DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir84a and GRIA2

DIOPT Version :9

Sequence 1:NP_649720.2 Gene:Ir84a / 40891 FlyBaseID:FBgn0037501 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens


Alignment Length:663 Identity:139/663 - (20%)
Similarity:253/663 - (38%) Gaps:147/663 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 HVLVVRGDDADGD-WKIECHQKLLANYRVQFYRPEMSANF-------EDLMFYGSPRT------- 98
            |.::......||| .||:.....::.:::..|...:.:.|       |:..:.|:..|       
Human   234 HYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSA 298

  Fly    99 ----AVLVLNSEHVLVRRQVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQL----LS 151
                ||.|:......:|:|...::  ..||  ..|.::.|   |.|.|   :|:.:.|:    ||
Human   299 LTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW---GQGVE---IERALKQVQVEGLS 357

  Fly   152 GYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTH-----------SGGYQK 205
            |           .::...|...:.|.:..:..:.|.|   .|.|.|:.           ..|...
Human   358 G-----------NIKFDQNGKRINYTINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDT 408

  Fly   206 FGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM 270
            .|            ..|.|::.:|:| |.|       |:...|..:.|:..:|.......|...:
Human   409 SG------------LENKTVVVTTIL-ESP-------YVMMKKNHEMLEGNERYEGYCVDLAAEI 453

  Fly   271 -----FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHT 329
                 |...|.|....|:|.. .|...|:|::|::...:||.|:.|:...|.|:..:.:|....:
Human   454 AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518

  Fly   330 QNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRL--------------ER 379
            ..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|.              |.
Human   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583

  Fly   380 MLSNMENRFSF---VWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIV 437
            ..|...|.|..   :||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:.
Human   584 QSSESTNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLA 642

  Fly   438 GSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM 498
            ..|..|  |.:..:::..|    :.:|.|..:.......|..:...:...::.  ..:|.|.::.
Human   643 AFLTVE--RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT--YMRSAEPSVF 703

  Fly   499 --SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSV 552
              :..:|..|:  .:|::|:          |||..|:|    .:.||..:|..||  ||   |..
Human   704 VRTTAEGVARVRKSKGKYAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIA 756

  Fly   553 MPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTSQAEVDLEHFAPALFALA 613
            .||||..|..:..|:|.....|:|.....||...:.:|    |..|...:.:.|.:.|...:.|.
Human   757 TPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 821

  Fly   614 LAMVASALVFLLE 626
            ..:..:.||.|:|
Human   822 GGLGLAMLVALIE 834

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir84aNP_649720.2 nt_trans <54..>112 CDD:294020 13/76 (17%)
Periplasmic_Binding_Protein_Type_2 222..583 CDD:304360 90/403 (22%)
Lig_chan 355..602 CDD:278489 62/286 (22%)
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 35/183 (19%)
PBP2_iGluR_AMPA 413..794 CDD:270433 92/410 (22%)
Glutamate binding 499..501 1/1 (100%)