DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr1

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001124065.1	Gene:	tlr1 / 403127	ZFINID:	ZDB-GENE-040220-1	Length:	795	Species:	Danio rerio

Alignment Length:	925	Identity:	177/925 - (19%)
Similarity:	335/925 - (36%)	Gaps:	291/925 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 INKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQIENLSTKPFAQFINLKRMV 209
            :|.::.|::.:..:...:.|:..::|        :|::||     ...:.:|.|..:|:||...:
Zfish    30 VNYSSQNLSSVPDDLKPSTEDLDLSL--------NHIQSL-----NCRDFNTTPRLRFLNLSWNI 81

  Fly   210 LTNCTVRNLTFLRTLQKSLEHLELD---IDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICTH 271
            |.|  :...||..|  .:||.|:|.   :.|..:..|..:...|:.:.    :.:..|:|:..
Zfish    82 LEN--IDRDTFTST--PALEMLDLSHNGLQNLSEQPYLLHLGCLELLD----LSSNRFSAMAL-- 136

  Fly   272 KNCNFIRGINGLECPKLCQCLYI-IDDLELNI-DCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQ 334
                      |.|...|.:..:: :....::| |.:::..|.:..|.|.:.|  .|.:..|||..
Zfish   137 ----------GEEFSMLKRLQWLGLSAKSISIQDFTHISNLTLRTLFINADG--LLTYEGNSLDD 189

  Fly   335 ------------------LPTMTLPGYKLVK------RLDVSRN-------RLTNLSINHLPAKL 368
                              :.......:|.|:      :::|.:.       |...|.|:::....
Zfish   190 VHAEKAVIALSSTNVDIAIANDVFARFKEVEFTKVDGKMEVVQQMRSRALMRTVRLEISNVKTTW 254

  Fly   369 DYLDVSFNEIINMGNDVIKYLR----TVPIFKQTGNQWTIHC----------------DDKPLLN 413
            ::|..|.|.|:   :..|:.|.    |:...|...||.:.|.                |.|.|.:
Zfish   255 EFLTSSVNTIL---SSTIRELSLTDLTLTEMKDGANQSSTHILESFSTKRASVTTFIFDQKMLYD 316

  Fly   414 FFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKL 478
            ||.:            .|....||||.|..|:...|
Zfish   317 FFIN------------TPARKVSLTESPIIFMTCPG----------------------------- 340

  Fly   479 NNLNTIMSIYKYMEW------LHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILK---- 533
                   :|.|..|.      |..|:..||.|.:              |....:...|:|:
Zfish   341 -------TISKIQELDLSDCALTEKIFSVNPETE--------------CGTLVNLTRLVLRGNNL 384

  Fly   534 -----IDCRNKFVYNFPDIVARNSRLMGKQNMS----SPMELH--LSKNNISNITIAMLPKELRF 587
                 :..|...:.:...|....:.|...:|..    .|..||  ||:|....:....||..::.
Zfish   385 KHLSPLTSRINLMDSLQYIDLSQNTLTYSENQGRCFWPPRVLHVDLSRNGFDEVVFKCLPDSVQV 449

  Fly   588 LDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISP 652
            |:||.|.:.|:.                      .|..:...|.::        |:|..|....|
Zfish   450 LNLRHNRVSTVP----------------------ADIHTFDTLQVI--------DLTFNRLLDLP 484

  Fly   653 TDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLK 717
            |                     ||     ..|||...:    :|:|::       .|.:.. |||
Zfish   485 T---------------------CR-----SFPSLQKLL----IRSNSI-------HSPVPG-SLK 511

  Fly   718 L--HLLD-----NPWSCSC--NDIEKI---NFMKSVSSSIVDFTE-IKCSNGEKL---------- 759
            .  ||.|     ||:.|:|  .|...:   ..:|:..|::..:.: .:||..|..
Zfish   512 TCQHLQDLDLSHNPFICTCALRDFASLINAQGIKTFKSTLKHWPDGYRCSYPESWSNSTLEDFYL 576

  Fly   760 --VSINQHIVCPSDLFYYLALAISLVATIIALNFLI------WFRQPVLVWFYEHGVCLSLSAK- 815
              :|.|..|:.       :.:.|..::.|:|::.|.      |:.:  ::|.:......|::::
Zfish   577 PEISCNAWILA-------ITILIPTISLIVAVSLLCNRLDIPWYVR--MMWKWTRAKHYSITSQL 632

  Fly   816 RELDKDK-RFDAFLAFTHKDEALLE-EFVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDS 878
            :|.|.:: .|.||::::.|:...:: :|:.:|| |....::|.:.||::.|:::...|.:.|:.|
Zfish   633 KEEDVERLHFHAFVSYSQKNAGWVKSQFLPKLE-GDCGLRMCHHERDFIPGKTVVQNILRCIEQS 696

  Fly   879 RRIIVLMTENFMNSTWGRLEFRLALH-ATSRDRCKRLIVVLYP-NVKNFDSLDSELRTYMAFNTY 941
            ||.:.:::.:|:.|.|...|...|.| ..:|.....|:::|.| .:....|...:|:|.|:..||
Zfish   697 RRCVFVLSSHFVQSEWCHYELYFANHQKLTRGMDSILLILLEPLPLYLIPSKYYQLKTMMSRRTY 761

  Fly   942 LERSHPNFWNKLIYS 956
            ||........||.::
Zfish   762 LEWPQEGAKQKLFWA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	4/37 (11%)
		leucine-rich repeat	346..367	CDD:275378	5/33 (15%)
		leucine-rich repeat	563..583	CDD:275378	7/21 (33%)
		leucine-rich repeat	585..610	CDD:275378	5/24 (21%)
		leucine-rich repeat	611..622	CDD:275378	0/10 (0%)
		TIR	823..960	CDD:214587	37/137 (27%)
tlr1	NP_001124065.1	LRR_8	46..106	CDD:290566	19/76 (25%)
		leucine-rich repeat	48..71	CDD:275380	6/35 (17%)
		leucine-rich repeat	72..95	CDD:275380	8/26 (31%)
		leucine-rich repeat	109..145	CDD:275380	7/51 (14%)
		leucine-rich repeat	146..166	CDD:275380	2/19 (11%)
		leucine-rich repeat	346..373	CDD:275380	7/40 (18%)
		LRR_8	373..457	CDD:290566	18/83 (22%)
		leucine-rich repeat	374..399	CDD:275380	3/24 (13%)
		leucine-rich repeat	400..425	CDD:275380	4/24 (17%)
		leucine-rich repeat	426..446	CDD:275380	7/19 (37%)
		leucine-rich repeat	447..469	CDD:275380	6/43 (14%)
		LRR_8	469..526	CDD:290566	21/102 (21%)
		leucine-rich repeat	470..491	CDD:275380	8/54 (15%)
		leucine-rich repeat	492..515	CDD:275380	7/34 (21%)
		TPKR_C2	524..>565	CDD:301599	9/40 (23%)
		TIR	642..783	CDD:214587	37/136 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020