DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir84a and GRIK2

DIOPT Version :9

Sequence 1:NP_649720.2 Gene:Ir84a / 40891 FlyBaseID:FBgn0037501 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:468 Identity:101/468 - (21%)
Similarity:191/468 - (40%) Gaps:50/468 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 IEKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDP 255
            :||.|.|..:.|.....:.|........:..|.:||.:|:| |:|    .:.:...||.|...|.
Human   399 LEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTIL-EEP----YVLFKKSDKPLYGNDR 458

  Fly   256 MQRKTYQLFQLVERMFNLSLAISLTD--KWGELLD-NGSWSGVMGQVTSREADFAVCPIRFVLDR 317
            .:.....|.:.:..:...:..|.|.:  |:|...| ||.|:|::.::...:||.||.|:.....|
Human   459 FEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVR 523

  Fly   318 QPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERM- 380
            :..:.:|....|..|..|:|.|..::.... |..|||..:|..:|....|.:.:|....|.... 
Human   524 EKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYE 588

  Fly   381 ----------LSNMENRFSFV---WFTMLETYLQQGPANEIF-RLFSTRLLISLSCIFSFMLMQF 431
                      ...:||.|:.:   ||. :...:|||  :|:. :..|||::..:...|:.:::..
Human   589 WYNPHPCNPDSDVVENNFTLLNSFWFG-VGALMQQG--SELMPKALSTRIVGGIWWFFTLIIISS 650

  Fly   432 YGAFIVGSLLSESARSIVNL--QALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGE 494
            |.|.:...|..|...|.::.  .....:.:..|..........|..:.......::.....:...
Human   651 YTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQS 715

  Fly   495 HNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCDLQEV---MFNLPYDSGSVM 553
            ..:.|.::|.:|::...:||          |:|   ::......|:|.::   :.:..|..|:  
Human   716 VLVKSNEEGIQRVLTSDYAF----------LMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGT-- 768

  Fly   554 PKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE-VDLEHFAPALFALALAMV 617
            |.|||:|:.:..|:|..:..|.|....:||. |...|...::.:|. :.:::.......||..:|
Human   769 PMGSPYRDKITIAILQLQEEGKLHMMKEKWW-RGNGCPEEESKEASALGVQNIGGIFIVLAAGLV 832

  Fly   618 ASALVFLLELFLH 630
            .|..|.:.| ||:
Human   833 LSVFVAVGE-FLY 844

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir84aNP_649720.2 nt_trans <54..>112 CDD:294020
Periplasmic_Binding_Protein_Type_2 222..583 CDD:304360 82/387 (21%)
Lig_chan 355..602 CDD:278489 50/270 (19%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 5/14 (36%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 84/390 (22%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 1/1 (100%)