DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and glr-1

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_498887.2	Gene:	glr-1 / 176204	WormBaseID:	WBGene00001612	Length:	962	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	172/752 - (22%)
Similarity:	279/752 - (37%)	Gaps:	197/752 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LRVLQIESINTNFLELAA----FEDFL------RSEHLSHVLVVRGDDADGDWKIECH-----QK 69
            ||.....|:..:..:|.|    ||.:|      |:...:.:|            |:|.     :|
Worm   185 LRTRTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETNRIL------------IDCASPKRLKK 237

  Fly    70 LLANYRVQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILG 134
            ||.|.|        ||.|....::      .::.|.:.:...:::|    :.|..|.|....|..
Worm   238 LLINIR--------SAQFNQANYH------YVLANYDFLPYDQEMF----QNGNINISGFNIINK 284

  Fly   135 SGRE--SLPVEQLIDQLLSGYRMGIDADITVALRGPD---------------NASMLFYDVYRIS 182
            .|||  ||.........|.|   |.|..:..|: |.|               |.| ||:..:|..
Worm   285 DGREYWSLKKHLKTSSSLGG---GDDVSVEAAV-GHDAMLVTWHGFAKCLQANDS-LFHGTFRHR 344

  Fly   183 R------------------QANTPL-----------------IIEKKGLWTHSGGYQKFGNFKNT 212
            |                  ..|.|.                 |..|:|..|.:..:.:|||
Worm   345 RFFNRGFPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGN---- 405

  Fly   213 WVIRRRNF--LNVTLIGSTVLT---------EKPPGFGDMEYLADDKQLQQLDPMQRKTYQL--- 263
                |:||  ..|.|:.:|..|         .:..||.....:|...:..|.|....:...|
Worm   406 ----RKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKDNQVIVLTNL 466

  Fly   264 ---FQLVER----MFNLS------------------LA---------ISLTDKWGELLDNGSWSG 294
               |.:::|    |.||:                  ||         |.|..|.|....:|||.|
Worm   467 VAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKLGTKAGSKQADGSWDG 531

  Fly   295 VMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVW- 357
            ::|::.|..|...|..:....:|:..|.:|....|..|..:.:.|.:...... |.:|||.::|
Worm   532 MIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWM 596

  Fly   358 WCVLALVTGSTILLL------FHVRLER------MLSNMENRFSFVWFTMLETYLQQGPANEIFR 410
            :.:.|.:..|.::.|      :..|:|.      .:||..:.::.:||| |..::||| .:.:.|
Worm   597 YIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFT-LAAFMQQG-TDILPR 659

  Fly   411 LFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARS-IVNLQAL-YDSNLAIGMENISYNFPIF 473
            ..|.|:..|....|:.:::..|.|.:...|..|..:: |.:::.| ..|.:..|::........|
Worm   660 SISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFF 724

  Fly   474 TNTSNQLVRDVYVKKICKSGEHNIMSLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDEAEF- 535
            ..:|.|:.:.::.....:.....:.|..:|.||:  .:||:||          |||...:|.|.
Worm   725 KYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAF----------LLEATANEYENT 779

  Fly   536 ---CDLQEVMFNL-PYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKT- 595
               ||..:|..|| ....|...|.||.|::|:..|:|..:..|.|:..:.||...|..|....|
Worm   780 RKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDAGITV 844

  Fly   596 --SQAEVDLEHFAPALFALALAMVASALVFLLELFLH 630
              |.|.::|...|...:.|...||.|.|..|.| ||:
Worm   845 DGSSASLNLSKVAGIFYILMGGMVISMLAALGE-FLY 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	11/62 (18%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	98/429 (23%)
		Lig_chan	355..602	CDD:278489	66/271 (24%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	10..439	CDD:107375	61/296 (21%)
		ANF_receptor	44..417	CDD:279440	57/274 (21%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:304360	90/386 (23%)
		Lig_chan	593..867	CDD:278489	69/285 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010