DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MstProx and TLR9

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_059138.1 Gene:TLR9 / 54106 HGNCID:15633 Length:1032 Species:Homo sapiens


Alignment Length:1121 Identity:217/1121 - (19%)
Similarity:373/1121 - (33%) Gaps:419/1121 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 HLEVNWKIP---------------DPNIFIISPISKENRLKLNELI-------------VSDTSY 86
            ||.:.|..|               :|:.|:..|..:|..|..|.::             :|.|:.
Human    91 HLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNI 155

  Fly    87 ---------PIRAVDYL------------RQ---------LGVETVTRFENQINSFKVIERDVHY 121
                     .:.|:.:|            ||         ||:..:|....:.|:..|:.|    
Human   156 LMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPR---- 216

  Fly   122 INGPKSLKIIIQSNLYLNEIIEYINKTTDNVNEIII----------------------------- 157
             |.|.||:.::   |..|.|::...:...|:..:.:                             
Human   217 -NLPSSLEYLL---LSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHP 277

  Fly   158 ----------------------NA--YKTVENQQIALD---NLI---------FNGKSHLRSLTF 186
                                  ||  ::.:.|.:: ||   |.:         |.|.:.||.|. 
Human   278 DTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRV-LDLSENFLYKCITKTKAFQGLTQLRKLN- 340

  Fly   187 IGFQIE------NLSTKP-FAQFINLKRMVLTNCTVRNL--TFLRTLQK--SLEHLELDID--NE 238
            :.|..:      :||..| |...:.||.:.:.....|:|  |.||.|.:  .|:.|.|.::  |:
Human   341 LSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQ 405

  Fly   239 VDLKYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGL-------------------- 283
            ..|..|..|..|:::.:.:                 |.|.|.:.|                    
Human   406 AQLGIFRAFPGLRYVDLSD-----------------NRISGASELTATMGEADGGEKVWLQPGDL 453

  Fly   284 -----ECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVK-LNFSNNSLSQ-------L 335
                 :.|...........|...:|.|...|:.:.|........:: |..|:|.:||       |
Human   454 APAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFL 518

  Fly   336 PTMTLPGYKLVKRLDVSRNRLT---NLSINHLPAKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQ 397
            |   |.|.::   ||:|.|:|.   ..|...|| :|:.||:|:|.                  :.
Human   519 P---LTGLQV---LDLSHNKLDLYHEHSFTELP-RLEALDLSYNS------------------QP 558

  Fly   398 TGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQEY 462
            .|.|...|     ..:|..||:.:..:..|...   :||..                        
Human   559 FGMQGVGH-----NFSFVAHLRTLRHLSLAHNN---IHSQV------------------------ 591

  Fly   463 YLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSR 527
                .:||..:..|.|:.....:.   :| |         .|.||                    
Human   592 ----SQQLCSTSLRALDFSGNALG---HM-W---------AEGDL-------------------- 619

  Fly   528 DSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISNI---TIAMLPKELRFLD 589
                        :::.|             |.:|..:.|.||:|.:..:   |:..|||.|:.|.
Human   620 ------------YLHFF-------------QGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLR 659

  Fly   590 LRFNNLVTLDDKVLSYLKK--------NSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLK 646
            ||.|.|.......|.:|.|        |.:|...:|:                    |.....|:
Human   660 LRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGS--------------------LPAGTRLR 704

  Fly   647 RCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLT--ALSQKNRS 709
            |.::|   |..:           ||:.          |...|:..  :||..||:  ||...:.|
Human   705 RLDVS---CNSI-----------SFVA----------PGFFSKAK--ELRELNLSANALKTVDHS 743

  Fly   710 SIENRSLKLHLLD---NPWSCSCNDIEKINFMKSVSSSIVDF-TEIKCSNGEKLVSIN---QHI- 766
            .....:..|.:||   ||..|:|. ...::|:..|.:::... :.:||.:..:|..::   |.: 
Human   744 WFGPLASALQILDVSANPLHCACG-AAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLR 807

  Fly   767 VCPSDLFYYLALAISLVATIIALNFLIWFRQPVL-------VWFYEHGVCLSLS--AKRELDKDK 822
            :|..:...:...|:||:|..:.|..      |:|       :|:..| :||:..  ..|:..:|:
Human   808 LCLDEALSWDCFALSLLAVALGLGV------PMLHHLCGWDLWYCFH-LCLAWLPWRGRQSGRDE 865

  Fly   823 ---RFDAFLAFTHKDEALLE----EFVDRLE--RGRPRFQLCFYLRDWLAGESIPDCIGQSIKDS 878
               .:|||:.|.....|:.:    |...:||  |||...:||...||||.|:::.:.:..|:..|
Human   866 DALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGS 930

  Fly   879 RRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLI-VVLYPNVKNFDSLDSELRTYMAFNTYL 942
            |:.:.::......|...|..|.||......||...:: |:|.|:.:.  |....||..:...:.|
Human   931 RKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRR--SRYVRLRQRLCRQSVL 993

  Fly   943 ERSHP-----NFWNKL 953
            ...|.     :||.:|
Human   994 LWPHQPSGQRSFWAQL 1009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 9/26 (35%)
leucine-rich repeat 346..367 CDD:275378 8/23 (35%)
leucine-rich repeat 563..583 CDD:275378 6/22 (27%)
leucine-rich repeat 585..610 CDD:275378 9/32 (28%)
leucine-rich repeat 611..622 CDD:275378 2/10 (20%)
TIR 823..960 CDD:214587 39/143 (27%)
TLR9NP_059138.1 leucine-rich repeat 43..64 CDD:275380
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 47..51
LRR 1 62..85
LRR_8 64..135 CDD:290566 10/43 (23%)
leucine-rich repeat 65..88 CDD:275380
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 72..77
LRR 2 87..110 4/18 (22%)
leucine-rich repeat 89..124 CDD:275380 6/32 (19%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 95..109 2/13 (15%)
LRR 3 122..147 4/24 (17%)
LRR_8 123..177 CDD:290566 8/53 (15%)
leucine-rich repeat 125..144 CDD:275380 3/18 (17%)
leucine-rich repeat 145..168 CDD:275380 2/22 (9%)
LRR 4 150..166 2/15 (13%)
LRR 5 167..190 4/22 (18%)
leucine-rich repeat 169..200 CDD:275380 5/30 (17%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 179..181 0/1 (0%)
LRR 6 198..221 6/27 (22%)
LRR_8 200..254 CDD:290566 12/61 (20%)
leucine-rich repeat 201..221 CDD:275380 6/24 (25%)
leucine-rich repeat 222..245 CDD:275380 5/25 (20%)
LRR 7 223..242 3/21 (14%)
LRR 8 243..268 0/24 (0%)
leucine-rich repeat 246..285 CDD:275380 0/38 (0%)
LRR 9 283..306 2/22 (9%)
LRR_8 284..344 CDD:290566 11/61 (18%)
leucine-rich repeat 286..307 CDD:275380 2/20 (10%)
LRR 10 308..332 5/24 (21%)
leucine-rich repeat 310..335 CDD:275380 5/25 (20%)
LRR 11 333..356 5/23 (22%)
leucine-rich repeat 336..365 CDD:275380 8/29 (28%)
LRR 12 363..386 6/22 (27%)
leucine-rich repeat 366..392 CDD:275380 8/25 (32%)
LRR 13 390..413 6/22 (27%)
leucine-rich repeat 393..416 CDD:275380 7/22 (32%)
LRR 14 415..440 5/41 (12%)
leucine-rich repeat 417..472 CDD:275380 6/71 (8%)
LRR 15 470..494 5/23 (22%)
LRR_RI 476..739 CDD:238064 82/427 (19%)
leucine-rich repeat 476..497 CDD:275380 4/20 (20%)
LRR_8 496..555 CDD:290566 21/65 (32%)
LRR 16 496..519 5/22 (23%)
leucine-rich repeat 498..522 CDD:275380 8/26 (31%)
LRR 17 520..543 8/25 (32%)
leucine-rich repeat 523..546 CDD:275380 8/26 (31%)
LRR 18 545..572 10/50 (20%)
leucine-rich repeat 547..599 CDD:275380 16/105 (15%)
LRR 19 574..598 6/54 (11%)
LRR_8 598..665 CDD:290566 23/124 (19%)
leucine-rich repeat 600..629 CDD:275380 9/86 (10%)
LRR 20 600..622 7/66 (11%)
LRR 21 627..650 6/22 (27%)
leucine-rich repeat 630..654 CDD:275380 7/23 (30%)
LRR 22 652..675 9/22 (41%)
leucine-rich repeat 655..678 CDD:275380 8/22 (36%)
LRR 23 676..699 6/42 (14%)
leucine-rich repeat 679..702 CDD:275380 4/42 (10%)
LRR_8 701..762 CDD:290566 19/86 (22%)
LRR 24 701..723 7/45 (16%)
leucine-rich repeat 703..726 CDD:275380 8/48 (17%)
LRR 25 724..747 7/24 (29%)
leucine-rich repeat 727..748 CDD:275380 7/20 (35%)
LRR 26 749..772 7/23 (30%)
leucine-rich repeat 752..770 CDD:275380 7/18 (39%)
TIR_2 870..1009 CDD:304906 38/140 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.