Protein Alignment Ir84a and Grin2b

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 748
• Identity: 136/748 - (18%)
• Similarity: 253/748 - (33%)
• Gaps: 204/748 - (27%)

  Fly    25 IESINTNFLELAAFEDF---LRSE--------HLSHVLVVRGDDADGDWKIECHQKLLANYRVQF 78
            |.||.|.:  ...::||   :||.        .|..||::.....|||.||:...|.|.:..:..
Mouse   168 IFSIVTTY--FPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILL 230

  Fly    79 YRPEMSANFEDLMFYGSPRTAVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFI---LGSGRESL 140
            |..:..|.:                          :|.||:..|.......|.:   :....:::
Mouse   231 YCTKEEATY--------------------------IFEVANSVGLTGYGYTWIVPSLVAGDTDTV 269

  Fly   141 PVEQLIDQLLSGY-----------RMGIDADITVALRG--------PDNASMLFYD----VYRIS 182
            |.|.....:...|           |.|| |.||.|...        |:..|..:..    :|: |
Mouse   270 PSEFPTGLISVSYDEWDYGLPARVRDGI-AIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQ-S 332

  Fly   183 RQANTPLI---IEKKGLWTHSGGYQ-----------------KFGNFKN--------TW------ 213
            ...|..||   .|.:.|.....|||                 :.|.:|:        .|
Mouse   333 NMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPE 397

  Fly   214 --------------------VIRRRNFLNVTLIGSTV----------LTEKPPGF------GDME 242
                                ::...:.|:.|.:.:||          .|::.||:      |
Mouse   398 TEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKG--- 459

  Fly   243 YLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFA 307
            :..|  .|:::....:.||.|:            :....|.|:.: ||:|:|::|:|..:.|..|
Mouse   460 FCID--ILKKISKSVKFTYDLY------------LVTNGKHGKKI-NGTWNGMIGEVVMKRAYMA 509

  Fly   308 VCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVW--WCVLALVTGSTIL 370
            |..:....:|...|.:|.......|..:......:...:.|.||.|..||  ..|:.|:..:..:
Mouse   510 VGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAV 574

  Fly   371 LLFH----VRLERMLSN----------MENRFSFVWFTMLETYLQ-QGPANEIFRLFSTRLLISL 420
            .:|.    |...|.|::          :......:|..:....:. |.|...     ::::::|:
Mouse   575 FVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-----TSKIMVSV 634

  Fly   421 SCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIGME-NISYNFPIFTNTSNQL-VRD 483
            ...|:.:.:..|.|.:...::.|  ..:..:..|.|.......: :..:.|....|.|.:. :|:
Mouse   635 WAFFAVIFLASYTANLAAFMIQE--EYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN 697

  Fly   484 VYVKKICKSGEHN-------IMSLQQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEV 541
            .|.:.....|:.|       ::||:.|.    ...|.:..|:       |.......|.|.|..:
Mouse   698 NYAEMHAYMGKFNQRGVDDALLSLKTGK----LDAFIYDAAV-------LNYMAGRDEGCKLVTI 751

  Fly   542 MFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLE 603
            .....:.|   |..:.|.|.|:..:..|:|.....|.::..:..|:.........:...:::|::
Mouse   752 GSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDID 816

  Fly   604 HFAPALFALALAMVASALVFLLELFLHWLPDFR 636
            :.|...:.|..||..|.:.|:.|...:|  .||
Mouse   817 NMAGVFYMLGAAMALSLITFICEHLFYW--QFR 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/57 (16%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	19/72 (26%)
		Lig_chan	353..602	CDD:459656	44/277 (16%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	49/249 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	75/435 (17%)
		NMDAR2_C	840..1482	CDD:463148	3/10 (30%)