DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir84a and glr-4

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	108/486 - (22%)
Similarity:	193/486 - (39%)	Gaps:	93/486 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTHSGGYQKFGNFKNTWVIRRR 218
            |..:..|:.....| :...::::.|.||:.|      ..|.|.|:...|:.....:.|.|..
Worm   342 RNQLTGDVQFKSNG-ERDDIMYHGVGRINSQ------FVKLGNWSEKRGWNFDSRYANRWEF--- 396

  Fly   219 NFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKT----YQLF--QLVERM-----FN 272
                          :..|...|:|.|.....:...:|...||    |:.|  .|:..|     ||
Worm   397 --------------DIDPDSEDLEGLHLRVVVYLEEPFVIKTGENQYEGFCIDLLNEMTQVLKFN 447

  Fly   273 LSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFR 337
            .::.......:|...::|.|:|::|.:...|||.::..:.....|...|.::.......|..|..
Worm   448 YTIIEVQDGTYGIEDESGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLA 512

  Fly   338 HPRRSHIKN---IFFEPLSNQVWWCVLALVTGSTILLLFHV----------RLERM-------LS 382
            .......|.   .|.||||..||  :..|::...:....|:          .|||:       :.
Worm   513 RTSEETDKGSLWTFLEPLSLTVW--ISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIK 575

  Fly   383 NMENRFSFV---WFTMLETYLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFY----GAFIVGSL 440
            |.:|:|:.:   |||| .:.:||| ::.|.|..:|||:..:..:|:.:::..|    .||:....
Worm   576 NQKNQFTVLNSFWFTM-GSLMQQG-SDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVER 638

  Fly   441 LS---ESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM--SL 500
            :|   ||.:.:.|.|     .:..|:.........|..:...:...::  .:.:|....:.  |.
Worm   639 MSTPIESTQDLANQQ-----KIRYGVLKSGSTMDFFRESKIPMYERMW--SVMESSSPGVFVNSS 696

  Fly   501 QQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPYDS---GSVMPKGSPWREH 562
            ::|..|:..|.:|:     .|...:||..::..  |:||.:...|  ||   |..:|||||.|:.
Worm   697 REGIARVKSGGYAY-----MMESSMLEYYLERD--CELQSIGGLL--DSKGYGIALPKGSPLRDI 752

  Fly   563 LAHALLHFRATGLLQ-YNDKKWMVRR--PDC 590
            |:..:|..:...:|: ..:|.|..||  |.|
Worm   753 LSRTVLQLQERTILEALKNKWWRDRREGPSC 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	90/407 (22%)
		Lig_chan	355..602	CDD:278489	64/271 (24%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	11/49 (22%)
		ANF_receptor	45..365	CDD:279440	3/23 (13%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	86/384 (22%)
		Lig_chan	533..810	CDD:278489	64/271 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010