DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and glr-5

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	657	Identity:	145/657 - (22%)
Similarity:	248/657 - (37%)	Gaps:	150/657 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 HQKLLANYRVQ--FYRPEMSA-NFEDLMFYGSPRTAVLVLNSEHVLVRRQVF---GVASEAGYFN 125
            |.:.::.|.|.  |......| ||.....:.:.:.|:...||.::.:...||   .|.:.|..||
Worm   264 HARFISPYPVDSTFLTENRDAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFDAVYAFANVFN 328

  Fly   126 NSLAWFILG---------SGRESLPVE---QLIDQLLSGYRMGIDADITVALRG---PDNASMLF 175
            ...:...:.         |.|.|...:   .|||.::.....|:..|:. .|.|   ..|.||..
Worm   329 ELSSHMQMNDVPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLR-RLNGHPLKSNFSMRI 392

  Fly   176 YDVYRISRQANTPLIIEKKGLW-------THSGGYQKFGNFKNTWVI-RRRNFLNVTLIGSTVLT 232
            ..:....|       ::..|.|       .:..|..|....:|..|. ..:....||.|     .
Worm   393 QLLGYSGR-------LDDIGFWEPATNVHVNMSGDSKAQLQRNVQVSDELKPHFRVTTI-----M 445

  Fly   233 EKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLT-------------DKWG 284
            |:|       |:...|...:||...:  ::.| .::.:..||..:..|             ||:|
Worm   446 ERP-------YVMLKKNHYELDANSK--FEGF-CIDLLAELSKDLGFTYTIHAVKDGKYGNDKYG 500

  Fly   285 ELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHP--RRSHIKNI 347
                ||||.|:||::...||:.||.|:.....|...|.::....:..|..|::.|  ::..:.:
Worm   501 ----NGSWDGMMGEILRGEAEMAVAPLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLFS- 560

  Fly   348 FFEPLSNQVWWCVLALVTGSTILLLFHVRLERMLSN--------------------------MEN 386
            |..|||.|:|..:...:...|:.:.|...:.....|                          |.|
Worm   561 FLNPLSWQIWTAIATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMSN 625

  Fly   387 RFSF---VWF---TMLETYLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSL-LSES 444
            .:||   ||:   |||:.....||     |..|||||.....:|..:::..|.|.:...| :|..
Worm   626 NYSFWNTVWYVLSTMLKGGCDFGP-----RAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRP 685

  Fly   445 ARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVRD----VYVK--KICKSGEHNIMSLQQG 503
            ...|.||..|.:..      .|||. .|...::.|..::    .:||  :..|..:..:.|..:|
Worm   686 YIPIKNLDDLANQT------TISYG-TIRGGSTMQFFQESRIAAHVKMWQYMKDKDVFVTSNGKG 743

  Fly   504 AERIIQGRFAFHTAIDRMYRLLLE---LQMDEAEFCDLQE---VMFNLPYDSGSVMPKGSPWREH 562
            .||          |:...|..|:|   |:.:..:.|:|.:   |:.:..|  |..:.|.|.|.:.
Worm   744 VER----------ALSMNYAYLMESTSLEYETQQNCNLTQIGGVLGSKGY--GIALAKKSEWTDR 796

  Fly   563 LAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLEHFAPALF-------ALALAMVASA 620
            ::..:|.:...|:::....||. |....:...|:.| |..:.||.:::       .|.:.:|.:|
Worm   797 ISRQILLYAKRGIIEMKKTKWW-RSKGAACASTASA-VKHDRFALSMYNVAGLFITLGVGIVLAA 859

  Fly   621 LVFLLEL 627
            :|.:.||
Worm   860 IVVIFEL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	10/47 (21%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	95/420 (23%)
		Lig_chan	355..602	CDD:278489	64/291 (22%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	32/161 (20%)
		ANF_receptor	38..377	CDD:279440	24/112 (21%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	97/425 (23%)
		Lig_chan	568..855	CDD:278489	67/312 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010