DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and Grid1

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	507	Identity:	109/507 - (21%)
Similarity:	199/507 - (39%)	Gaps:	89/507 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 KKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFG-DMEYLA---DDKQLQ-- 251
            |||..|...|..:|....:      ..::...::|:|.    ...|| ||..||   .:|.|.
Mouse   370 KKGHITGLTGVMEFREDSS------NPYVQFEILGTTY----SETFGKDMRKLATWDSEKGLNGS 424

  Fly   252 -QLDPM----QRKTYQLFQLVERMFNL-------------SLAISLTD----------------- 281
             |..||    |..|.::..::|..|.:             ..:|.:.|
Mouse   425 LQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPD 489

  Fly   282 -KWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIK 345
             ::|..|.|.||:|::|::.|:.||.|:..|....:|:..|.:|......::..|.:.|......
Mouse   490 GRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISI 554

  Fly   346 NIFFEPLSNQVWWCVLAL--VTGSTILLLFHVRLERMLSNMENR-------FSFVWFTMLETYLQ 401
            ...|.|....||.|:.|.  |.|..|.:|..::..|..|..:.|       .|.:|. :...::|
Mouse   555 FSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWI-VYGAFVQ 618

  Fly   402 QGPANEIFRLFSTRLLISLSCIFSFMLMQFY----GAFIVGSLLSESARSIVNLQALYDSNLAIG 462
            ||..:.: ...:.|:::....:|:.::...|    .||:..|.:....|:..:|....:.:....
Mouse   619 QGGESSV-NSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTV 682

  Fly   463 MENISYNFPIFTNTSNQLVRDVYV----KKICKSG--EHNIMSLQQGAERIIQGRFAF--HTAID 519
            .::..|.: .....:|.|.:|...    :.|.|:|  ::.:.:..:|..:..:|.:||  ..|:.
Mouse   683 RDSAVYEY-FRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVV 746

  Fly   520 RMYRLLLELQMDEAEFCDLQEVMFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWM 584
            . |..|.:   |:.....:...:.:..|  |..:..|||:|:..:..:|..:.||.|....:||.
Mouse   747 E-YAALTD---DDCSVTVIGNSISSKGY--GIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWW 805

  Fly   585 VRRPDCSLFKTSQAEVD-----LEHFAPALFALALAMVASALVFLLELFLHW 631
            .....|.|...|..:.:     |..||.....||:.::.:.||..|||:  |
Mouse   806 PHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELW--W 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	87/423 (21%)
		Lig_chan	355..602	CDD:278489	54/272 (20%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		19/75 (25%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	16/62 (26%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	75/378 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840