DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and TLR8

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1098 Identity:237/1098 - (21%)
Similarity:417/1098 - (37%) Gaps:338/1098 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 KLNELIVSDTS------YPIRAVDYLRQLGVET--VTRFENQINSFKVIER----------DVHY 121
            |.|:.::::.|      .|.....|:.:|.:..  :|...|:  ||:.::.          :|.:
Human    58 KQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNE--SFQGLQNLTKINLNHNPNVQH 120

  Fly   122 INGPKSLKIIIQSN-------LYLNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKS 179
            .||...    ||||       .:||         ..|:.|:::.     :||   |..:......
Human   121 QNGNPG----IQSNGLNITDGAFLN---------LKNLRELLLE-----DNQ---LPQIPSGLPE 164

  Fly   180 HLRSLTFIGFQIENLSTKPFAQFINLKRMVLT-NC-----------------TVRNLTFLRTLQK 226
            .|..|:.|...|.|::.:..::.||||.:.|. ||                 |:.||..|.....
Human   165 SLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFN 229

  Fly   227 SLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQC 291
            ||.|:...:.:.: .|.|.:.:.:|      ||..::|..||    |...: .::| .||:    
Human   230 SLSHVPPKLPSSL-RKLFLSNTQIK------YISEEDFKGLI----NLTLL-DLSG-NCPR---- 277

  Fly   292 LYIIDDLELNIDCSNLGLLQIPPLP-IPSYGGVKLN---FSNNSLSQLPTMTLPGYKL------- 345
                        |.|      .|.| :|..||..:|   |:..:|:||..:.|....|       
Human   278 ------------CFN------APFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAW 324

  Fly   346 ------VKRLDVSRNRL-----TNLSINHLPAKLDYLDVSFNEI-------INMGNDVIKYLRTV 392
                  :|.||:..|.|     :...:..|| :|:.||:|||.|       ||:..:..|.|...
Human   325 FKNMPHLKVLDLEFNYLVGEIASGAFLTMLP-RLEILDLSFNYIKGSYPQHINISRNFSKLLSLR 388

  Fly   393 PIFKQTGNQWTIHCDDKPLLNFFRHLK--LIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWL 455
            .:                      ||:  :...::..:.:|     |.:||......||.:||  
Human   389 AL----------------------HLRGYVFQELREDDFQP-----LMQLPNLSTINLGINFI-- 424

  Fly   456 GVRKQEYYLINEEQLLQSMHRKLNNLNTIM-----------SIYKYMEWLHRKLIFVNREYDLFY 509
              ::.::.|......|:.::...|.::.::           |..:::    ||....:.|:|   
Human   425 --KQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHI----RKRRSTDFEFD--- 480

  Fly   510 IRQMAAPCPH-----------KCECCYSRDSLILKIDC-----RNKFVYNFPDIVARNSRLMGKQ 558
                    ||           |.:|.....:|.|.::.     .|:| .|.|||...|.......
Human   481 --------PHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQF-ENLPDIACLNLSANSNA 536

  Fly   559 NMSSPME---------LHLSKN-----NISNIT------------------IAMLPKELRF---- 587
            .:.|..|         |.|:.|     |.|.:|                  ||.:...|.|    
Human   537 QVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNF 601

  Fly   588 -----LDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNP----WNCDCKSRSVLSILRDHEPL-EYD 642
                 |:|..||:.||.|| .:...|:.::...|||.    ||.|  ....:||.:..:.| ..|
Human   602 TNLKVLNLSHNNIYTLTDK-YNLESKSLVELVFSGNRLDILWNDD--DNRYISIFKGLKNLTRLD 663

  Fly   643 VTLKRCNISPTDCPDVCVCCL------DNL----TWPSF-------IVDCRGEGLL--------- 681
            ::|.|....|.:........|      ||:    .|...       ::|.||..||         
Human   664 LSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDF 728

  Fly   682 ---------------QMPS--LS--SRVTYVDLRNNNLTALSQKNRSSIENR-SLKLHLLD---N 723
                           .:||  ||  |.:.::||.:|.|..:   |:|::|.: :.||.:|:   |
Human   729 TSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTI---NKSALETKTTTKLSMLELHGN 790

  Fly   724 PWSCSCNDIEKINFM-KSVSSSIVDFTEIKCSN-----GEKLVSINQHIVCPSD----LFYYLAL 778
            |:.|:|:..:...:| :.::..|....::.|::     |:.:||: :...|.||    :.::...
Human   791 PFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL-ELTTCVSDVTAVILFFFTF 854

  Fly   779 AISLVATIIALNFLIWFRQPVLVWFYEHGVCLS-LSAKRELDKDKRF-DAFLAFTHKDEA----L 837
            .|:.:..:.||...:::..   |||. :.|||: :...|.|...:.| ||::::..||.:    :
Human   855 FITTMVMLAALAHHLFYWD---VWFI-YNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWV 915

  Fly   838 LEEFVDRLERGRPR-FQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRL 901
            :.|....||..|.: ..||...|||..|.:|.|.:.|||..|::.:.::|:.:..|...:..|.|
Human   916 INELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYL 980

  Fly   902 ALHATSRDRCKRLI-VVLYPNVKNFDSLDSELRTYMAFNTYLE-----RSHPNFWNKL 953
            ||.....:....:| ::|.|.:::...|  .||..:..::.|:     ::...||..|
Human   981 ALQRLMDENMDVIIFILLEPVLQHSQYL--RLRQRICKSSILQWPDNPKAEGLFWQTL 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 6/22 (27%)
leucine-rich repeat 346..367 CDD:275378 7/25 (28%)
leucine-rich repeat 563..583 CDD:275378 9/51 (18%)
leucine-rich repeat 585..610 CDD:275378 11/33 (33%)
leucine-rich repeat 611..622 CDD:275378 4/14 (29%)
TIR 823..960 CDD:214587 37/143 (26%)
TLR8NP_057694.2 LRR_8 83..155 CDD:290566 18/94 (19%)
leucine-rich repeat 83..106 CDD:275380 5/24 (21%)
leucine-rich repeat 107..144 CDD:275380 9/49 (18%)
leucine-rich repeat 145..165 CDD:275380 4/27 (15%)
leucine-rich repeat 166..189 CDD:275380 5/22 (23%)
leucine-rich repeat 190..220 CDD:275380 6/29 (21%)
leucine-rich repeat 221..241 CDD:275380 5/19 (26%)
LRR_8 240..317 CDD:290566 25/111 (23%)
leucine-rich repeat 242..265 CDD:275380 8/33 (24%)
leucine-rich repeat 266..306 CDD:275380 13/63 (21%)
LRR_8 305..367 CDD:290566 17/62 (27%)
leucine-rich repeat 307..330 CDD:275380 3/22 (14%)
leucine-rich repeat 331..356 CDD:275380 7/25 (28%)
leucine-rich repeat 387..413 CDD:275380 5/52 (10%)
LRR_8 412..>449 CDD:290566 8/40 (20%)
leucine-rich repeat 414..437 CDD:275380 5/26 (19%)
LRR_8 502..560 CDD:290566 14/58 (24%)
LRR_RI <504..719 CDD:238064 50/218 (23%)
leucine-rich repeat 504..524 CDD:275380 5/20 (25%)
leucine-rich repeat 525..549 CDD:275380 4/23 (17%)
LRR_8 548..614 CDD:290566 13/65 (20%)
leucine-rich repeat 550..573 CDD:275380 6/22 (27%)
leucine-rich repeat 574..603 CDD:275380 4/28 (14%)
leucine-rich repeat 604..658 CDD:275380 17/56 (30%)
LRR_8 657..718 CDD:290566 12/60 (20%)
leucine-rich repeat 659..683 CDD:275380 5/23 (22%)
leucine-rich repeat 684..707 CDD:275380 4/22 (18%)
LRR_8 706..766 CDD:290566 13/59 (22%)
leucine-rich repeat 708..730 CDD:275380 5/21 (24%)
leucine-rich repeat 732..755 CDD:275380 4/22 (18%)
leucine-rich repeat 756..775 CDD:275380 6/21 (29%)
LRRCT 790..835 CDD:214507 9/44 (20%)
TIR 898..1040 CDD:214587 36/141 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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