DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr8a

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_001920594.5	Gene:	tlr8a / 403137	ZFINID:	ZDB-GENE-040219-13	Length:	1019	Species:	Danio rerio

Alignment Length:	1106	Identity:	220/1106 - (19%)
Similarity:	392/1106 - (35%)	Gaps:	382/1106 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LKIIIQSNLYLNEIIEYINKTT-----DNV--NEIIINA---YKTVENQQIALDNLIFNGKSHLR 182
            |.:|::..|.|:|:...|.||.     :|:  ..:::|.   ...|..|.:|....|...:::::
Zfish     9 LILILKLTLALSELNVRILKTQPCDIHENITAETVVVNCRGRKLKVLPQFLANTTYIDLSENYIK 73

  Fly   183 SLTFIGFQ-IENLSTKPFAQFINL------KRMVLTNCTVRNLTFLRTLQ--------------K 226
            :||...|. :|||:      .:||      :.:|:......|||.||.|.              |
Zfish    74 NLTVQSFHGLENLT------LLNLNWLNQNREVVIAKGVFSNLTKLRVLDLNGIKLKYIPKDIPK 132

  Fly   227 SLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQC 291
            :||.|.| ::|::.....|.|..:|.:.|. |:.|           ||.:..
Zfish   133 NLEKLSL-VENKITWINLTTFEHVKNLSVL-YLSN-----------NCYYWN------------- 171

  Fly   292 LYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRL 356
                       .||.                 :......|||.|..:        |||.:|.|.|
Zfish   172 -----------PCSR-----------------RYRIEKGSLSYLVNL--------KRLTLSFNNL 200

  Fly   357 TNLSINHLPAKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLL--------- 412
            |.:.|. ||..|:.|::..|.:..:|....:.|..:.:.|..||....|....|.:
Zfish   201 TQVPIG-LPVSLERLELGSNSLTYIGEHDFRGLFNLTVLKIQGNCPRCHTAPYPCIPCKNTSIEI 264

  Fly   413 -----NFFRHLKLIIRMKSAEMK---PMFLHSLTELPKGFLKFL--------GKHFIWLGVRKQE 461
                 :..|:|. |:.:....:|   |.:..:|:.|.:.||.|.        ....::||    .
Zfish   265 HPQAFSDLRNLH-ILHLAGNSIKSINPAWFANLSNLQQLFLSFNLLFSAITDPADTVFLG----N 324

  Fly   462 YYLINEEQL------------------------LQSMH------RKLN----------------- 479
            ..|:.:..|                        |:|:|      ||:.
Zfish   325 LPLLTKLDLSYNFAFKTYPLTVVLSPGFANLTSLRSLHLRGLVFRKIQKDTFKSLFDLQHLNVLD 389

  Fly   480 -NLNTIMSIYKYMEWLHRKLIFV--NREYDL-----------------FYIRQMAAP-----CPH 519
             .:|.|:....|: :.|.:|:::  ||.|.:                 ..:..||.|     .|.
Zfish   390 VGVNFIVFATSYI-FQHVRLLYLAENRLYPVTVNGELSKATFVGSNHRSIMPLMAEPLDTFDAPK 453

  Fly   520 ---KCECC-------YSRDSLIL----------KIDC----RNKF-------------------- 540
               |.||.       .||::|.|          .|.|    ||.|
Zfish   454 NLVKSECYNAGRVLDLSRNNLFLISPEQFDTYGNISCLNLSRNGFSTAPNGSEFTSLPNLKYLDL 518

  Fly   541 VYNFPDIVARNSRLMGKQNMSSPMELHLSKNN----ISNIT-----IAMLPKELRFLDLRFNNLV 596
            .:|..|:...|:    .:.:.|...|.:|.|:    ::.:|     :..|| .|:.|::.||::.
Zfish   519 SFNKVDLAYDNA----FRELQSLEVLDISYNSHYFTVAGVTHNMMFLQYLP-SLKVLNMSFNSIN 578

  Fly   597 TLDDKVLS--YLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPL-------------------E 640
            ||..|.:|  .|::...:....|..|.  .|..:.:.|.::...|                   :
Zfish   579 TLTTKTMSSKSLRELQFRGNKLGRMWR--DKDNTYVMIFKNFTNLIHLDISNNSIGKIPYTVYTQ 641

  Fly   641 YDVTLKRCNISPTDCPDVCVCCLDNLTWPSF---------------IVDCRGEGLLQMPSLSSRV 690
            ..:|::|..:|...        |.|:.|...               |::......:.:|||.
Zfish   642 LPITIQRLQMSHNQ--------LANINWTMLRRFQNLRELILHDNNIIEIASNLSVDVPSLE--- 695

  Fly   691 TYVDLRNNNLTALS---------------------QKNRSSIENRS-LK-LHLLDNPWSCSCNDI 732
             .::|::|.::.|:                     ..|:|:....| || |.|..||:.|:||.:
Zfish   696 -LLNLQHNRISKLAIGFLQGVVNLKELDLSYNYLITVNQSTFPTESDLKMLWLHGNPFHCTCNLL 759

  Fly   733 EKINFMKSVSSSIVDF-TEIKCSNGEK---LVSINQHI-VCPSD----LFYYLALAISLVATIIA 788
            |.:.::...:..|... |.:.|:..|:   |..|...| .|..|    :.|:::.|..:..|..|
Zfish   760 EFVLWILDTNVKIPRLVTGVTCTMPEERKGLAVIKFDIQECIDDQLAFVAYFISAACIICTTFAA 824

  Fly   789 LNFLIWFRQPVLVWFYEHGVCLSLSAK----RELDKDK-RFDAFLAFTHKDEALLEEFVDRL--- 845
            :...:::.....:::|       |.|:    ::|..:. .:|||:.:..||..:.:..::.|
Zfish   825 ITMHLFYWDVSYLYYY-------LKARFTGYQQLSSESCIYDAFITYDTKDPQVSDWVLNHLRVQ 882

  Fly   846 --ERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLAL---HA 905
              ||......:|...|||:.|..:.|.:.|||::||:.:.::||.::||.    .|:||:   |.
Zfish   883 LEERSELFLPICLEERDWIPGSPVLDSLTQSIQNSRKTVFVLTEGYVNSG----SFKLAVFLAHQ 943

  Fly   906 TSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYLERSHPN-----FW----------NKLIY 955
            ...:..:.:||:|........|....||..:...:.||..|.:     ||          |:.:|
Zfish   944 RLLEENEDVIVLLLLEPVLQHSHFVRLRRRLCARSILEWPHSSSAEAWFWQSLRNAIRVDNQALY 1008

  Fly   956 S 956
            |
Zfish  1009 S 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	4/19 (21%)
		leucine-rich repeat	346..367	CDD:275378	10/20 (50%)
		leucine-rich repeat	563..583	CDD:275378	5/28 (18%)
		leucine-rich repeat	585..610	CDD:275378	9/26 (35%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	41/157 (26%)
tlr8a	XP_001920594.5	NEL	<15..>226	CDD:330839	60/279 (22%)
		leucine-rich repeat	62..112	CDD:275380	12/55 (22%)
		leucine-rich repeat	113..133	CDD:275380	3/19 (16%)
		LRR_8	133..200	CDD:316378	24/128 (19%)
		leucine-rich repeat	134..157	CDD:275380	7/23 (30%)
		leucine-rich repeat	158..189	CDD:275380	11/83 (13%)
		PLN00113	189..>702	CDD:331614	98/546 (18%)
		leucine-rich repeat	190..234	CDD:275380	15/52 (29%)
		leucine-rich repeat	235..274	CDD:275380	5/38 (13%)
		leucine-rich repeat	275..298	CDD:275380	5/23 (22%)
		leucine-rich repeat	299..327	CDD:275380	6/31 (19%)
		leucine-rich repeat	328..357	CDD:275380	1/28 (4%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	465..487	CDD:275380	4/21 (19%)
		leucine-rich repeat	488..512	CDD:275380	5/23 (22%)
		leucine-rich repeat	513..536	CDD:275380	3/26 (12%)
		leucine-rich repeat	537..566	CDD:275380	6/29 (21%)
		leucine-rich repeat	567..620	CDD:275380	13/54 (24%)
		leucine-rich repeat	621..645	CDD:275380	1/23 (4%)
		leucine-rich repeat	646..669	CDD:275380	5/30 (17%)
		leucine-rich repeat	670..693	CDD:275380	1/22 (5%)
		LRR_8	692..752	CDD:316378	14/63 (22%)
		leucine-rich repeat	694..717	CDD:275380	4/26 (15%)
		leucine-rich repeat	718..736	CDD:275380	2/17 (12%)
		TPKR_C2	750..>789	CDD:326558	10/38 (26%)
		TIR	858..1000	CDD:214587	38/145 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820