Protein Alignment Ir84a and Grik1

DIOPT Version :10

• Sequence 1: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 616
• Identity: 144/616 - (23%)
• Similarity: 236/616 - (38%)
• Gaps: 117/616 - (18%)

  Fly    81 PEMSA-----NFEDLMFYGSPRTAVL--VLNSEHVLVRRQVFGVASEAGYFNNSLA--------- 129
            |.:|:     :.|.|.....|.|.:|  |:.:|..|:...|:.||. |.:..:.|.
Mouse   288 PHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMYDAVYMVAI-ASHRASQLTVSSLQCHRH 351

  Fly   130 --WFILGSGRESLPVEQLIDQL--------LSGYRMGIDADITVALR--GPDNA----SMLFYDV 178
              | .||....:|..|...|.|        ..|.|...|.|| ::|:  |.:.|    |...|.|
Mouse   352 KPW-RLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDI-ISLKEEGTEKASGEVSKHLYKV 414

  Fly   179 YRISRQANTPLIIEKKGLWTHSGGYQKFGNFKNTWVIRRRN----FLNVTLIGSTVLTEKPPGFG 239
            ::            |.|:|..:.|.......::    |..|    ..|.|||.:|:| |:|
Mouse   415 WK------------KIGIWNSNSGLNMTDGNRD----RSNNITDSLANRTLIVTTIL-EEP---- 458

  Fly   240 DMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLT--DKWGELLDNGSWSGVMGQVTSR 302
            .:.|...||.|...|..:.....|.:.:..:......:.|.  .|:|...|.|.|:|::.::...
Mouse   459 YVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDH 523

  Fly   303 EADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTG 366
            .||.||.|:.....|:..:.:|....|..|..|:|.|..::.... |..|||..:|..||....|
Mouse   524 RADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLG 588

  Fly   367 STILLLFHVRLERM-----------LSNMENRFSFV---WFTMLETYLQQGPANEIF-RLFSTRL 416
            .:.:|....|....           ...:||.|:.:   ||. :...:|||  :|:. :..|||:
Mouse   589 VSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFG-VGALMQQG--SELMPKALSTRI 650

  Fly   417 LISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDS--NLAIGMENISYNFPIFTNTSNQ 479
            :..:...|:.:::..|.|.:...|..|...|.:      ||  :|| ....|.|.
Mouse   651 VGGIWWFFTLIIISSYTANLAAFLTVERMESPI------DSADDLA-KQTKIEYG---------- 698

  Fly   480 LVRD----VYVKKICKSGEHNI---MSLQQGAERIIQGRFAFHTAIDRMYRLLLE---LQMDEAE 534
            .|||    .:.||...|....:   ||.:|.:..:..........:...|.||:|   ::.....
Mouse   699 AVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQR 763

  Fly   535 FCDLQEV---MFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTS 596
            .|:|.::   :.:..|..|:  |.|||:|:.:..|:|..:..|.|....:||. |...|....:.
Mouse   764 NCNLTQIGGLIDSKGYGVGT--PIGSPYRDKITIAILQLQEEGKLHMMKEKWW-RGNGCPEEDSK 825

  Fly   597 QAE-VDLEHFAPALFALALAMVASALVFLLE 626
            :|. :.:|:.......||..:|.|..|.:.|
Mouse   826 EASALGVENIGGIFIVLAAGLVLSVFVAIGE 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	10/37 (27%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	22/73 (30%)
		Lig_chan	353..602	CDD:459656	62/279 (22%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	37/157 (24%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	95/396 (24%)