Protein Alignment Ir84a and Grin3b

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 418
• Identity: 85/418 - (20%)
• Similarity: 164/418 - (39%)
• Gaps: 57/418 - (13%)

  Fly   266 LVERM-----FNLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSA 325
            |:||:     |:..|.|....|:|.|.| |.|:|::|.:.:..|..||........|...|.:::
  Rat   483 LLERLAEDLAFDFELYIVGDGKYGALRD-GRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTS 546

  Fly   326 VLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVWWCVL-ALVTGSTILLLFHVRLERMLS----NME 385
            ...:.::..:.|....:.....|..||...:|..|. ||...:..|.|:..|....|:    |..
  Rat   547 PFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRG 611

  Fly   386 NRFSF-----VWFTML--ETYLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSE 443
            ..||:     :.:.:|  .|...:.|     :..:.|.|::|..||..:::..|.|.:...::.:
  Rat   612 TVFSYSSALNLCYAILFGRTVSSKTP-----KCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGD 671

  Fly   444 SARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIMSLQQGAERII 508
              ::...|..::|..|....:...:. .::.:::...::..:.:.......|:..:...|...:.
  Rat   672 --KTFEELSGIHDPKLHHPSQGFRFG-TVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLT 733

  Fly   509 QGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPY---DSGSVMPKGSPWREHLAHALLHF 570
            ......:..|  |.:.||:.::.....|.|..|  ..|:   ..|..:|:.||...:|:..:..:
  Rat   734 SDPPKLNAFI--MDKSLLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRY 794

  Fly   571 RATGLLQYNDKKWMVRRPDCS--LFK-TSQAEVDLEHFAPALFALALAMVASAL-------VFL- 624
            :::|.:.....||....| |.  :|. |...::.:.||: .||.|....:.|||       ||.
  Rat   795 KSSGFIDLLHDKWYKMVP-CGKRVFAVTETLQMGVYHFS-GLFVLLCLGLGSALLTSLGEHVFYR 857

  Fly   625 -----------LELFLHWLPDFRRRLGT 641
                       |:.:||......|.|.|
  Rat   858 LVLPRIRRGNKLQYWLHTSQKIHRALNT 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	17/72 (24%)
		Lig_chan	353..602	CDD:459656	46/266 (17%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	64/337 (19%)
		Lig_chan	574..841	CDD:459656	51/280 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910		2/4 (50%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984