DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and tlr5a

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_001919052.2	Gene:	tlr5a / 403138	ZFINID:	ZDB-GENE-040219-14	Length:	881	Species:	Danio rerio

Alignment Length:	1029	Identity:	199/1029 - (19%)
Similarity:	369/1029 - (35%)	Gaps:	350/1029 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ATNEYHLIMRDGHLEVNWKIPDPNIFIISPISKENRL-KLNELIVSDTSYPIRAVDYLRQLGVET 101
            :|:.|.....|..|:   ::|..:.:|.:....:||: :|||     ||:     .:|..|.|..
Zfish    26 STDGYFAFCMDRGLQ---EVPKISTYITNVDLSKNRIAELNE-----TSF-----SHLEALEVLI 77

  Fly   102 VTRFENQINSFKVIERDVHYINGPKSLKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKTVENQ 166
            :                :|...|     ::|:.|.::.         ..|:..:.::     .|.
Zfish    78 L----------------MHQTPG-----LVIRRNSFMR---------LSNLTSLQLD-----YNH 107

  Fly   167 QIALDNLIFNGKSHLRSLT------------------FIGFQIENLS------TKPFAQFINLKR 207
            .:.:|...|||.|.|::||                  .:..::.:||      .:|.:.|:|::|
Zfish   108 HLRIDAGAFNGLSDLKNLTLTQCGLDDSLLSGNFLKPLMSLEMLDLSRNNIRRVQPASFFLNMRR 172

  Fly   208 MVLTNCTVRNLTFLRTLQKSLEHLELDIDNEVDLKYFT--NFSSLKFMKVRNY----------IP 260
            .     .|.:|||.:.  ||:  .|.|:.| ...|:||  ..||:....:..|          ..
Zfish   173 F-----HVLDLTFNKV--KSI--CEEDLLN-FQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFK 227

  Fly   261 NKNFTALICTHKNCNF---IRGINGLECPKLCQCLYIID---------DLELNIDCSNLGLLQIP 313
            |.:.|.|..:....|.   .|..:.:...|: |.|.|.:         |...:.|.|....|:
Zfish   228 NTSITTLDLSGNGFNVDMAKRFFDAISSTKI-QSLIISNTYRIGKSSGDNSKDPDKSTFSGLK-- 289

  Fly   314 PLPIPSYGGVKLNFSNNS-----------LSQLPTMTLPGYKLVK-------------RLDVSRN 354
                 |.|....:.||:|           ||.|..:||...::.|             :|::|:|
Zfish   290 -----SSGIKSFDLSNSSIFSLTYSVFSYLSDLEQITLAESQINKIENNAFLGMTNLLKLNLSKN 349

  Fly   355 RLTNL---SINHLPAKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFR 416
            .|..:   :..:|.. |:.||:|:|.|..:|:...:.|..:.....|||.             ..
Zfish   350 FLGYIDFRTFQNLKG-LEVLDLSYNHIWRLGSQSFQGLPNLLSLNLTGNS-------------LG 400

  Fly   417 HLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNL 481
            |                :::...|||....:||.:.|     :..|.:.|..:.|:::..:.|.:
Zfish   401 H----------------VYTFATLPKLEKLYLGDNNI-----QYVYEIPNIAKHLKTLDLQFNQI 444

  Fly   482 NTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKID----------- 535
            .::..:|..::...:....|.|...|.|       ||.......|::..:|.:.
Zfish   445 ASMSELYTILDEFPQIEEVVFRGNQLLY-------CPQDNHEVLSQNIQVLDLSFAGLQVIWSEG 502

  Fly   536 -CRNKF--VYNFPDIVARNSRLMGK------QNMSSPMELHLSKNNISNITIAMLPKELRFLDLR 591
             |.|.|  ::.. :::..:|.|:..      ::::|.:.|.||.|::..:...:.||.|:.|.|.
Zfish   503 KCLNVFDDLHQL-EVLHLSSNLLQSLPKDIFKDLTSLLILDLSFNSLKYLPTDVFPKTLQVLHLD 566

  Fly   592 FNNLVTLDDKV---LSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPT 653
            :|::.::|..:   ||||       .|..|.:.|||.       |:|.:
Zfish   567 YNSIYSVDPNLFSTLSYL-------SLMNNDFRCDCD-------LKDFQ---------------- 601

  Fly   654 DCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKL 718
                         ||                          |...|:|.:     .|||:
Zfish   602 -------------TW--------------------------LNQTNITFV-----HSIED----- 617

  Fly   719 HLLDNPWSCSCNDIEKINFMKSVSSSIVDFTEIKCSNGEKLVSINQHIVCPSDLFYYLALAISLV 783
                    .:|...|....:..||||      |:|.:.|:.....:           |.|.:.:.
Zfish   618 --------VTCASPEDQYMVPVVSSS------IQCEDEEEERRTEK-----------LRLVLFIS 657

  Fly   784 ATIIALNFLIWFRQPVLVWFYEHGVCLSLSAKRELDKDKR-----------FDAFLAFTHKDEAL 837
            .|::    :|.|....:|:....||...:..|.....|.:           :|.:|.|:.:|...
Zfish   658 CTVL----IILFSASTIVYISRRGVIFKIYKKLIGKFDNKPQEEPDANGFLYDVYLCFSSRDMKW 718

  Fly   838 LEEFVDRLERGRPRF------QLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGR 896
            :|..:  |:|...:|      :.||..||::.||.....:..:|:.||:.|.:::::|:...|..
Zfish   719 VERAL--LKRLDSQFSEHNTLRCCFEERDFIPGEDHLTNMRNAIQHSRKTICVVSKHFLKDGWCL 781

  Fly   897 LEFRLALHATSRDRCKR-------LIVVLYPNVKNFDSLDSE-LRTYMAFNTYL 942
            ..|.||       :|:.       |:|::..|:..:..|..| ||:::...:||
Zfish   782 ETFTLA-------QCRMLVELKDILVVLVVGNIPQYRLLKYEQLRSFIENRSYL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	8/30 (27%)
		leucine-rich repeat	346..367	CDD:275378	6/36 (17%)
		leucine-rich repeat	563..583	CDD:275378	4/19 (21%)
		leucine-rich repeat	585..610	CDD:275378	9/27 (33%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	33/145 (23%)
tlr5a	XP_001919052.2	LRR_8	50..107	CDD:290566	15/101 (15%)
		leucine-rich repeat	50..72	CDD:275380	8/31 (26%)
		leucine-rich repeat	73..97	CDD:275380	6/53 (11%)
		LRR_8	96..158	CDD:290566	12/66 (18%)
		leucine-rich repeat	98..121	CDD:275380	5/27 (19%)
		leucine-rich repeat	122..147	CDD:275380	3/24 (13%)
		leucine-rich repeat	148..172	CDD:275380	5/23 (22%)
		leucine-rich repeat	173..230	CDD:275380	16/66 (24%)
		LRR_RI	<218..478	CDD:238064	58/309 (19%)
		LRR_8	291..349	CDD:290566	12/57 (21%)
		leucine-rich repeat	297..316	CDD:275380	4/18 (22%)
		leucine-rich repeat	317..340	CDD:275380	4/22 (18%)
		LRR_8	339..399	CDD:290566	16/73 (22%)
		leucine-rich repeat	341..364	CDD:275380	5/22 (23%)
		leucine-rich repeat	365..388	CDD:275380	8/22 (36%)
		LRR_8	387..444	CDD:290566	14/90 (16%)
		leucine-rich repeat	389..410	CDD:275380	5/49 (10%)
		leucine-rich repeat	411..433	CDD:275380	5/26 (19%)
		leucine-rich repeat	434..513	CDD:275380	14/85 (16%)
		leucine-rich repeat	485..499	CDD:275378	1/13 (8%)
		LRR_8	513..570	CDD:290566	13/57 (23%)
		leucine-rich repeat	514..537	CDD:275380	2/23 (9%)
		leucine-rich repeat	538..559	CDD:275380	5/20 (25%)
		leucine-rich repeat	560..581	CDD:275380	5/20 (25%)
		LRRCT	589..638	CDD:214507	21/134 (16%)
		TIR	705..839	CDD:214587	33/133 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920