DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir84a and LOC100149482

DIOPT Version :9

Sequence 1:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	670	Identity:	137/670 - (20%)
Similarity:	233/670 - (34%)	Gaps:	170/670 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 GSPRTAVLVLNSEHVLVR---------RQVFGVASEAGYFNNSLAWFILGSGRESLPVEQLIDQL 149
            |..||..|:..:| ..||         .|||..|..||....|..||.:|.....|.:..|..:|
Zfish   241 GGVRTQRLLKENE-AQVRLLYCSQEEAEQVFLAAWAAGQAGASHIWFAVGPALSELGLTGLPKRL 304

  Fly   150 LS----GYR----------MGIDADITVALR-------GPDNASMLFYDVYRISR---------- 183
            .:    |:|          :.|.....||||       ||...:....|..|..|
Zfish   305 FAVRPQGWRDEPRRRIARGVSILTHGAVALRKDYGATGGPHFVTNCQTDGNRTQRIRGRMRYFSN 369

  Fly   184 ---------------QANTPLIIEKKGLWTHSGGYQKFGNFKN--------TW------------ 213
                           .||..|.:..   :|...|::..|.::|        .|
Zfish   370 ITLGGRDYSFSNEGYLANPFLDVIS---YTPGSGWEDVGWWENGVLRLRYPAWSRYGPFLQPPDD 431

  Fly   214 -------VIRRRNFLNV--------TLIGSTVLTEKPPGFGDM-EYLADDKQLQQ---LDPMQRK 259
                   .:..|.|:.|        |.|..:|...:|.....: |.:|..||..:   :|.::|
Zfish   432 AQHLRVVTLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQEGVAPVKQCCKGFCIDILKR- 495

  Fly   260 TYQLFQLVERMFNLSLAISLTDKWGELLDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYS 324
               |.::|.  |...|.:....|.|:.:| |.|:|::|:|..:.||.|:..:....:|...|.:|
Zfish   496 ---LARIVG--FTYDLYLVTNGKHGKKID-GVWNGMVGEVVYKRADMAIGSLTINEERSEVVDFS 554

  Fly   325 AVLHTQNIHFLFRHPRRSHIKNIFFEPLSNQVW--WCVLALVTGSTILLLFH----VRLERMLSN 383
            .......|..:......:...:.|.||.|..||  ..|:.|...:..:.:|.    |...|.|.:
Zfish   555 VPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVGYNRSLQS 619

  Fly   384 ME----NRFSF---VWFTMLETYLQQGPANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIVGSLL 441
            .:    ::|:.   :|......:....|. |..:..::::::.:...|:.:.:..|.|.:...::
Zfish   620 GKKAGGSKFTIGKSIWLLWALVFNNSVPV-ENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMI 683

  Fly   442 SESARSIVNLQALYDSN----------LAIGM-------ENISYNFPIFTNTSNQLVRDVY---V 486
            .|  ..|..:..|.|..          |..|.       :||..|:|           |::   |
Zfish   684 QE--EYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRSNYP-----------DMHQYMV 735

  Fly   487 KKICKSGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLLLELQMDEAEFCDLQ-----EVMFNLP 546
            |...||.|..|..|:.|.    ...|.:..|:       |.....:.|.|.:.     :|.....
Zfish   736 KYNQKSVEDAISHLKTGK----LDAFIYDAAV-------LNYMARKDEGCKVMTIGSGKVFATTG 789

  Fly   547 YDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDCSLFKTSQAEVDLEHFAPALFA 611
            |  |..:.|.|.|:..|..|||.......::..::.|:.........:...:::|:::.|...:.
Zfish   790 Y--GIALIKNSRWKRPLDLALLQLVGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYM 852

  Fly   612 LALAMVASALVFLLELFLHW 631
            |.:||..|.|||..|..::|
Zfish   853 LLVAMGLSLLVFAWEHLVYW 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	7/26 (27%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	83/410 (20%)
		Lig_chan	355..602	CDD:278489	50/284 (18%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	40/183 (22%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	86/431 (20%)
		HisJ	<487..>570	CDD:223904	21/89 (24%)
		Lig_chan	585..857	CDD:278489	53/298 (18%)
		NMDAR2_C	868..>900	CDD:287527	1/5 (20%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930