   367 KEAQWEGL-TGRIVFNKTSGLRTDFDLDI-ISLKEDG---------------------LEKVGVW 408

  Fly   198 THSGGYQKFGNFKNTWVIRRR------NFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPM 256
            :.:.|      ...|.|.:.|      :..|.:||.:|:| |:|    .:.:...|:.|...|..
  Rat   409 SPADG------LNITEVAKGRGPNVTDSLTNRSLIVTTLL-EEP----FVMFRKSDRTLYGNDRF 462

  Fly   257 QRKTYQLFQLVERMFNLSLAISLTD--KWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQP 319
            :.....|.:.:..:...|..|.|.:  |:|...|.|.|:|::.::...:||.||.|:.....|:.
  Rat   463 EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREK 527

  Fly   320 YVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERM--- 380
            .:.:|....|..:..|:|.|..::.... |..|||..:|..||....|.:.:|....|....
  Rat   528 AIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY 592

  Fly   381 --------LSNMENRFSFV---WFTMLETYLQQGPANEIF-RLFSTRLLISLSCIFSFMLMQFYG 433
                    ...:||.|:.:   ||.| .:.:|||  :|:. :..|||::..:...|:.:::..|.
  Rat   593 DAHPCNPGSEVVENNFTLLNSFWFGM-GSLMQQG--SELMPKALSTRIIGGIWWFFTLIIISSYT 654

  Fly   434 AFIVGSLLSESARSIVNL--QALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYV------KKIC 490
            |.:...|..|...|.::.  .....:.:..|..........|..:.......::.      ..:.
  Rat   655 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALV 719

  Fly   491 KSGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCDLQEV---MFNLPYDS 549
            |:.|       :|.:|.:...:|          ||:|   ::......|:|.::   :.:..|..
  Rat   720 KNNE-------EGIQRTLTADYA----------LLMESTTIEYITQRNCNLTQIGGLIDSKGYGI 767

  Fly   550 GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE-VDLEHFAPALFALA 613
            |:  |.|||:|:.:..|:|..:....|....:||. |...|...:..:|. :.::........||
  Rat   768 GT--PMGSPYRDKITIAILQLQEEDKLHIMKEKWW-RGSGCPEEENKEASALGIQKIGGIFIVLA 829

  Fly   614 LAMVASALVFLLELFLHWL 632
            ..:|.|.||.:.| |::.|
  Rat   830 AGLVLSVLVAVGE-FIYKL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	10/61 (16%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	82/392 (21%)
		Lig_chan	355..602	CDD:278489	52/276 (19%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	40/208 (19%)
		ANF_receptor	55..398	CDD:279440	34/162 (21%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	84/395 (21%)
		Lig_chan	564..832	CDD:278489	54/290 (19%)
		Glutamate binding	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840