DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and Grid2

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	669	Identity:	132/669 - (19%)
Similarity:	265/669 - (39%)	Gaps:	105/669 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ESINTNFLELAAFEDFLRSEHLSHVLVVRGDDADGDWKIECHQKL--LANYRVQFYRPEMSANFE 88
            |.:.||   |.||:        .|.:::..:..|.|.:....:.:  |...|..|..|:   |..
Mouse   245 EVVETN---LVAFD--------CHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQ---NIS 295

  Fly    89 DLMFYGSPR-------------------------TAVLVLNSEH-VLVRRQVFGVASEAGYFNNS 127
            ...|.|:.|                         |.:|:.|:.| .|..|:...:||.:....||
Mouse   296 QRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNS 360

  Fly   128 LAWFILGSGRESLPVEQLIDQLLSGYRMGIDADITVALRG--PDNASMLFYDVYRISRQANTPLI 190
            ..|   ..||      .:::.:..|...|:..|:.....|  |:    :.:::...:........
Mouse   361 KPW---QGGR------SMLETIKKGGVNGLTGDLEFGENGGNPN----VHFEILGTNYGEELGRG 412

  Fly   191 IEKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQ--QL 253
            :.|.|.|....|..  |:..:..:  ..|...|.|...||| |:|........|...|:.|  .:
Mouse   413 VRKLGCWNPVTGLN--GSLTDKKL--ENNMRGVVLRVVTVL-EEPFVMVSENVLGKPKKYQGFSI 472

  Fly   254 DPMQRKTYQLFQLVERMFNLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQ 318
            |.:...:..|      .||..:.::...|:|...::|:|:|::|::..:.||..:..:....||:
Mouse   473 DVLDALSNYL------GFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRE 531

  Fly   319 PYVQYSAVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVWWCV--LALVTGSTILLLFHVRLERM- 380
            ..|.::......::..|.|...::........|....:|.|:  ..|:.|..:.||..:...|:
Mouse   532 NVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQ 596

  Fly   381 LSNMENR--FSFVWFTMLETYLQQGPANEI-FRLFSTRLLISLSCIFSFMLMQFY----GAFIVG 438
            :.:|.:.  ::.:|| :..:::|||  .|: :...:||:::....:|:.:::..|    .||:..
Mouse   597 MGSMTSTTLYNSMWF-VYGSFVQQG--GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTI 658

  Fly   439 SLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICK------SGEHNI 497
            :.:..|.:|:.:|....|......:::..|.. :.....|...||....::.:      ..|:|:
Mouse   659 TRIESSIQSLQDLSKQTDIPYGTVLDSAVYQH-VRMKGLNPFERDSMYSQMWRMINRSNGSENNV 722

  Fly   498 MSLQQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQEVMFNLPYDSGSVMPKGSPWREH 562
            :..|.|.:::..|.:||  ..|......:.:...:..|..:...:.:..|  |..:..|||:|:.
Mouse   723 LESQAGIQKVKYGNYAF--VWDAAVLEYVAINDPDCSFYTVGNTVADRGY--GIALQHGSPYRDV 783

  Fly   563 LAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAE-----VDLEHFAPALFALALAMVASALV 622
            .:..:|..:.:|.:.....||..:...|.|:.:..|:     :|::..|.....||..:|.|.|:
Mouse   784 FSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLI 848

  Fly   623 FLLELFLHWLPDFRRRLGT 641
            .:||.   |   :.||.|:
Mouse   849 AVLET---W---WSRRKGS 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	15/85 (18%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	73/378 (19%)
		Lig_chan	355..602	CDD:278489	50/267 (19%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		22/113 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	40/212 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	75/380 (20%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840