Protein Alignment MstProx and Tlr5

DIOPT Version :9

• Sequence 1: NP_649719.2
• Gene: MstProx / 40890
• FlyBaseID: FBgn0015770
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: XP_017177186.1
• Gene: Tlr5 / 53791
• MGIID: 1858171
• Length: 873
• Species: Mus musculus
• Alignment Length: 995
• Identity: 193/995 - (19%)
• Similarity: 351/995 - (35%)
• Gaps: 309/995 - (31%)

  Fly    62 IFIISPISKENR------------------------LKLNEL-IVSDTSYPIRAVDYLRQLGVET 101
            :.:|||.|.:.|                        |..|.: :|..||:|:.....|.:||.:.
Mouse    32 VLVISPCSSDGRIAFFRGCNLTQIPWILNTTTERLLLSFNYISMVVATSFPLLERLQLLELGTQY 96

  Fly   102 VT------RFENQIN---------SFKVIERDVHYINGPKSLKIIIQS--------------NLY 137
            ..      .|.|..|         ..:|:.||. :...|..|::.:.|              |||
Mouse    97 ANLTIGPGAFRNLPNLRILDLGQSQIEVLNRDA-FQGLPHLLELRLFSCGLSSAVLSDGYFRNLY 160

  Fly   138 ----------------LNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTF 186
                            |:.....:|..:| ||......:...|::...|..         ::|:|
Mouse   161 SLARLDLSGNQIHSLRLHSSFRELNSLSD-VNFAFNQIFTICEDELEPLQG---------KTLSF 215

  Fly   187 IGFQIENLSTKPFAQFINLKRMVLTNCTVRNLTF----LRTLQKSLEHLELDIDNEVDLKYFTNF 247
            .|.::    ||.|:      |:.:...|.|| .|    |.||..|.....:||..        ||
Mouse   216 FGLKL----TKLFS------RVSVGWETCRN-PFRGVRLETLDLSENGWTVDITR--------NF 261

  Fly   248 SSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQI 312
            |        |.|.....::||..|.......|...:..|.......:.....|.:|.|:..:..:
Mouse   262 S--------NIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSL 318

  Fly   313 PPLPIPSYGGVK----LNFSNNSLSQLPTMTLPGYKLVKRLDVSRN---RLTNLSINHLPAKLDY 370
            .|   ..:|.:|    ||.:.|.::::......|...::.|::|.|   .|.|.:...|| ::.|
Mouse   319 NP---RLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLP-RVAY 379

  Fly   371 LDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPL--LNFFRHLKLIIRMKSAEMKPMF 433
            :|:..|.|..:.:...:.|:|:.         |:...|..|  :.|...:::::...:..:....
Mouse   380 VDLQRNHIGIIQDQTFRLLKTLQ---------TLDLRDNALKAIGFIPSIQMVLLGGNKLVHLPH 435

  Fly   434 LH---SLTELPKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLH 495
            :|   :..||.:..|:.|...:..|.|.:.::.::|:           |.|::..:.:...|
Mouse   436 IHFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQ-----------NRLSSCKAAHTPSE--- 486

  Fly   496 RKLIFVNREYDLFYIRQMAAPCPHKCECCY------SRDSLILKIDCRNKFVYNFP-----DIVA 549
                  |...:..::.:.......:...|:      ||..::.   ..|.::...|     |:||
Mouse   487 ------NPSLEQLFLTENMLQLAWETGLCWDVFQGLSRLQILY---LSNNYLNFLPPGIFNDLVA 542

  Fly   550 RNSRLMGKQNMSSPMELHLSKNNISNITIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTK 614
            ...             |.||.|.::.::...||..|..||:..|.|.:.|..:.|.|:...|
Mouse   543 LRM-------------LSLSANKLTVLSPGSLPANLEILDISRNQLFSPDPALFSSLRVLDI--- 591

  Fly   615 LSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEG 679
             :.|.:.|:|:..:.:|.|.     :.:|||..   ||.|     |.|:    :|
Mouse   592 -THNEFVCNCELSTFISWLN-----QTNVTLFG---SPAD-----VYCM----YP---------- 628

  Fly   680 LLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLDNPWSCSCNDIEKINFMKSVSSS 744
                                         :|:...||        ::.|..|.::...|:|:..|
Mouse   629 -----------------------------NSLLGGSL--------YNISTEDCDEEEAMRSLKFS 656

  Fly   745 IVDFTEIKCSNGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYEHGVC 809
            :                   .|:|.      :.|.:.||.|::.:.|              .|:|
Mouse   657 L-------------------FILCT------VTLTLFLVITLVVIKF--------------RGIC 682

  Fly   810 LSL--SAKRELDKDK---------RFDAFLAFTHKD-----EALLEEFVDRLERGRPRFQLCFYL 858
            ...  :.::.:.|||         |:||:..|:.||     .|||:. :|.....|.|.:|||..
Mouse   683 FLCYKTIQKLVFKDKVWSLEPGAYRYDAYFCFSSKDFEWAQNALLKH-LDAHYSSRNRLRLCFEE 746

  Fly   859 RDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVK 923
            ||::.||:....|..::..||:.:.|::.:|:...|....||.|...:..|....||||:..::.
Mouse   747 RDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRSLSDLKSILIVVVVGSLS 811

  Fly   924 NFDSLDSE-LRTYMAFNTYL 942
            .:..:..| :|.::....||
Mouse   812 QYQLMRHETIRGFLQKQQYL 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	4/19 (21%)
		leucine-rich repeat	346..367	CDD:275378	7/23 (30%)
		leucine-rich repeat	563..583	CDD:275378	5/19 (26%)
		leucine-rich repeat	585..610	CDD:275378	8/24 (33%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	37/126 (29%)
Tlr5	XP_017177186.1	leucine-rich repeat	63..93	CDD:275380	7/29 (24%)
		LRR_8	<101..146	CDD:338972	9/45 (20%)
		leucine-rich repeat	112..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..161	CDD:275380	4/24 (17%)
		leucine-rich repeat	162..186	CDD:275380	1/23 (4%)
		leucine-rich repeat	187..242	CDD:275380	16/75 (21%)
		leucine-rich repeat	243..304	CDD:275380	16/76 (21%)
		leucine-rich repeat	305..328	CDD:275380	5/25 (20%)
		LRR_8	308..363	CDD:338972	12/57 (21%)
		leucine-rich repeat	329..352	CDD:275380	4/22 (18%)
		LRR_8	352..411	CDD:338972	15/68 (22%)
		leucine-rich repeat	353..376	CDD:275380	7/23 (30%)
		leucine-rich repeat	377..400	CDD:275380	5/22 (23%)
		PRK15370	<397..>597	CDD:185268	42/248 (17%)
		leucine-rich repeat	401..429	CDD:275380	4/36 (11%)
		leucine-rich repeat	430..464	CDD:275380	7/33 (21%)
		leucine-rich repeat	465..489	CDD:275380	5/43 (12%)
		leucine-rich repeat	490..518	CDD:275380	1/27 (4%)
		leucine-rich repeat	519..542	CDD:275380	3/25 (12%)
		leucine-rich repeat	543..561	CDD:275380	4/30 (13%)
		leucine-rich repeat	565..585	CDD:275380	6/19 (32%)
		PCC	569..>647	CDD:188093	26/145 (18%)
		TIR	708..858	CDD:366714	36/125 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010