DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr19.1

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	1125	Identity:	238/1125 - (21%)
Similarity:	396/1125 - (35%)	Gaps:	390/1125 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ICND--TVASKTCDREAYDYIATNEYHLIMRDGHLEVNW---------KIPDPNIFI------IS 66
            |||.  |..:|.|        .|.|.||:.     ::.|         |.|..|..|      :|
Zfish    23 ICNVVLTRITKRC--------ITIEEHLLK-----QMPWTPHCLHYPGKGPYANCNITDLSTDLS 74

  Fly    67 PISKENRLKLNELIVSD-TSYPIRAVDYLRQLGVETV--TRFEN-QINSFKVIERDVHYINGPKS 127
            .:..|.|   ...:..| ||.|.:|..:|..|.|..:  .|.|. |..:|:          |..:
Zfish    75 QVGFEVR---TLCVFGDITSIPAKAFSHLPSLEVLHIDGIRLERVQAGAFE----------GLPN 126

  Fly   128 LKIIIQSNLYLNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQIE 192
            ||.:  |.|:.:|:                  |:.|.     :||..|.|.::|..|:..|..:.
Zfish   127 LKYL--SMLFSDEL------------------YRLVR-----IDNRSFAGLNNLEELSLTGLMLL 166

  Fly   193 NLSTKPFAQFINLKRMVLTN----------CTVRN-LTFLRTLQKSLEHLELDIDNEVDLKYFTN 246
            |.|:..|...::|.|:.:..          |.:.| :|.||       ||.:: |:|:
Zfish   167 NGSSGIFDPLVSLIRLDIVRTCAQDLGEIFCCISNGMTRLR-------HLNVE-DSEI------- 216

  Fly   247 FSSLKFMKVRNYIPNKNFTALICTHKNCNF-IRGINGLECPKLCQCLYII--------------- 295
                      :.|.||.     |...:..: :..::|:      |.||:|
Zfish   217 ----------STIENKG-----CPGGSMTWPLTALSGV------QNLYLIGNNIKYIQANSLIIF 260

  Fly   296 ---DDLELNIDCSNLGLL------QIPPLPIPSYGGVKLNFSNN--------------------- 330
               ..|.|..:..:||.:      ::..|.:.  |.|...:|.|
Zfish   261 QNLSSLFLEFEGKSLGSIWESGVGKVNDLTLK--GKVLKKYSTNFKDLCHLVSSLYSQSLSLVYT 323

  Fly   331 SLSQLPTMTLP--GYKLVKRLDVSRNRLTNLSINHLPAKLD-------YLDVSFNEIINMGNDVI 386
            |:.:|....|.  |.||.|.| :..:::.||......:||:       |:.::......:.|..:
Zfish   324 SIDRLTAEDLKDCGTKLTKLL-IQNSKIDNLDFRFWTSKLEMQALQMAYMKLTDAPFCFVANSTM 387

  Fly   387 KYLRTVPIFKQTGNQWT-IHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGK 450
            ..|.::.:   |||..| |..|....:.|...|.|    ....:|.:.||:...||:..:..|..
Zfish   388 WSLTSLDL---TGNSITNIEGDQFACMPFLEQLYL----SQNAIKTLQLHAFRGLPRLKILQLDS 445

  Fly   451 HFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAA 515
            :.||       ....|:.:.|:::...|.|.|.|.:|.....|..|:|
Zfish   446 NKIW-------QLSANDFKNLRALEVLLINDNIIETIETGTFWDQREL----------------- 486

  Fly   516 PCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKN----NIS-- 574
                 ||..:.|...:.::...|.| :.||..:.|.|           ::.|...|    |.|
Zfish   487 -----CELSFGRLEYVYELHLENIF-FEFPPKLQRLS-----------IDAHYGTNIYIGNASPP 534

  Fly   575 NITIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCD---CKSRSVLSILRDH 636
            |.|.|:   ||....|.|   |..|..||..:::..:         ||.   ||...:.....:.
Zfish   535 NGTFAL---ELNGERLGF---VGCDSDVLMAVRELKV---------NCTYFLCKDSFMAPYFLNL 584

  Fly   637 EPLEYDVTLKRCNISPTDCPDVCVCCLDN-----------LTWPSF-----------------IV 673
            |.||.....:|..::        ...::|           |.:|::                 :|
Zfish   585 ESLEISGGAERAPLN--------YATINNLHHLKHLKLARLNFPNYTESRSAFWNLTQLQTLVVV 641

  Fly   674 DCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIEN------RSLKLHLLDN-PWSCSCND 731
            :|.       .|..::..:.||.:..|..|...:...:.:      ..||..:||. .:.|||.:
Zfish   642 NCH-------LSFLTKSMFRDLTSLQLLRLYSDSPLILTDGVFGVLPVLKAFILDRVDFQCSCEN 699

  Fly   732 --------------------------IEKINFMKSVSSSIVDFTEIKCSNGEKLVSINQHIVCPS 770
                                      .:|:||:.::               |||...:...:|
Zfish   700 GWLLDWADSTEKVQVIYLQKQQCVWHYQKLNFLATM---------------EKLCQTDAQYIC-- 747

  Fly   771 DLFYYLALAIS---LVATIIALNFLIWFRQPVLVWFYEHGVCLSLSA-------------KRELD 819
                |:|.|.|   |::..:...|..|   |.||.|      |.|..             :|.::
Zfish   748 ----YVATASSISLLLSAAVGYQFARW---PSLVLF------LRLKGWMERRFGRRWNRRRRRME 799

  Fly   820 KD------KRFDAFLAFTHKDEA-LLEEFVDRL-ERGRPRFQLCFYLRDWLAGESIPDCIGQSIK 876
            .|      .::|||::|..:||| :|.|...|| |:|.||.:||.:.||:..|:.|.|.|..||.
Zfish   800 DDYGEIEEMQYDAFVSFCSQDEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDIMDNITDSIH 864

  Fly   877 DSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFD-SLDSELRTYMAFNT 940
            :|:..:.|::..::.|.|..||.|:|.|....::..|||::...::..|: |....|...:...|
Zfish   865 NSQCTVCLISRRYLRSDWCGLEMRVATHRQLEEQKHRLILIFLQHISPFELSAFHRLAKLVRSRT 929

  Fly   941 YL-------ERSHPNFWNKL 953
            ||       :|.|  ||::|
Zfish   930 YLDWPEEEGDREH--FWDRL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	6/42 (14%)
		leucine-rich repeat	346..367	CDD:275378	4/20 (20%)
		leucine-rich repeat	563..583	CDD:275378	7/25 (28%)
		leucine-rich repeat	585..610	CDD:275378	7/24 (29%)
		leucine-rich repeat	611..622	CDD:275378	0/10 (0%)
		TIR	823..960	CDD:214587	48/141 (34%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378	20/95 (21%)
		leucine-rich repeat	103..126	CDD:275380	7/32 (22%)
		leucine-rich repeat	127..154	CDD:275380	11/51 (22%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..238	CDD:275380	15/88 (17%)
		leucine-rich repeat	207..219	CDD:275378	5/36 (14%)
		leucine-rich repeat	239..265	CDD:275380	4/31 (13%)
		leucine-rich repeat	340..363	CDD:275380	6/23 (26%)
		leucine-rich repeat	364..389	CDD:275380	2/24 (8%)
		LRR_8	389..448	CDD:316378	16/65 (25%)
		leucine-rich repeat	390..413	CDD:275378	7/25 (28%)
		leucine-rich repeat	414..437	CDD:275378	6/26 (23%)
		LRR_8	436..>482	CDD:316378	11/52 (21%)
		leucine-rich repeat	438..461	CDD:275378	5/29 (17%)
		leucine-rich repeat	462..485	CDD:275378	6/22 (27%)
		leucine-rich repeat	540..562	CDD:275380	8/27 (30%)
		leucine-rich repeat	563..608	CDD:275380	9/61 (15%)
		leucine-rich repeat	609..634	CDD:275380	2/24 (8%)
		leucine-rich repeat	635..658	CDD:275380	5/29 (17%)
		TIR	809..952	CDD:214587	48/141 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010