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Protein Alignment Ir84a and GRIA3

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	604	Identity:	146/604 - (24%)
Similarity:	246/604 - (40%)	Gaps:	135/604 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 YGSPRT--AVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM 155
            |.|..|  |:||:......:|||...| |..|...:.||       ..::|..|
Human   305 YTSALTHDAILVIAEAFRYLRRQRVDV-SRRGSAGDCLA-------NPAVPWSQ----------- 350

  Fly   156 GIDADITVALRGPDNASM---LFYDVYRISRQANTPLII--------EKKGLWTHSGGYQKFGNF 209
            ||  ||..||:......|   :.:|.|  .|:.|..:.:        .|.|.|..   |::|..|
Human   351 GI--DIERALKMVQVQGMTGNIQFDTY--GRRTNYTIDVYEMKVSGSRKAGYWNE---YERFVPF 408

  Fly   210 KNTWVIR-RRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQR-------KTYQLFQL 266
            .:..:.. ..:..|.|::.:|:| |.|       |:...|..:||:..:|       ..|::.:.
Human   409 SDQQISNDSASSENRTIVVTTIL-ESP-------YVMYKKNHEQLEGNERYEGYCVDLAYEIAKH 465

  Fly   267 VERMFNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQ 330
            |...:.||:...  .|:|.. .:...|:|::|::....||.||.|:...|.|:..:.:|....:.
Human   466 VRIKYKLSIVGD--GKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 528

  Fly   331 NIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERMLSNMENR------- 387
            .|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|......::|:.
Human   529 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593

  Fly   388 ------------FSFVWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFI 436
                        |:.:||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:
Human   594 QSPPDPPNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANL 652

  Fly   437 VGSLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVR----DVYVK--KICKSGEH 495
            ...|..|  |.:..:::..|  ||...| |:|. .:.:.::.:..|    .||.|  ...||.|.
Human   653 AAFLTVE--RMVSPIESAED--LAKQTE-IAYG-TLDSGSTKEFFRRSKIAVYEKMWSYMKSAEP 711

  Fly   496 NIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS--- 549
            ::.  :...|..|:  .:|:|||          |||..|:|    .:.||..:|..||  ||
Human   712 SVFTKTTADGVARVRKSKGKFAF----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGY 764

  Fly   550 GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC------SLFKTSQAEVDLEHFAPA 608
            |...||||..|..:..|:|.....|||.....||...:.:|      |..|||  .:.|.:.|..
Human   765 GVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTS--ALSLSNVAGV 827

  Fly   609 LF----ALALAMVASALVF 623
            .:    .|.|||:.:.:.|
Human   828 FYILVGGLGLAMMVALIEF 846

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.