Protein Alignment MstProx and tlr19.1

DIOPT Version :10

• Sequence 1: NP_649719.2
• Gene: MstProx / 40890
• FlyBaseID: FBgn0015770
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: XP_073780929.1
• Gene: tlr19.1 / 403134
• ZFINID: ZDB-GENE-040220-3
• Length: 984
• Species: Danio rerio
• Alignment Length: 1125
• Identity: 238/1125 - (21%)
• Similarity: 396/1125 - (35%)
• Gaps: 390/1125 - (34%)

  Fly    19 ICND--TVASKTCDREAYDYIATNEYHLIMRDGHLEVNW---------KIPDPNIFI------IS 66
            |||.  |..:|.|        .|.|.||:.     ::.|         |.|..|..|      :|
Zfish    23 ICNVVLTRITKRC--------ITIEEHLLK-----QMPWTPHCLHYPGKGPYANCNITDLSTDLS 74

  Fly    67 PISKENRLKLNELIVSD-TSYPIRAVDYLRQLGVETV--TRFEN-QINSFKVIERDVHYINGPKS 127
            .:..|.|   ...:..| ||.|.:|..:|..|.|..:  .|.|. |..:|:          |..:
Zfish    75 QVGFEVR---TLCVFGDITSIPAKAFSHLPSLEVLHIDGIRLERVQAGAFE----------GLPN 126

  Fly   128 LKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQIE 192
            ||.:  |.|:.:|:                  |:.|.     :||..|.|.::|..|:..|..:.
Zfish   127 LKYL--SMLFSDEL------------------YRLVR-----IDNRSFAGLNNLEELSLTGLMLL 166

  Fly   193 NLSTKPFAQFINLKRMVLTN----------CTVRN-LTFLRTLQKSLEHLELDIDNEVDLKYFTN 246
            |.|:..|...::|.|:.:..          |.:.| :|.||       ||.:: |:|:
Zfish   167 NGSSGIFDPLVSLIRLDIVRTCAQDLGEIFCCISNGMTRLR-------HLNVE-DSEI------- 216

  Fly   247 FSSLKFMKVRNYIPNKNFTALICTHKNCNF-IRGINGLECPKLCQCLYII--------------- 295
                      :.|.||.     |...:..: :..::|:      |.||:|
Zfish   217 ----------STIENKG-----CPGGSMTWPLTALSGV------QNLYLIGNNIKYIQANSLIIF 260

  Fly   296 ---DDLELNIDCSNLGLL------QIPPLPIPSYGGVKLNFSNN--------------------- 330
               ..|.|..:..:||.:      ::..|.:.  |.|...:|.|
Zfish   261 QNLSSLFLEFEGKSLGSIWESGVGKVNDLTLK--GKVLKKYSTNFKDLCHLVSSLYSQSLSLVYT 323

  Fly   331 SLSQLPTMTLP--GYKLVKRLDVSRNRLTNLSINHLPAKLD-------YLDVSFNEIINMGNDVI 386
            |:.:|....|.  |.||.|.| :..:::.||......:||:       |:.::......:.|..:
Zfish   324 SIDRLTAEDLKDCGTKLTKLL-IQNSKIDNLDFRFWTSKLEMQALQMAYMKLTDAPFCFVANSTM 387

  Fly   387 KYLRTVPIFKQTGNQWT-IHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGK 450
            ..|.::.:   |||..| |..|....:.|...|.|    ....:|.:.||:...||:..:..|..
Zfish   388 WSLTSLDL---TGNSITNIEGDQFACMPFLEQLYL----SQNAIKTLQLHAFRGLPRLKILQLDS 445

  Fly   451 HFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAA 515
            :.||       ....|:.:.|:::...|.|.|.|.:|.....|..|:|
Zfish   446 NKIW-------QLSANDFKNLRALEVLLINDNIIETIETGTFWDQREL----------------- 486

  Fly   516 PCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKN----NIS-- 574
                 ||..:.|...:.::...|.| :.||..:.|.|           ::.|...|    |.|
Zfish   487 -----CELSFGRLEYVYELHLENIF-FEFPPKLQRLS-----------IDAHYGTNIYIGNASPP 534

  Fly   575 NITIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCD---CKSRSVLSILRDH 636
            |.|.|:   ||....|.|   |..|..||..:::..:         ||.   ||...:.....:.
Zfish   535 NGTFAL---ELNGERLGF---VGCDSDVLMAVRELKV---------NCTYFLCKDSFMAPYFLNL 584

  Fly   637 EPLEYDVTLKRCNISPTDCPDVCVCCLDN-----------LTWPSF-----------------IV 673
            |.||.....:|..::        ...::|           |.:|::                 :|
Zfish   585 ESLEISGGAERAPLN--------YATINNLHHLKHLKLARLNFPNYTESRSAFWNLTQLQTLVVV 641

  Fly   674 DCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIEN------RSLKLHLLDN-PWSCSCND 731
            :|.       .|..::..:.||.:..|..|...:...:.:      ..||..:||. .:.|||.:
Zfish   642 NCH-------LSFLTKSMFRDLTSLQLLRLYSDSPLILTDGVFGVLPVLKAFILDRVDFQCSCEN 699

  Fly   732 --------------------------IEKINFMKSVSSSIVDFTEIKCSNGEKLVSINQHIVCPS 770
                                      .:|:||:.::               |||...:...:|
Zfish   700 GWLLDWADSTEKVQVIYLQKQQCVWHYQKLNFLATM---------------EKLCQTDAQYIC-- 747

  Fly   771 DLFYYLALAIS---LVATIIALNFLIWFRQPVLVWFYEHGVCLSLSA-------------KRELD 819
                |:|.|.|   |::..:...|..|   |.||.|      |.|..             :|.::
Zfish   748 ----YVATASSISLLLSAAVGYQFARW---PSLVLF------LRLKGWMERRFGRRWNRRRRRME 799

  Fly   820 KD------KRFDAFLAFTHKDEA-LLEEFVDRL-ERGRPRFQLCFYLRDWLAGESIPDCIGQSIK 876
            .|      .::|||::|..:||| :|.|...|| |:|.||.:||.:.||:..|:.|.|.|..||.
Zfish   800 DDYGEIEEMQYDAFVSFCSQDEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDIMDNITDSIH 864

  Fly   877 DSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFD-SLDSELRTYMAFNT 940
            :|:..:.|::..::.|.|..||.|:|.|....::..|||::...::..|: |....|...:...|
Zfish   865 NSQCTVCLISRRYLRSDWCGLEMRVATHRQLEEQKHRLILIFLQHISPFELSAFHRLAKLVRSRT 929

  Fly   941 YL-------ERSHPNFWNKL 953
            ||       :|.|  ||::|
Zfish   930 YLDWPEEEGDREH--FWDRL 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	PRK15370	<315..>398	CDD:185268	20/112 (18%)
		leucine-rich repeat	325..345	CDD:275378	6/42 (14%)
		leucine-rich repeat	346..367	CDD:275378	4/20 (20%)
		TIR	823..960	CDD:214587	48/141 (34%)
tlr19.1	XP_073780929.1	None