Protein Alignment Ir84a and GRIK3

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 137/659 - (20%)
• Similarity: 246/659 - (37%)
• Gaps: 128/659 - (19%)

  Fly    14 IILTAFLRVLQIESINTNFLELAAFEDF-LRSEHLSHVLVVRGDDADGDWKIECHQKLLANYRVQ 77
            |..|..|..|.:|....:.:.|..|... :.:.|:|.::        ..|.:|         |:|
Human   258 IFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIV--------EKWSME---------RLQ 305

  Fly    78 FYRPEMSANFEDLMFYGSPRTAVLVLNSEHVL----VRRQVFGVAS------EAGYFNNSLAWFI 132
            ......|...:.:|.    ..|.|:.::.|::    .|.....|.|      :|..|......||
Human   306 AAPRSESGLLDGVMM----TDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFI 366

  Fly   133 LGSGRESLPVEQLIDQLLSGYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLW 197
            ..:..|.| ..:::....||.|...|.|| ::|:...                     :||.|:|
Human   367 KEAQWEGL-TGRIVFNKTSGLRTDFDLDI-ISLKEDG---------------------LEKVGVW 408

  Fly   198 THSGGYQKFGNFKNTWVIRRR------NFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPM 256
            :.:.|      ...|.|.:.|      :..|.:||.:||| |:|    .:.:...|:.|...|..
Human   409 SPADG------LNITEVAKGRGPNVTDSLTNRSLIVTTVL-EEP----FVMFRKSDRTLYGNDRF 462

  Fly   257 QRKTYQLFQLVERMFNLSLAISLTD--KWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQP 319
            :.....|.:.:..:...|..|.|.:  |:|...|.|.|:|::.::...:||.||.|:.....|:.
Human   463 EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREK 527

  Fly   320 YVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERM--- 380
            .:.:|....|..:..|:|.|..::.... |..|||..:|..||....|.:.:|....|....
Human   528 AIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY 592

  Fly   381 --------LSNMENRFSFV---WFTMLETYLQQGPANEIF-RLFSTRLLISLSCIFSFMLMQFYG 433
                    ...:||.|:.:   ||.| .:.:|||  :|:. :..|||::..:...|:.:::..|.
Human   593 DAHPCNPGSEVVENNFTLLNSFWFGM-GSLMQQG--SELMPKALSTRIIGGIWWFFTLIIISSYT 654

  Fly   434 AFIVGSLLSESARSIVNL--QALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYV------KKIC 490
            |.:...|..|...|.::.  .....:.:..|..........|..:.......::.      ..:.
Human   655 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALV 719

  Fly   491 KSGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCDLQEV---MFNLPYDS 549
            |:.|       :|.:|          |:...|.||:|   ::......|:|.::   :.:..|..
Human   720 KNNE-------EGIQR----------ALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGI 767

  Fly   550 GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE-VDLEHFAPALFALA 613
            |:  |.|||:|:.:..|:|..:....|....:||. |...|...:..:|. :.::........||
Human   768 GT--PMGSPYRDKITIAILQLQEEDKLHIMKEKWW-RGSGCPEEENKEASALGIQKIGGIFIVLA 829

  Fly   614 LAMVASALV 622
            ..:|.|.||
Human   830 AGLVLSVLV 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/61 (15%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	21/73 (29%)
		Lig_chan	353..602	CDD:459656	54/278 (19%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	39/208 (19%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	86/395 (22%)