DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and tlr21

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001186264.1	Gene:	tlr21 / 402884	ZFINID:	ZDB-GENE-040220-4	Length:	989	Species:	Danio rerio

Alignment Length:	996	Identity:	230/996 - (23%)
Similarity:	377/996 - (37%)	Gaps:	259/996 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 KVIERDVHYING---PKSLKIII-QSNLYLNEIIEYINKTT----DNVNEIIINAYKTVENQQIA 169
            |..|||:..|..   |.:|.:.| .||      |||:...:    .|:..:|::|     |....
Zfish    45 KSYERDITAIVSDVFPTALNLTISHSN------IEYVQSQSFDHLPNLTALILDA-----NHITN 98

  Fly   170 LDNLIFNGKSHLRSLTFIGFQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTLQKSLEHLELD 234
            :|...||...||::|......|..|....|:...||.:::|.:..:.|
Zfish    99 IDKDAFNNLHHLQTLNLSCNNISFLHRDVFSDLHNLTQLLLGSNKLTN----------------- 146

  Fly   235 IDNEVDLKYFTNFSSLKFMKV-RNYIPN--------KNFTALICTHKNCNFIRGI-NGLECPKLC 289
                .|...|::.::||.:.: ||::.|        .|.|:||....:.|.:..: :....|:..
Zfish   147 ----PDKYLFSSLTNLKILDLRRNHLYNFSSVVESITNLTSLIKLDLSFNKLTTLQHSTHLPESL 207

  Fly   290 QCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRN 354
            ..||:.|:....:.|....|:.:.          ||:.|:|  ..|.:.:..|.|| :.:...|.
Zfish   208 ALLYLGDNKLKTLGCDKSFLMNVK----------KLDLSDN--KNLASKSFLGLKL-ENITYLRL 259

  Fly   355 RLTNLSI-------NHLPAKLDYLDVSFNE-------IINMGNDVIKYLRTVPIFKQTGNQWTIH 405
            |.||:||       |..|..:|:..:....       .:.|.|...|:|:...:..|:.:...:.
Zfish   260 RFTNISIFKLLTYPNVHPWHIDFSGLKLKNSHALSSLCVLMRNHSHKHLQIPKMLLQSNSIGALK 324

  Fly   406 CDDKPLLNFFRHLKLIIR---MKSAEMKP----MFLHSLTELPKGFLKFLGKHFIWL-GVRKQEY 462
                  .|.||:...|.|   :...|:|.    .|||:.|:|..  ||....|...| ...|.|
Zfish   325 ------NNTFRYCPSITREMDLSRNELKSAGCLQFLHNQTQLKS--LKMEHNHLTKLTSCNKAE- 380

  Fly   463 YLINEEQLLQSMHRKLNNL----NTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCEC 523
                       :|..|.||    |.|:.|..|......||..:  |.::..|..|    .||. .
Zfish   381 -----------IHNSLTNLSYRYNRILQISGYAFSNTPKLEIL--ELNINIIAYM----DHKA-L 427

  Fly   524 CYSRDSLILKIDCRNKF---VYN--FPDIVARNSRLMGKQNMSSPMELHLSKNNIS---NITIAM 580
            ...:|...|::|  |..   :||  |.|:.          |:.:   |:|..|.|:   |.|...
Zfish   428 SGLKDLKTLRLD--NNLLSDIYNDSFEDLT----------NLKT---LNLRNNEIAVIFNYTFQN 477

  Fly   581 LPKELRFLDLRFNNLVTLD----DKVLS----YLKKNSIKT-------KLSGNPWNCDCKSRSVL 630
            |.| |..|||..|.:..|.    |.:.|    ||.:|.:|.       ||||.....|.:...::
Zfish   478 LSK-LDILDLGGNKISQLKPHAFDGLYSLTNLYLDRNHLKMIDVVLFGKLSGTLQVLDLQGNMIM 541

  Fly   631 SIL-RDHEPLE-----YDVTL-----KRCNISP----------------------------TDCP 656
            ... ..|.|.:     ||:.|     ...|:.|                            .|..
Zfish   542 YFTEHTHSPFKNMSRLYDLKLNGQQPNGINLLPRAFFRGLTSLKSLYLTNNHIIGFGDETFDDLK 606

  Fly   657 DVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSS--RVTYVDLRN-----------NNLTALSQKNR 708
            ::....|||        .|.|...||.....|  ::..:.|.|           .|||.|...:.
Zfish   607 NLDYLTLDN--------SCAGVAQLQSGIFKSLQKLRTLSLENMGIKSFSKDVFGNLTGLKTLHL 663

  Fly   709 SSIENRSLKLHLLDN------------PWSCSCNDIEKINFMKSVSSSIVDFT---EIKCSN--G 756
            :.....||.:.||||            |.||.|::.:..|:  ::.:..:.|.   .|.|.:  |
Zfish   664 NRNPMMSLDISLLDNLTNLIYIDMRSCPLSCGCHNSDLQNW--TIMNKRLQFPHLFNITCPDHPG 726

  Fly   757 EKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYEHGVCLSLS-------A 814
            ....:.:.. ||..|:..|...:.|.:..::.|..|::.:   |.|.:::|..:..|       .
Zfish   727 SYFHNFDTK-VCYLDIELYFFSSTSTLTILLTLIPLLYVK---LYWKFKYGYYVFRSWFGEQWRR 787

  Fly   815 KRELDKDKRFDAFLAFTHKDEA-LLEEFVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDS 878
            .|:.::...:|||:::...||. ::|:.:..||..  .|:||.:.||:..|..|.|.|..::..|
Zfish   788 LRDQEEKYNYDAFVSYNSADEDWVMEQLLPNLEGS--SFRLCLHHRDFELGRDIVDNIVAAVYGS 850

  Fly   879 RRIIVLMTENFMNSTWGRLEFRLALHATSRD-RCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYL 942
            |:.|.:::::|:.|.|..||.:||.:...:: :...|:|.|.|..:...|....:|..|...|||
Zfish   851 RKTICVVSQSFLRSEWCSLEIQLASYRLFQEMQDVLLLVFLEPIPERQLSAYHRMRKVMLKKTYL 915

  Fly   943 E-----RSHPN-----FWNKL 953
            :     .|.||     |||:|
Zfish   916 QWPGSNCSDPNSAKELFWNQL 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	5/19 (26%)
		leucine-rich repeat	346..367	CDD:275378	8/27 (30%)
		leucine-rich repeat	563..583	CDD:275378	7/22 (32%)
		leucine-rich repeat	585..610	CDD:275378	10/32 (31%)
		leucine-rich repeat	611..622	CDD:275378	5/17 (29%)
		TIR	823..960	CDD:214587	44/143 (31%)
tlr21	NP_001186264.1	leucine-rich repeat	65..85	CDD:275380	6/25 (24%)
		LRR_8	84..144	CDD:290566	16/64 (25%)
		leucine-rich repeat	86..109	CDD:275380	6/27 (22%)
		LRR_RI	107..350	CDD:238064	57/282 (20%)
		leucine-rich repeat	110..133	CDD:275380	5/22 (23%)
		leucine-rich repeat	134..157	CDD:275380	5/43 (12%)
		LRR_8	156..217	CDD:290566	14/60 (23%)
		leucine-rich repeat	158..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..206	CDD:275380	4/21 (19%)
		leucine-rich repeat	207..229	CDD:275380	5/21 (24%)
		leucine-rich repeat	230..253	CDD:275380	8/35 (23%)
		LRR_RI	<336..540	CDD:238064	63/240 (26%)
		leucine-rich repeat	360..383	CDD:275380	7/36 (19%)
		leucine-rich repeat	385..408	CDD:275380	7/22 (32%)
		LRR_8	407..467	CDD:290566	19/81 (23%)
		leucine-rich repeat	409..432	CDD:275380	6/29 (21%)
		leucine-rich repeat	433..456	CDD:275380	7/34 (21%)
		LRR_8	455..515	CDD:290566	20/73 (27%)
		leucine-rich repeat	457..480	CDD:275380	7/25 (28%)
		leucine-rich repeat	481..504	CDD:275380	7/22 (32%)
		leucine-rich repeat	505..529	CDD:275380	7/23 (30%)
		leucine-rich repeat	530..556	CDD:275380	3/25 (12%)
		LRR_8	555..615	CDD:290566	7/59 (12%)
		leucine-rich repeat	557..583	CDD:275380	5/25 (20%)
		LRR_8	582..668	CDD:290566	15/93 (16%)
		leucine-rich repeat	584..607	CDD:275380	1/22 (5%)
		leucine-rich repeat	608..633	CDD:275380	8/32 (25%)
		leucine-rich repeat	634..657	CDD:275380	4/22 (18%)
		leucine-rich repeat	658..679	CDD:275380	6/20 (30%)
		leucine-rich repeat	682..694	CDD:275378	1/11 (9%)
		TIR	797..942	CDD:214587	44/142 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920