DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and Gria2

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	680	Identity:	141/680 - (20%)
Similarity:	261/680 - (38%)	Gaps:	147/680 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HVLVVRGDDADGD-WKIECHQKLLANYRVQFYRPEMSANF-------EDLMFYGS-----PRTAV 100
            |.::......||| .||:.....::.:::..|...:.:.|       |:..:.|:     ..|:.
Mouse   234 HYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSA 298

  Fly   101 LVLNSEHVL------VRRQVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQL----LS 151
            |..::..|:      :|:|...::  ..||  ..|.::.|   |.|.|   :|:.:.|:    ||
Mouse   299 LTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW---GQGVE---IERALKQVQVEGLS 357

  Fly   152 GYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTH-----------SGGYQK 205
            |           .::...|...:.|.:..:..:.|.|   .|.|.|:.           ..|...
Mouse   358 G-----------NIKFDQNGKRINYTINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDT 408

  Fly   206 FGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM 270
            .|            ..|.|::.:|:| |.|       |:...|..:.|:..:|.......|...:
Mouse   409 SG------------LENKTVVVTTIL-ESP-------YVMMKKNHEMLEGNERYEGYCVDLAAEI 453

  Fly   271 -----FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHT 329
                 |...|.|....|:|.. .|...|:|::|::...:||.|:.|:...|.|:..:.:|....:
Mouse   454 AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518

  Fly   330 QNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRL--------------ER 379
            ..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|.              |.
Mouse   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583

  Fly   380 MLSNMENRFSF---VWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIV 437
            ..|...|.|..   :||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:.
Mouse   584 QSSESTNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLA 642

  Fly   438 GSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM 498
            ..|..|  |.:..:::..|    :.:|.|..:.......|..:...:...::.  ..:|.|.::.
Mouse   643 AFLTVE--RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT--YMRSAEPSVF 703

  Fly   499 --SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSV 552
              :..:|..|:  .:|::|:          |||..|:|    .:.||..:|..||  ||   |..
Mouse   704 VRTTAEGVARVRKSKGKYAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIA 756

  Fly   553 MPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTSQAEVDLEHFAPALFALA 613
            .||||..|..:..|:|.....|:|.....||...:.:|    |..|...:.:.|.:.|...:.|.
Mouse   757 TPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 821

  Fly   614 LAMVASALVFLLELFLHWLPDFRRRLGTMS 643
            ..:..:.||.|:|.......:.:|...|:|
Mouse   822 GGLGLAMLVALIEFCYKSRAEAKRMKMTLS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	12/76 (16%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	90/403 (22%)
		Lig_chan	355..602	CDD:278489	62/286 (22%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	34/183 (19%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	92/410 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940