DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and grin3bb

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	525	Identity:	106/525 - (20%)
Similarity:	194/525 - (36%)	Gaps:	108/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 LIIEKKGLWTHSGGYQK----FGNFKNTWVIRRRNF-LNVTLIGSTVLTEKPPGF-------GDM 241
            |.:|::|||..|...|:    .|.....|   |..| ::.:.:....|.|.|..|       |:.
Zfish   419 LNVEEQGLWQGSSPRQRTEGQMGREGRRW---RAGFPVSGSRLRVVTLVEHPFVFTREVDEDGNC 480

  Fly   242 ---EYLAD--DKQLQQLDPMQRKTYQ-----------------LFQLVERM-----FNLSLAISL 279
               :|..|  ....:.||.:..:..|                 ...|:|::     |...|.|..
Zfish   481 PAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVG 545

  Fly   280 TDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHI 344
            ..|:| .:..|.|:|::|.:.|..||.||........|...:.:::...:.::..|.|....:..
Zfish   546 DGKYG-AVKGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTAAP 609

  Fly   345 KNIFFEPLSNQVWWCV-LALVTGSTILLLFHVRLE-RMLSNMENR---FSF-----VWFTML--E 397
            ...|..||...:|..: :||...:..|.|:..:.. .|..:..||   ||:     :.:.:|  .
Zfish   610 IGAFMWPLHWSMWMGIFVALHITALFLTLYEWKSPFGMTPHGRNRVKVFSYSSALNLCYAILFGR 674

  Fly   398 TYLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDSNLAIG 462
            |...:.|     :.::.|.|::|..||..:::..|.|.:...::.|  ::...:..::|:.|...
Zfish   675 TVSSKTP-----KCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGE--KTFEEVSGIHDAKLHHP 732

  Fly   463 MENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIMSLQQGAERIIQGRFAFHTAIDR------- 520
            .:...:      .|..:...:.|:||.... .|..|.           :|...|..|.
Zfish   733 SQGFRF------GTVRESSAEDYMKKSFPE-MHEYMR-----------KFNEPTTPDGVATLKTD 779

  Fly   521 --------MYRLLLELQMDEAEFCDLQEVMFNLPY---DSGSVMPKGSPWREHLAHALLHFRATG 574
                    |.:.||:.::.....|.|..|  ..|:   ..|..:|:.||...:::..:..:::.|
Zfish   780 PPQLDAFIMDKALLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDG 842

  Fly   575 LLQYNDKKWMVRRPDCS--LFK-TSQAEVDLEHFAPALFALALAMVASALVFLL---ELFLHWLP 633
            .:.....||....| |.  :|. |...::.:.||: .||.|....|..||:.|.   ..:...||
Zfish   843 YMDMLHDKWYKVVP-CGKRVFAVTETLQMGIRHFS-GLFVLLCVGVTGALLTLAGEHAFYRLVLP 905

  Fly   634 DFRRR 638
            ..||:
Zfish   906 HIRRK 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	76/424 (18%)
		Lig_chan	355..602	CDD:278489	50/279 (18%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	4/8 (50%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	77/422 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840