DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and GRIN2C

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_016880033.1	Gene:	GRIN2C / 2905	HGNCID:	4587	Length:	1337	Species:	Homo sapiens

Alignment Length:	542	Identity:	107/542 - (19%)
Similarity:	193/542 - (35%)	Gaps:	143/542 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 EKKGLWTHSGGYQKFGNFKNTW---------VIRRRNFLNVTLIGST-VLTEKP-PGFGDMEYLA 245
            |..|.|.|...|.|:    ..|         |:..|:....||.... |:.|.| ||.|..
Human   445 EMVGRWEHGVLYMKY----PVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGC---- 501

  Fly   246 DDKQLQQLDPMQRKTYQLF------------------QLVERM-----FNLSLAISLTDKWGELL 287
                :....|.:|::...|                  .:::::     |:..|.:....|.|:.:
Human   502 ----VPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRV 562

  Fly   288 DNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPL 352
             .|.|:|::|:|..:.||.|:..:....:|...|.:|.......|..:......:...:.|.||.
Human   563 -RGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPY 626

  Fly   353 SNQVWWCVLALVTGSTILLLFHVRLERMLSNMENRFSFVWFTMLETYLQQ--------GPA---- 405
            |..||  |:..|...|::.:             ..|.|.:|:.: :|.|.        |||
Human   627 SPAVW--VMMFVMCLTVVAI-------------TVFMFEYFSPV-SYNQNLTRGKKSGGPAFTIG 675

  Fly   406 NEIFRLF----------------STRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQAL 454
            ..::.|:                ::::::.:...|:.:.:..|.|.:...::.|  :.|..:..|
Human   676 KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE--QYIDTVSGL 738

  Fly   455 YDSNLAIGMENIS-----------------------YNFPIFTNTSNQL-----VRDVY---VKK 488
            .|.. ::.:||..                       :.|....|.|.:.     .||::   ||.
Human   739 SDKK-SLHLENTGVAWTAFKTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKF 802

  Fly   489 ICKSGEHNIMSLQQGAERIIQGR----FAFHTAIDRMYRLLLELQMDEAEFCDL-----QEVMFN 544
            ..:|.|..:.||:.|:|.....|    |.:..|:       |.....:.|.|.|     .:|...
Human   803 NQRSVEDALTSLKMGSEAQPVPRKLDAFIYDAAV-------LNYMAGKDEGCKLVTIGSGKVFAT 860

  Fly   545 LPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLEHFAPAL 609
            ..|  |..|.|.|.|:..:..|||.|...|..|..:..|:.........:...:::|:::.|...
Human   861 TGY--GIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVF 923

  Fly   610 FALALAMVASALVFLLELFLHW 631
            :.|.:||..:.|||..|..::|
Human   924 YMLLVAMGLALLVFAWEHLVYW 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	87/453 (19%)
		Lig_chan	355..602	CDD:278489	57/314 (18%)
GRIN2C	XP_016880033.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840