DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and TLR7

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:1115 Identity:240/1115 - (21%)
Similarity:406/1115 - (36%) Gaps:375/1115 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 KVIERDVHYINGPKSLKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKTVENQQI-ALDNLI-- 174
            |.:..|| .::.||:..|:..::.:|.||...|...|.|:. :.||....:..... .||:|:  
Human    32 KTLPCDV-TLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLT-LTINHIPDISPASFHRLDHLVEI 94

  Fly   175 ----------------------------FNGKSHLRSLTFIGFQIENL--STKPFAQFINLKRMV 209
                                        |:|.::|:||...|.|:..:  ...|..|.::|:...
Human    95 DFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANN 159

  Fly   210 LTNCTVRNLTFLRTLQKSLEHLELD----------IDNEVDLKYFTNFSSLKFMKVRNYIPNKNF 264
            :.:....|||.|    .::|.|.|.          :...::...|.|.:.||.:.::    :.|.
Human   160 IFSIRKENLTEL----ANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLK----DNNV 216

  Fly   265 TALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNI---DCSNLGLLQIPPL----------P 316
            ||:...              .|.....||:.:::...|   |.:||..|||..|          |
Human   217 TAVPTV--------------LPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAP 267

  Fly   317 IPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHLPA-------KLDYLDVS 374
            .|.     ....|||..|:|.........:|.|     ||.:.|:.|:|.       ||..||:|
Human   268 FPC-----APCKNNSPLQIPVNAFDALTELKVL-----RLHSNSLQHVPPRWFKNINKLQELDLS 322

  Fly   375 FNEIINMGNDVIKYLRTVPIFKQTGNQWT----IHCDDKPLLNFFRHLK----LIIR------MK 425
            .|.:.....|. |:|..:|...|....:.    ::.....|...|..||    |.||      :|
Human   323 QNFLAKEIGDA-KFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELK 386

  Fly   426 SAEMKPMFLHSL-----TELPKGFLKF----LGKHF-----IWLGVRK----------------- 459
            |..:.|  ||:|     .:|...|:|.    :.|.|     |.|.|.|                 
Human   387 SFNLSP--LHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNAR 449

  Fly   460 --QEYYLINEEQLLQSMH-----------RKLNNLNTIMSI----YKYMEWLH------------ 495
              .|.|   |.|:|:.:|           |..|...:.||:    |||.:.|.            
Human   450 TSVESY---EPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSS 511

  Fly   496 ---------------------------------RKLIFVNREYDLFYIRQMAAPCPHKCECC--- 524
                                             |.|.|.|...||  :...|....||.|..   
Human   512 DFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDL--LHSTAFEELHKLEVLDIS 574

  Fly   525 ----------------YSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQ--------------- 558
                            ::::..:|:     |.:.|..||.:..||.|..:               
Human   575 SNSHYFQSEGITHMLNFTKNLKVLQ-----KLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVL 634

  Fly   559 -------------NMSSPMELHLSKNNISNITIAM---LPKELRFLDLRFN-------------- 593
                         |:....||.:|||::|.:...:   :|..|:.|.|..|              
Human   635 WREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLK 699

  Fly   594 NLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLS-ILRDHEPLEYDVTLKRCNISPTDCPD 657
            ||.|||   ||:.:..::..:||    ||   |||:.: ||::::                    
Human   700 NLETLD---LSHNQLTTVPERLS----NC---SRSLKNLILKNNQ-------------------- 734

  Fly   658 VCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIEN--RSLKLHL 720
                 :.:|| ..|:.|            :.::.|:||.:|.:..: ||. |..||  .:||:.|
Human   735 -----IRSLT-KYFLQD------------AFQLRYLDLSSNKIQMI-QKT-SFPENVLNNLKMLL 779

  Fly   721 L-DNPWSCSCNDIEKINFMKSVSSSIVDF-TEIKC-----SNGEKLVSINQHIVCPSDL----FY 774
            | .|.:.|:|:.:..:.::.....:|... |::.|     ..|:.::|::.: .|..||    .:
Human   780 LHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLY-TCELDLTNLILF 843

  Fly   775 YLALAISLVATII--ALNFLIWFRQPVLVWFYEHGVCLSLSA-KRELDKDKRFDAFLAFTHKDEA 836
            .|::::||...::  |.:...|.     ||:..|.....:.. :|.:..|..:|||:.:..||.|
Human   844 SLSISVSLFLMVMMTASHLYFWD-----VWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPA 903

  Fly   837 LLE----EFVDRLERGRPR-FQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGR 896
            :.|    |.|.:||..|.: |.||...||||.|:.:.:.:.|||:.|::.:.:||:.:..:...:
Human   904 VTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFK 968

  Fly   897 LEFRLALHATSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYLE-----RSHPNFW------ 950
            :.|.|: |....|....:|::::.......|...:||..:..::.||     ::||.||      
Human   969 IAFYLS-HQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNA 1032

  Fly   951 ----NKLIYS 956
                |.:.||
Human  1033 LATDNHVAYS 1042

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 5/19 (26%)
leucine-rich repeat 346..367 CDD:275378 7/27 (26%)
leucine-rich repeat 563..583 CDD:275378 6/22 (27%)
leucine-rich repeat 585..610 CDD:275378 11/38 (29%)
leucine-rich repeat 611..622 CDD:275378 2/10 (20%)
TIR 823..960 CDD:214587 43/154 (28%)
TLR7NP_057646.1 leucine-rich repeat 598..651 CDD:275380 9/57 (16%)
LRR 21 619..644 0/24 (0%)
leucine-rich repeat 621..643 CDD:275380 0/21 (0%)
LRR 22 649..672 6/22 (27%)
leucine-rich repeat 652..676 CDD:275380 7/23 (30%)
LRR 23 674..697 5/22 (23%)
leucine-rich repeat 677..700 CDD:275380 4/22 (18%)
LRR 24 698..721 9/29 (31%)
leucine-rich repeat 701..724 CDD:275380 11/32 (34%)
LRR 25 723..745 7/47 (15%)
leucine-rich repeat 725..748 CDD:275380 6/60 (10%)
LRR 26 746..769 7/24 (29%)
leucine-rich repeat 749..767 CDD:275380 6/19 (32%)
PCC 753..>837 CDD:188093 21/86 (24%)
LRR 27 772..795 7/22 (32%)
TIR 890..>993 CDD:214587 31/103 (30%)
LRR 1 43..64 6/20 (30%)
leucine-rich repeat 48..69 CDD:275380 6/20 (30%)
LRR 2 65..87 4/22 (18%)
LRR_8 75..139 CDD:404697 10/63 (16%)
leucine-rich repeat 91..128 CDD:275380 3/36 (8%)
LRR 3 110..126 1/15 (7%)
LRR 4 127..149 5/21 (24%)
leucine-rich repeat 129..173 CDD:275380 12/47 (26%)
LRR 5 151..170 4/18 (22%)
LRR 6 171..195 4/27 (15%)
PLN00113 191..>711 CDD:215061 116/563 (21%)
LRR 7 203..226 6/40 (15%)
leucine-rich repeat 206..225 CDD:275380 5/36 (14%)
leucine-rich repeat 227..250 CDD:275380 6/22 (27%)
LRR 8 228..247 4/18 (22%)
LRR 9 248..275 7/31 (23%)
leucine-rich repeat 251..291 CDD:275380 11/44 (25%)
LRR 10 289..312 7/27 (26%)
leucine-rich repeat 292..315 CDD:275380 7/27 (26%)
LRR 11 314..337 8/23 (35%)
leucine-rich repeat 316..341 CDD:275380 8/25 (32%)
LRR 12 339..368 4/28 (14%)
leucine-rich repeat 342..371 CDD:275380 4/28 (14%)
LRR 13 369..392 7/22 (32%)
leucine-rich repeat 372..398 CDD:275380 9/27 (33%)
LRR 14 396..419 4/22 (18%)
leucine-rich repeat 399..422 CDD:275380 5/22 (23%)
LRR 15 421..443 4/21 (19%)
LRR <488..775 CDD:227223 63/343 (18%)
LRR 16 492..515 4/22 (18%)
leucine-rich repeat 496..518 CDD:275380 1/21 (5%)
LRR 17 516..540 0/23 (0%)
leucine-rich repeat 519..543 CDD:275380 0/23 (0%)
LRR 18 541..564 7/24 (29%)
leucine-rich repeat 544..567 CDD:275380 7/24 (29%)
LRR 19 566..588 3/21 (14%)
leucine-rich repeat 568..597 CDD:275380 1/28 (4%)
LRR 20 595..618 8/27 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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