Protein Alignment Ir84a and GRIA1

DIOPT Version :9

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 153/704 - (21%)
• Similarity: 271/704 - (38%)
• Gaps: 170/704 - (24%)

  Fly     1 MIKLQVKVISWPLIILTAFLRVLQIE-------SINTNFLELAAFEDFLRSEHLSHVLVVRGDDA 58
            :|||:...|.:..|:  |.|..:.|:       ..|....:|..:.|.:.::.:.
Human   226 IIKLEKNGIGYHYIL--ANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQ---------- 278

  Fly    59 DGDWKIECHQKLLANYRVQFYRPEMSANFEDLMFYGSPRT--AVLVLNSEHVLVRRQVFGVA--S 119
              .||   :.....:.||.:.||:          |.|..|  .|.|:......:|||...::  .
Human   279 --QWK---NSDARDHTRVDWKRPK----------YTSALTYDGVKVMAEAFQSLRRQRIDISRRG 328

  Fly   120 EAG--YFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM-GIDADITVALRGPDNASMLFYDVYRI 181
            .||  ..|.::.|   |.|   :.:::.:.|:    |. |:..::....:|
Human   329 NAGDCLANPAVPW---GQG---IDIQRALQQV----RFEGLTGNVQFNEKG-------------- 369

  Fly   182 SRQANTPL-IIEKK-------GLWTHSGGY-------QKFGNFKNTWVIRRRNFLNVTLIGSTVL 231
             |:.|..| :||.|       |.|.....:       |..|:  |:.|..|      |.|.:|:|
Human   370 -RRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGD--NSSVQNR------TYIVTTIL 425

  Fly   232 TEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM-----FNLSLAISLTDKWGEL-LDNG 290
             |.|       |:...|...|.:...|......:|...:     ::..|.|....|:|.. .|..
Human   426 -EDP-------YVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTK 482

  Fly   291 SWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSN 354
            :|:|::|::....||.||.|:...|.|:..:.:|....:..|..:.:.|::|..... |.:||:.
Human   483 AWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAY 547

  Fly   355 QVWWCVLALVTGSTILLL--------------FHVRLERMLSNMENRFSF---VWFTMLETYLQQ 402
            ::|.|::....|.:::|.              |....::..|:..|.|..   :||: |..::||
Human   548 EIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFS-LGAFMQQ 611

  Fly   403 G----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYD----SNL 459
            |    |     |..|.|::..:...|:.:::..|.|.:...|..|  |.:..:::..|    :.:
Human   612 GCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE--RMVSPIESAEDLAKQTEI 669

  Fly   460 AIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM--SLQQGAERI--IQGRFAFHTAIDR 520
            |.|..........|..:...:...::.  ..||.|.::.  :.::|..|:  .:|::|:
Human   670 AYGTLEAGSTKEFFRRSKIAVFEKMWT--YMKSAEPSVFVRTTEEGMIRVRKSKGKYAY------ 726

  Fly   521 MYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQY 578
                |||..|:|    .:.||..:|..||  ||   |...||||..|..:..|:|.....|||..
Human   727 ----LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDK 785

  Fly   579 NDKKWMVRRPDC------SLFKTSQAEVDLEHFAPALFALALAMVASALVFLLE 626
            ...||...:.:|      |..|||  .:.|.:.|...:.|...:..:.||.|:|
Human   786 LKNKWWYDKGECGSGGGDSKDKTS--ALSLSNVAGVFYILIGGLGLAMLVALIE 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	11/59 (19%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	91/403 (23%)
		Lig_chan	355..602	CDD:278489	65/288 (23%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	43/224 (19%)
		ANF_receptor	47..382	CDD:279440	40/207 (19%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	94/416 (23%)
		Lig_chan	548..827	CDD:278489	68/302 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940