DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and TLR5

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_003259.2 Gene:TLR5 / 7100 HGNCID:11851 Length:858 Species:Homo sapiens


Alignment Length:851 Identity:180/851 - (21%)
Similarity:316/851 - (37%) Gaps:222/851 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   259 IPNKNFTALICTHKNC-------------------NFIRGINGLECPKLCQCLYIIDDLELNIDC 304
            ||:.:|...|..::.|                   |:||.:.....|.|.|    :..|||....
Human    21 IPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQ----LQLLELGSQY 81

  Fly   305 SNL-----GLLQIPPLPIPSYGGVKLNFSN----NSLSQLPTMTL-----------PGY----KL 345
            :.|     ....:|.|.|...|..|:.|.:    ..|..|..:.|           .||    |.
Human    82 TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKA 146

  Fly   346 VKRLDVSRNRLTNLSINHLPAKLDYL---DVSFNEIINMGNDVIKYL--RTVPIFKQTGNQW--T 403
            :.|||:|:|::.:|.::....||:.|   |.|.|:|..:....::.|  :|:..|....|..  .
Human   147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSR 211

  Fly   404 IHCDDKPLLNFFRHLKLIIR-------------------MKSAEMKPMFLHSLTELPKGF--LK- 446
            :..|....:|.||::.|.|.                   .||.....:..|.:.....||  :| 
Human   212 VSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKD 276

  Fly   447 -----FLG-----------KHFIWLGVRKQEYYLINEEQLLQSMHRKLN-----------NLNTI 484
                 |.|           .|.....:..:.:..:.:.::|...:.|:|           ||..:
Human   277 PDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVL 341

  Fly   485 MSIYKYMEWLHR-------KLIFVN-REYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFV 541
            ...|..:..|:.       |:.::: ::..:..|:........|.:....||:.:..|    .|:
Human   342 NLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI----HFI 402

  Fly   542 YNFPDIVARNSRL--MGKQNMSSPMELHLSKNNISNITIAMLPKELRFLDLRFNNLVTLDDKVLS 604
            .:.|||....::|  :.|.|:::.: :|||:|.:.|:.|      |.|| ||..:|..|      
Human   403 PSIPDIFLSGNKLVTLPKINLTANL-IHLSENRLENLDI------LYFL-LRVPHLQIL------ 453

  Fly   605 YLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWP 669
            .|.:|.. :..||:....:..|...|.:..:...|.::.                     .|.|.
Human   454 ILNQNRF-SSCSGDQTPSENPSLEQLFLGENMLQLAWET---------------------ELCWD 496

  Fly   670 SFIVDCRGEGL--LQM------------PSLSSRVTY---VDLRNNNLTALS------------- 704
            .|      |||  ||:            |.:.|.:|.   :.|.:|.||.||             
Human   497 VF------EGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDI 555

  Fly   705 QKNRSSIENRS--LKLHLLD---NPWSCSCNDIEKINFMKSVSSSIV-DFTEIKC-----SNGEK 758
            .:|:....|..  :.|.:||   |.:.|.|.....||::...:.:|. ...:|.|     .:|..
Human   556 SRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVS 620

  Fly   759 LVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYEHGVCLSL--SAKRELDKD 821
            |.|::.......::...|..::.:|.|:....||:    .:|......|.|...  :|:|.:.||
Human   621 LFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLM----TILTVTKFRGFCFICYKTAQRLVFKD 681

  Fly   822 K---------RFDAFLAFTHKD-----EALLEEFVDRLERGRPRFQLCFYLRDWLAGESIPDCIG 872
            .         ::||:|.|:.||     .|||:. :|.....:.||.|||..||::.||:....|.
Human   682 HPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKH-LDTQYSDQNRFNLCFEERDFVPGENRIANIQ 745

  Fly   873 QSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFDSLDSE-LRTYM 936
            .:|.:||:|:.|::.:|:...|....|..|......|....||:|:..::..:..:..: :|.::
Human   746 DAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFV 810

  Fly   937 AFNTYL 942
            ....||
Human   811 QKQQYL 816

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 6/38 (16%)
leucine-rich repeat 346..367 CDD:275378 6/20 (30%)
leucine-rich repeat 563..583 CDD:275378 6/19 (32%)
leucine-rich repeat 585..610 CDD:275378 8/24 (33%)
leucine-rich repeat 611..622 CDD:275378 2/10 (20%)
TIR 823..960 CDD:214587 36/126 (29%)
TLR5NP_003259.2 LRR 1. /evidence=ECO:0000269|PubMed:22173220 45..68 3/22 (14%)
leucine-rich repeat 48..83 CDD:275378 9/38 (24%)
LRR 2. /evidence=ECO:0000269|PubMed:22173220 71..93 5/25 (20%)
PLN00113 90..>581 CDD:331614 107/536 (20%)
LRR 3. /evidence=ECO:0000269|PubMed:22173220 95..117 6/21 (29%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
LRR 4. /evidence=ECO:0000269|PubMed:22173220 120..143 4/22 (18%)
leucine-rich repeat 121..146 CDD:275380 4/24 (17%)
LRR 5. /evidence=ECO:0000269|PubMed:22173220 146..166 6/19 (32%)
leucine-rich repeat 147..171 CDD:275380 8/23 (35%)
LRR 6. /evidence=ECO:0000269|PubMed:22173220 171..192 5/20 (25%)
leucine-rich repeat 172..205 CDD:275380 8/32 (25%)
LRR 7. /evidence=ECO:0000269|PubMed:22173220 197..211 3/13 (23%)
LRR 8. /evidence=ECO:0000269|PubMed:22173220 214..229 4/14 (29%)