DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and CD180

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_005573.2 Gene:CD180 / 4064 HGNCID:6726 Length:661 Species:Homo sapiens


Alignment Length:806 Identity:155/806 - (19%)
Similarity:275/806 - (34%) Gaps:259/806 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 GVETVTRFENQINSFKVIERDVHYINGPKSLKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKT 162
            |.:.:|.::..     .||::.:        |.....||.|:||.:.:..||:.: |...|...|
Human    17 GCKVITSWDQM-----CIEKEAN--------KTYNCENLGLSEIPDTLPNTTEFL-EFSFNFLPT 67

  Fly   163 VENQQIALDNLIFNGKSHLRSLTFIGF---QIENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTL 224
            :.|:..          |.|.:|||:..   ||..:....|.....|..:|||.   ..|.|:...
Human    68 IHNRTF----------SRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTG---NPLIFMAET 119

  Fly   225 Q----KSLEHLEL--------------DIDNEVDLKYFTN-FSSLKFMK---VRN---------- 257
            .    |||:||.|              :::|...|...:| .||:||.|   .||          
Human   120 SLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNA 184

  Fly   258 --YIPNKNFTAL-----ICTHKNCNFIRGI-------------------------NGLECPKLCQ 290
              ||..::..:|     :..:.|.|.::||                         |||: ....|
Human   185 IHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQ-NSTTQ 248

  Fly   291 CLYI--IDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSR 353
            .|::  .:|:: :.|.|:..|..:..:.:.|     ||...:..|.:.:.|...:..::.||::.
Human   249 SLWLGTFEDID-DEDISSAMLKGLCEMSVES-----LNLQEHRFSDISSTTFQCFTQLQELDLTA 307

  Fly   354 NRLTN---------------LSINHLPAKLDYLDVSFNEIINM---GNDVIKYLRT-VPIFKQTG 399
            ..|..               ||:||..........:|..:.::   ||  :|.|.. |...::.|
Human   308 THLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN--VKKLHLGVGCLEKLG 370

  Fly   400 NQWTI---HCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQE 461
            |..|:   |.|                :::::...:.|.:|:.|....|    .|...||::.|.
Human   371 NLQTLDLSHND----------------IEASDCCSLQLKNLSHLQTLNL----SHNEPLGLQSQA 415

  Fly   462 YYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYS 526
            :....:.:||.....:| ::|...|.::.:.:|.    .:|..|                  |: 
Human   416 FKECPQLELLDLAFTRL-HINAPQSPFQNLHFLQ----VLNLTY------------------CF- 456

  Fly   527 RDSLILKIDCRNK-FVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISNITIAMLPKELRFLDL 590
                   :|..|: .:...|  |.|:..|.|.         |.....|:...:......|..|.|
Human   457 -------LDTSNQHLLAGLP--VLRHLNLKGN---------HFQDGTITKTNLLQTVGSLEVLIL 503

  Fly   591 RFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDC 655
            ....|:::|.:....|.|.| ...||.|...||                                
Human   504 SSCGLLSIDQQAFHSLGKMS-HVDLSHNSLTCD-------------------------------- 535

  Fly   656 PDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHL 720
                  .:|:|:....|                   |::|..|::..:|.:....:..:| .::|
Human   536 ------SIDSLSHLKGI-------------------YLNLAANSINIISPRLLPILSQQS-TINL 574

  Fly   721 LDNPWSCSCNDIEKINFMKSVSSSIVDFTEIKCSN-----GEKLVSINQHIVCPSDLFYYLALAI 780
            ..||..|:|::|..:.:.|.....:....|..|:|     |.||..:.  :.|.........|.:
Human   575 SHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVK--LSCGITAIGIFFLIV 637

  Fly   781 SLVATIIALNFLIWFRQPVLVWFYEH 806
            .|:...|.|.|.:.:   :|.|.|:|
Human   638 FLLLLAILLFFAVKY---LLRWKYQH 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 4/19 (21%)
leucine-rich repeat 346..367 CDD:275378 7/35 (20%)
leucine-rich repeat 563..583 CDD:275378 2/19 (11%)
leucine-rich repeat 585..610 CDD:275378 7/24 (29%)
leucine-rich repeat 611..622 CDD:275378 3/10 (30%)
TIR 823..960 CDD:214587
CD180NP_005573.2 leucine-rich repeat 38..57 CDD:275380 7/18 (39%)
LRR 1 54..75 6/31 (19%)
leucine-rich repeat 58..78 CDD:275380 6/30 (20%)
LRR 2 78..99 6/20 (30%)
leucine-rich repeat 79..102 CDD:275380 6/22 (27%)
LRR_8 102..161 CDD:290566 15/61 (25%)
LRR 3 102..123 6/23 (26%)
leucine-rich repeat 103..126 CDD:275380 6/25 (24%)
LRR 4 126..147 5/20 (25%)
leucine-rich repeat 127..150 CDD:275380 4/22 (18%)
LRR 5 150..171 8/20 (40%)
leucine-rich repeat 151..174 CDD:275380 7/22 (32%)
LRR 6 174..195 3/20 (15%)
leucine-rich repeat 175..195 CDD:275380 2/19 (11%)
leucine-rich repeat 196..234 CDD:275380 5/37 (14%)
LRR 7 201..221 4/19 (21%)
leucine-rich repeat 235..275 CDD:275380 9/41 (22%)
LRR 8 275..296 5/25 (20%)
leucine-rich repeat 276..299 CDD:275380 5/27 (19%)
LRR 9 299..320 3/20 (15%)
leucine-rich repeat 300..322 CDD:275380 3/21 (14%)
LRR 10 322..343 4/20 (20%)
LRR_8 323..382 CDD:290566 15/76 (20%)
leucine-rich repeat 323..371 CDD:275380 10/49 (20%)
LRR_RI 327..541 CDD:238064 55/316 (17%)
LRR 11 346..366 5/21 (24%)
LRR_8 371..432 CDD:290566 14/80 (18%)
LRR 12 371..391 4/35 (11%)
leucine-rich repeat 372..397 CDD:275380 5/40 (13%)
LRR 13 397..418 6/24 (25%)
leucine-rich repeat 398..421 CDD:275380 6/26 (23%)
LRR_8 420..481 CDD:290566 16/102 (16%)
LRR 14 421..442 5/21 (24%)
leucine-rich repeat 422..446 CDD:275380 5/24 (21%)
LRR 15 446..466 6/49 (12%)
leucine-rich repeat 447..470 CDD:275380 7/54 (13%)
LRR 16 470..493 6/31 (19%)
leucine-rich repeat 471..497 CDD:275380 5/34 (15%)
LRR_8 497..555 CDD:290566 19/115 (17%)
LRR 17 497..518 5/20 (25%)
leucine-rich repeat 498..521 CDD:275380 6/22 (27%)
LRR 18 521..544 9/61 (15%)
leucine-rich repeat 522..543 CDD:275380 8/59 (14%)
LRR 19 546..564 5/36 (14%)
TPKR_C2 577..626 CDD:301599 12/50 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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