DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and GRIK4

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	718	Identity:	146/718 - (20%)
Similarity:	265/718 - (36%)	Gaps:	205/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KIEC---HQKLLANYRVQFYRPEMSANFED--------LMFYGSPRTAVLVLN-----SEHVLVR 111
            |.||   .:|||..:.:.  :..:|....|        |......:||.::::     |..:|::
Human   168 KAECLLNLEKLLRQFLIS--KDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLK 230

  Fly   112 RQVFGVASE--------------------------AGY--FNNSLAWFILGSGRESLPVEQLIDQ 148
            ....|:.|.                          .|:  ||.|.|:|           ::....
Human   231 AAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFF-----------QEFAQS 284

  Fly   149 LLSGYRMGIDADITVALRGPDNASMLFYD--------VYRISR-----------------QANTP 188
            |...::...|   .|...||..:|.|.:|        |..::|                 |..|.
Human   285 LNQSWQENCD---HVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTS 346

  Fly   189 L-----IIEKKGLWTH--------------------SGGYQKFG-----------------NFKN 211
            |     ::|.:||..|                    ..|:::.|                 |..:
Human   347 LMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISD 411

  Fly   212 TWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLF------QLVERM 270
            |       ..|.||:.:|:| |.|       ||......|:::...|  |:.|      :|.|.:
Human   412 T-------LFNTTLVVTTIL-ENP-------YLMLKGNHQEMEGNDR--YEGFCVDMLKELAEIL 459

  Fly   271 -FNLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHF 334
             ||..:.:.....:|....||:|:|::|::.:|:||.||..:....:|:..:.:|....|..|..
Human   460 RFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISI 524

  Fly   335 LFR-HPRRSHIKNIFFEPLSNQVW-WCVLALVTGSTILLLF-----------HVRLERMLSNMEN 386
            |:| |..|......|.:|.|..|| :.:||.:..|.:|.|.           |...:...:.:.|
Human   525 LYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVN 589

  Fly   387 RFSF---VWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSES 444
            ::|.   :||. :..::|||    |     |..|||.:..:...|:.:::..|.|.:...|..:
Human   590 QYSLGNSLWFP-VGGFMQQGSTIAP-----RALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQ- 647

  Fly   445 ARSIVNLQALYD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIMSLQQGAE 505
             |..|.::::.|    :.:..|..:...:...|.|:..|..:.::.....|.....:.|.::|..
Human   648 -RMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIA 711

  Fly   506 RIIQGRFAFHTAIDRMYRLLLELQMDE---AEFCDLQEV---MFNLPYDSGSVMPKGSPWREHLA 564
            |::...:||          |||..|:|   ...|:|.::   :....|..|  ||.||.:|:...
Human   712 RVLNSNYAF----------LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIG--MPVGSVFRDEFD 764

  Fly   565 HALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE-VDLEHFAPALFALALAMVASALVFLLELF 628
            .|:|..:....|:...:||. ....|...:..:|: :.:|:.......|...::.:..:.:|| |
Human   765 LAILQLQENNRLEILKRKWW-EGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE-F 827

  Fly   629 LHW 631
            | |
Human   828 L-W 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	13/64 (20%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	93/397 (23%)
		Lig_chan	355..602	CDD:278489	58/276 (21%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	40/247 (16%)
		ANF_receptor	43..382	CDD:279440	38/229 (17%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	95/400 (24%)
		Lig_chan	547..816	CDD:278489	60/289 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940