DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr3

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001013287.2	Gene:	tlr3 / 403126	ZFINID:	ZDB-GENE-040219-7	Length:	903	Species:	Danio rerio

Alignment Length:	1043	Identity:	192/1043 - (18%)
Similarity:	333/1043 - (31%)	Gaps:	417/1043 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AYDYIATNEYHLIMRDGHLEVNWKIPDPNIFIISPISKENRLKLNELIVSDTSYPIRA------- 90
            :|:.:|..|..|.:...||:. ..:....:::||..:.:|...|.:|.:||....::.
Zfish    84 SYNSLAGIEKDLCLSLPHLQF-LNVQHNQVYLISEKNLKNCFHLTQLDLSDNKLKLQGEPFSLLK 147

  Fly    91 ----VDYLR------QLGVE-------TVTRFENQINSFKVIERDVHYINGPKSLKIIIQSNLYL 138
                :|..|      :||.|       |:....|.||..:  |.|..:::...|.:::|.|:|.|
Zfish   148 NLTWLDVSRNKLTSAKLGTEPQLPNLVTLVLSGNNINILQ--ENDFSFLSNSSSFRVLILSSLIL 210

  Fly   139 NEIIEYINKTTDNVNEIIINAYKTV----------------------ENQQIALDNLIFNGKSHL 181
            .::.....|..|.::::::::.|..                      ..:|:.|.|..|.|....
Zfish   211 KKVENGCFKAIDTLSDLVLDSSKLTSQFTTSLFEELADTALRNLSLKSTEQVTLSNTTFQGLEKT 275

  Fly   182 RSLTFIGFQIENLSTK---------PFAQFINLKRMV---LTNCTVRNLTFLR--TLQKSL--EH 230
            : :|.:... ||..:|         |..:|::|:...   |||.:...|..||  .|:|:|  .|
Zfish   276 K-ITVLDLS-ENRISKIVDGAFQWLPQLEFLSLEHNTIRHLTNDSFSGLGNLRQLNLRKALIKSH 338

  Fly   231 LELDIDNE------VDLKYF----TNFSSLK---FMKVRNY--------------IPNKNFTALI 268
            ..|.:.::      |.|:|.    |.|..|.   |..:||.              :.||.|.
Zfish   339 ASLPVIDDFSFQHLVQLEYLCMANTAFRELTEQIFSGLRNLKTLDLSWSITGIKTVTNKTFA--- 400

  Fly   269 CTHKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGV-KLNFSNNSL 332
                         ||:...|.|.|          :.:.:|:.::.|....|.|.: .|..|.|.:
Zfish   401 -------------GLQESPLLQTL----------NLTGMGINKLEPGAFSSLGNLSNLLMSRNFI 442

  Fly   333 S-QLPTMTLPGYKLVKRLDVSRNR----LTNLSINHLP-------------------------AK 367
            : ||......|...:|.:|:|.|:    |||.|..|:.                         ..
Zfish   443 NQQLQGNEFKGLSNIKEIDMSINQQSISLTNASFVHVSTLRTLKLGRALKGTLDMEPSPFRPLVN 507

  Fly   368 LDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPM 432
            |..||:|.|.|.|:..|:::.|..:.:.|...|                :|..:.:|.:.....:
Zfish   508 LTILDLSNNNIANINADLLEGLYNLKVVKMQHN----------------NLARLWKMANPGGPVL 556

  Fly   433 FLHSLTEL--------------PKGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKL-NNLN 482
            ||...|.|              |..|..|...|.:.|           ...||..:|..: ::||
Zfish   557 FLKDATNLSYLNLDYNGIDEIPPNAFRGFSELHELSL-----------RGNLLDQLHASVFDDLN 610

  Fly   483 TIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPDI 547
            ::    ||
Zfish   611 SL----KY--------------------------------------------------------- 614

  Fly   548 VARNSRLMGKQNMSSPMELHLSKNNISNITIAM--LPKELRFLDLRFNNLVTLDDKVLSYLKKNS 610
                              |||.||.|:::..|.  :|                    ||.||
Zfish   615 ------------------LHLQKNLITSVQRATFGVP--------------------LSKLK--- 638

  Fly   611 IKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDC 675
             :..:..||::|.|:|           .|.:...|...|.|....|...:|...|..:
Zfish   639 -ELNMDHNPFDCTCES-----------ILWFSEWLNSTNTSVPGFPQSYICNTPNAYF------- 684

  Fly   676 RGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLDNPWSCSCNDIEKINFMKS 740

Zfish   685 ----------------------------------------------------------------- 684

  Fly   741 VSSSIVDFTEIKCSNGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYE 805
             :.|:::|..:.|.:           :.|....|  .|:.:.|..::.::||:.| |...:.||
Zfish   685 -NHSVMNFDPLSCKD-----------MTPFKALY--ILSSTAVLMLLFISFLVHF-QGWRIQFY- 733

  Fly   806 HGVCLSLSAKRELD--KDKR-------FDAFLAFTHKDEALLEEFVDRLERGRPRFQLCFY-LRD 860
                .::...|.|.  ||.:       |||::....:|::.:|..:..||.....|   || .||
Zfish   734 ----WNIMVNRMLGSLKDAKVTEGRFQFDAYIIHAGEDKSWVERSLLSLEDKDLNF---FYEQRD 791

  Fly   861 WLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRL--ALHATSRDRCKRLIVVLYPNVK 923
            ...|.|..:.|..::..||:||.::||..:...|.| :|:.  |||....|....||::...:|.
Zfish   792 STPGHSRLETIVDNMVYSRKIIFVITEMLLKDPWCR-QFKAHHALHHVMEDNRDSLILIFLEDVT 855

  Fly   924 NFD 926
            :::
Zfish   856 DYN 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	6/20 (30%)
		leucine-rich repeat	346..367	CDD:275378	9/49 (18%)
		leucine-rich repeat	563..583	CDD:275378	7/21 (33%)
		leucine-rich repeat	585..610	CDD:275378	4/24 (17%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	31/114 (27%)
tlr3	NP_001013287.2	LRR_RI	<49..183	CDD:238064	20/99 (20%)
		leucine-rich repeat	57..77	CDD:275380
		leucine-rich repeat	78..101	CDD:275380	4/16 (25%)
		leucine-rich repeat	102..125	CDD:275380	4/23 (17%)
		LRR_8	125..183	CDD:290566	11/57 (19%)
		leucine-rich repeat	126..148	CDD:275380	4/21 (19%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..276	CDD:275380	19/104 (18%)
		LRR_8	275..331	CDD:290566	13/57 (23%)
		leucine-rich repeat	278..300	CDD:275380	4/22 (18%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..354	CDD:275380	7/28 (25%)
		leucine-rich repeat	355..378	CDD:275380	6/22 (27%)
		leucine-rich repeat	379..404	CDD:275380	5/40 (13%)
		LRR_8	406..466	CDD:290566	16/69 (23%)
		leucine-rich repeat	408..431	CDD:275380	5/32 (16%)
		leucine-rich repeat	432..456	CDD:275380	6/23 (26%)
		leucine-rich repeat	457..507	CDD:275380	9/49 (18%)
		leucine-rich repeat	482..498	CDD:275380	0/15 (0%)
		leucine-rich repeat	508..531	CDD:275380	9/22 (41%)
		leucine-rich repeat	532..563	CDD:275380	6/46 (13%)
		LRR_8	562..622	CDD:290566	19/149 (13%)
		leucine-rich repeat	564..587	CDD:275380	4/22 (18%)
		leucine-rich repeat	588..611	CDD:275380	6/33 (18%)
		leucine-rich repeat	612..630	CDD:275380	9/96 (9%)
		LRRCT	645..>683	CDD:214507	12/48 (25%)
		TIR	756..898	CDD:214587	31/107 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920