DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr5b

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001124067.2	Gene:	tlr5b / 403139	ZFINID:	ZDB-GENE-040219-15	Length:	881	Species:	Danio rerio

Alignment Length:	972	Identity:	191/972 - (19%)
Similarity:	332/972 - (34%)	Gaps:	321/972 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IERDVHYINGPKSLKIIIQSNLYLNEIIEYINKTT-DNVNEIIINAYKTVENQQ--IALDNLIFN 176
            |.|.:|.:  |:....:...:|.||.|.| :|:|: ..:.::   .:..||.|.  :.:.|..|.
Zfish    41 INRGLHQV--PELPAHVNYVDLSLNSIAE-LNETSFSRLQDL---QFLKVEQQTPGLVIRNNTFR 99

  Fly   177 GKSHLRSLTFIGFQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTLQKSLEHLELDI--DNEV 239
            |.|.|..|.....|...|.|..|....||:.:.||.|.:..........|.|..||:.:  ||.:
Zfish   100 GLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNI 164

  Fly   240 ----DLKYFTNFS-----SLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYII 295
                ...:|.|..     .|.|.||::          ||.....||    .|.....|......:
Zfish   165 KKIQPASFFLNMRRFHVLDLTFNKVKS----------ICEEDLLNF----QGKHFTLLRLSSITL 215

  Fly   296 DDLE------------------LNIDCSNLGL--------------LQIPPLPIPSYGGVKLNFS 328
            .|:.                  ..:|.|..|.              .:|..|.:.:...:..:|.
Zfish   216 QDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFG 280

  Fly   329 NNSLSQLPTMTLPGYKL--VKRLDVSRNRL----------------------------------- 356
            :.:.......|..|.:.  ||..|:|::::
Zfish   281 HTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGL 345

  Fly   357 -----TNLSINHLPA----------KLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQ-WTIH 405
                 .|||.|.|.:          ||:.||:|:|.|..:|:.....|..:.....|||. .::|
Zfish   346 THLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLPNLRKLNLTGNAVESVH 410

  Fly   406 C-DDKPLLNFFRHLKLII---RMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRK----QEY 462
            . ...|.||     ||.:   |:.|....|...|:|:.|...|.|......::..:|:    :..
Zfish   411 TFAALPNLN-----KLYLGKNRISSVSSLPNIAHNLSTLDLEFNKLHALSDLYTILREFPQIENI 470

  Fly   463 YL--------INEEQL-----LQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMA 514
            :|        .|::|:     ||.:|..|:::..|        |...|.:  |...||..::|::
Zfish   471 FLQGNTFSSCYNQKQIVLSDKLQLLHLGLSSMQLI--------WSEGKCL--NVFADLHQLQQLS 525

  Fly   515 APCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGK---QNMSSPMELHLSKNNISNI 576
                                            :.|...:.:.|   ::::|...|.||.|::..:
Zfish   526 --------------------------------LTANGLQSLPKDIFKDLTSLFFLDLSFNSLKYL 558

  Fly   577 TIAMLPKELRFLDLRFNNLVTLDDKV---LSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEP 638
            ...:.||.|:.|:|.:|::.::|..:   ||||       .|..|.:.|||.       |:|.:
Zfish   559 PTDVFPKSLQILNLDYNSIYSVDPNLFSTLSYL-------SLMNNDFRCDCD-------LKDFQ- 608

  Fly   639 LEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTAL 703
                                        ||                          |...|:|.
Zfish   609 ----------------------------TW--------------------------LNQTNVTF- 618

  Fly   704 SQKNRSSIENRSLKLHLLDNPWSCSCNDIEKINFMKSVSSSIVDFTEIKCSNGEKLVSINQHIVC 768
                          :|.:::....|..|...:..:||         .|:|.|.|:.....:
Zfish   619 --------------VHPIEDVTCASPEDQYMVPVVKS---------SIQCENEEEERRTEK---- 656

  Fly   769 PSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYEHGVCLSL---------SAKRELDKDKRF 824
                   |.|.:.:|.|::    :|.|....:|:....||...:         ..|||.....||
Zfish   657 -------LRLVLFIVCTVL----IILFTASTIVYISRRGVIFKMYKKLIGELVDGKREEPDPDRF 710

  Fly   825 --DAFLAFTHKDEALLEEFVDRLERGRPRF------QLCFYLRDWLAGESIPDCIGQSIKDSRRI 881
              |.:|.|:.||...:|..:  |:|...:|      :.||..||::.||.....:..:|::||:.
Zfish   711 LYDVYLCFSSKDMKWVERAL--LKRLDSQFSEHNTLRCCFEERDFIPGEDHLTNMRSAIQNSRKT 773

  Fly   882 IVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFDSLD-SELRTYMAFNTYL 942
            |.:::|:|:...|....|.||......:....|:|::..|:..:..|. .::|:::...:||
Zfish   774 ICVVSEHFLKDGWCLETFTLAQKRMQAELEDILVVLVVGNIPQYRLLKYKQVRSFIENRSYL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	3/19 (16%)
		leucine-rich repeat	346..367	CDD:275378	9/70 (13%)
		leucine-rich repeat	563..583	CDD:275378	4/19 (21%)
		leucine-rich repeat	585..610	CDD:275378	9/27 (33%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	34/129 (26%)
tlr5b	NP_001124067.2	leucine-rich repeat	55..78	CDD:275380	7/23 (30%)
		leucine-rich repeat	79..103	CDD:275380	6/26 (23%)
		LRR_8	102..164	CDD:290566	18/61 (30%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		leucine-rich repeat	128..153	CDD:275380	6/24 (25%)
		leucine-rich repeat	154..178	CDD:275380	6/23 (26%)
		leucine-rich repeat	179..236	CDD:275380	11/70 (16%)
		LRR_RI	<224..478	CDD:238064	45/258 (17%)
		LRR_8	298..356	CDD:290566	7/57 (12%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		leucine-rich repeat	324..347	CDD:275380	0/22 (0%)
		LRR_8	346..404	CDD:290566	15/57 (26%)
		leucine-rich repeat	348..371	CDD:275380	5/22 (23%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		LRR_8	394..451	CDD:290566	16/61 (26%)
		leucine-rich repeat	396..417	CDD:275380	4/20 (20%)
		leucine-rich repeat	441..482	CDD:275380	6/40 (15%)
		leucine-rich repeat	494..520	CDD:275380	8/35 (23%)
		LRR_8	520..577	CDD:290566	14/88 (16%)
		leucine-rich repeat	521..544	CDD:275380	3/54 (6%)
		leucine-rich repeat	545..563	CDD:275380	4/17 (24%)
		leucine-rich repeat	567..587	CDD:275380	5/19 (26%)
		LRRCT	596..645	CDD:214507	17/134 (13%)
		TIR	712..846	CDD:214587	32/126 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920