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Protein Alignment Ir84a and GRIA4

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	615	Identity:	136/615 - (22%)
Similarity:	240/615 - (39%)	Gaps:	156/615 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 YGSPRT--AVLVLNSEHVLVRRQVFGVASEAGYFNNSLA-----WFILGSGRESLPVEQLIDQLL 150
            |.|..|  .|||:......:|||...: |..|...:.||     |   |.|   :.:|:.:.|:.
Human   296 YTSALTYDGVLVMAETFRSLRRQKIDI-SRRGNAGDCLANPAAPW---GQG---IDMERTLKQVR 353

  Fly   151 SGYRMGIDADITVALRGPDNASMLFYDVYRISRQAN-TPLIIEKKGLWTHSGGY----------- 203
            .   .|:..::.             :|.|  .|:.| |..:.|.|.......||
Human   354 I---QGLTGNVQ-------------FDHY--GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQ 400

  Fly   204 --QKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQL 266
              ...||  :|..|..|     |::.:|:: |.|       |:           |.:|.:::|:.
Human   401 DVPTLGN--DTAAIENR-----TVVVTTIM-ESP-------YV-----------MYKKNHEMFEG 439

  Fly   267 VERM----------------FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFV 314
            .::.                ....:||....|:|.. .|...|:|::|::...:|:.|:.|:...
Human   440 NDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTIT 504

  Fly   315 LDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLE 378
            |.|:..:.:|....:..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|..
Human   505 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 569

  Fly   379 RMLSNMENR-----------------FSFVWFTMLETYLQQG----PANEIFRLFSTRLLISLSC 422
            ....:.|..                 |:.:||: |..::|||    |     |..|.|::..:..
Human   570 PYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWW 628

  Fly   423 IFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVR----D 483
            .|:.:::..|.|.:...|..|  |.:..:::..|  ||...| |:|. .:.:.::.:..|    .
Human   629 FFTLIIISSYTANLAAFLTVE--RMVSPIESAED--LAKQTE-IAYG-TLDSGSTKEFFRRSKIA 687

  Fly   484 VYVK--KICKSGEHNIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDL 538
            ||.|  ...:|.|.::.  :..:|..|:  .:|:|||          |||..|:|    .:.||.
Human   688 VYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAF----------LLESTMNEYIEQRKPCDT 742

  Fly   539 QEVMFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTS 596
            .:|..||  ||   |...||||..|..:..|:|.....|:|.....||...:.:|    |..|..
Human   743 MKVGGNL--DSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDK 805

  Fly   597 QAEVDLEHFAPALFALALAMVASALVFLLE 626
            .:.:.|.:.|...:.|...:..:.||.|:|
Human   806 TSALSLSNVAGVFYILVGGLGLAMLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.