Protein Alignment MstProx and tlr22

DIOPT Version :10

• Sequence 1: NP_649719.2
• Gene: MstProx / 40890
• FlyBaseID: FBgn0015770
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: NP_001122147.2
• Gene: tlr22 / 403135
• ZFINID: ZDB-GENE-040220-5
• Length: 955
• Species: Danio rerio
• Alignment Length: 1074
• Identity: 212/1074 - (19%)
• Similarity: 381/1074 - (35%)
• Gaps: 336/1074 - (31%)

  Fly    62 IFIISPISKENRLKLNELIVSDTSYPIRAVDYL--RQLGVETVTRFEN-------QINSFKVIER 117
            |.|.:.:|..:...|....:|.:...|:....:  .::...|:.|..|       ..|||..|:
Zfish    19 ITICAMVSPCSTFSLTNCTISSSQKDIKTQPKVLCYKMNFFTIPRVPNNTWILDISFNSFAQIQ- 82

  Fly   118 DVHYINGPKSLKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKTV---------ENQQIALDNL 173
                         |...|:.||  ::|:|.:.:.:::|...|:.::         .|:..|:.|.
Zfish    83 -------------IEDLNILLN--LQYLNVSNNKISKIQDGAFGSLFNLTDLNLASNRLNAVSNG 132

  Fly   174 IFNG----------------------------------KSHLRSL--------------TFIG-- 188
            :..|                                  |:|||.:              .:||
Zfish   133 MLRGLTNLLVLRLDRNYISVIKESAFSTLHSLQVLNLSKNHLRHIDDVKPVLASLYLEELYIGSN 197

  Fly   189 ----FQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTLQKSLEHLELDID--------NEVDL 241
                |....|||||    ::|||:.|:|...........:..:|.||:|...        |..:.
Zfish   198 YFNVFNSSELSTKP----LSLKRLDLSNNRFAAFQLTNNIFPTLNHLDLSYCGHNGTMAWNVTEK 258

  Fly   242 KYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGING-----------LECPKLCQCLYII 295
            .|..:..:|.||.|...|...: ..|...:...|.|| :||           ..|..:.:.|.:|
Zfish   259 SYLASVKTLYFMDVNMSIQTAD-NVLQSFNNTLNKIR-LNGNVRLNKTSLLLSVCSPMLRVLRLI 321

  Fly   296 DDLELNI------DCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRN 354
            .....::      .||.|.               :|:...|.:|.|......|:|.:|:|.:..|
Zfish   322 ATKIKHLTNHMFDPCSELS---------------ELDLGGNEISNLSQSMFRGFKQLKKLQLQIN 371

  Fly   355 RLTNLSIN-HLPAKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHL 418
            :||.::.: .:...|:::|:|.|.|..:.                       |:|      |.:|
Zfish   372 KLTRVTNSFQILTSLEFIDLSRNHIHKLS-----------------------CND------FANL 407

  Fly   419 KLIIRMKSAEMKPMFLHS--LTELPKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNL 481
                    .::|.::|:|  ::.:.....|.|                    :.|:.:....|||
Zfish   408 --------TQVKTLYLYSNKISSIRSCLFKDL--------------------KSLEVLRLGTNNL 444

  Fly   482 NTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPD 546
            ..|..            :|.|..|   :::::        :..|::.|||     ::....|.|.
Zfish   445 LKIDD------------VFSNGPY---FLKEL--------QLSYNKLSLI-----KSHTFGNLPQ 481

  Fly   547 IVARNSRLMGKQNMSSPME------------LHLSKNNISNITIAMLPK------ELRFLDLRFN 593
            :    :.|..:.|..|.:|            |.||.|.|:..|:...|.      .|:.|||..|
Zfish   482 L----NNLSLEDNQISEIEGYAFGGLENLTSLFLSSNKITGKTLTTHPNVFSGMPNLQNLDLFAN 542

  Fly   594 NLVTLDDKV-------LSYLKKNSIKTKLSG----------------------------NP---- 619
            ::....||:       |..|::.|:.::..|                            ||
Zfish   543 SISFAYDKLKYPLFKDLKNLRELSLYSQRRGIGQLPSNLLEGLSSLQMFYIGNTNLNQLNPNLFN 607

  Fly   620 -----WNCDCKSRSVLSILRDHEPLEYDV-----TLKRCNISPTDCPDVCVCCLDNLTWPSFIVD 674
                 |..|....:    ||:.:.:..::     .|.:..||.|....:           :|::
Zfish   608 FTPQLWFLDLSKNA----LREDDAIPPELFHPIPNLTKLIISRTQLRSL-----------NFLL- 656

  Fly   675 CRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLDNPWSCSCNDIEKINF-M 738
              |..|.::.:|.:....:|  :.|.|.:....|.::      |.|.:|.::|.||:...|:: .
Zfish   657 --GANLNKLSTLRASGNEID--SVNETLIKSLPRLAV------LDLQNNTFTCDCNNAFFIDWAK 711

  Fly   739 KSVSSSIVDFTEIKCS-----NGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIW--FR 796
            |:.|:.:...:...||     .|..|...|.. .|..:..|...:..|::..:..|...||  .|
Zfish   712 KNESTQVYYLSRYTCSYPRTLRGTSLAEFNTD-SCTFNWDYICFVCSSILVILTLLLSFIWNFLR 775

  Fly   797 QPVLVWFYEHGVCLSLSAKRELDKDKRFDAFLAFTHKDEA-LLEEFVDRLERGRPRFQLCFYLRD 860
            ..|:..:|.....|..|.:.:..:..::|||:::...||| ::||.:.:|| |...::||.:.||
Zfish   776 YQVVYTYYLFLAFLYDSRRNQSGQTFQYDAFISYNTLDEAWVMEELIPKLE-GEQGWRLCLHHRD 839

  Fly   861 WLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNF 925
            :..|..|.|.|...|..||:.|.|:|.|::.|.|...|.::|......::...||:|...::...
Zfish   840 FEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCSSEVQVASFRLFDEQKDVLILVFLEDIPTH 904

  Fly   926 D-SLDSELRTYMAFNTYLERSHPN-----FWNKL 953
            . |....||..:...||:....|.     ||.||
Zfish   905 QLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKL 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	PRK15370	<315..>398	CDD:185268	16/83 (19%)
		leucine-rich repeat	325..345	CDD:275378	5/19 (26%)
		leucine-rich repeat	346..367	CDD:275378	5/21 (24%)
		TIR	823..960	CDD:214587	43/138 (31%)
tlr22	NP_001122147.2	LRR	<70..>242	CDD:443914	36/191 (19%)
		leucine-rich repeat	71..91	CDD:275380	6/33 (18%)
		leucine-rich repeat	92..115	CDD:275380	4/22 (18%)
		leucine-rich repeat	116..139	CDD:275380	4/22 (18%)
		leucine-rich repeat	140..163	CDD:275380	0/22 (0%)
		leucine-rich repeat	164..213	CDD:275380	12/52 (23%)
		leucine-rich repeat	214..338	CDD:275380	26/125 (21%)
		LRR	283..698	CDD:443914	94/545 (17%)
		leucine-rich repeat	339..362	CDD:275380	6/37 (16%)
		leucine-rich repeat	363..385	CDD:275380	5/21 (24%)
		leucine-rich repeat	386..409	CDD:275380	9/59 (15%)
		leucine-rich repeat	410..433	CDD:275380	5/42 (12%)
		leucine-rich repeat	434..457	CDD:275380	8/37 (22%)
		leucine-rich repeat	458..481	CDD:275380	5/35 (14%)
		leucine-rich repeat	482..505	CDD:275380	4/26 (15%)
		leucine-rich repeat	506..533	CDD:275380	7/26 (27%)
		leucine-rich repeat	534..561	CDD:275380	8/26 (31%)
		leucine-rich repeat	562..587	CDD:275380	3/24 (13%)
		leucine-rich repeat	588..606	CDD:275380	2/17 (12%)
		leucine-rich repeat	612..638	CDD:275380	4/29 (14%)
		leucine-rich repeat	639..662	CDD:275380	7/36 (19%)
		leucine-rich repeat	663..686	CDD:275380	4/24 (17%)
		PCC	669..>737	CDD:188093	16/75 (21%)
		leucine-rich repeat	687..705	CDD:275380	6/23 (26%)
		TIR	802..945	CDD:214587	43/138 (31%)