DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and Tlr3

DIOPT Version :10

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:1004 Identity:207/1004 - (20%)
Similarity:359/1004 - (35%) Gaps:310/1004 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 DPNIFIISPISKENRLKLNELI-VSDTSYPIRAVDYLRQLGVETVTRFENQINSFKVIERDVHYI 122
            :|.:..|.|:.|...|:.|||. :||.::..          ...:|......||.:.|:.     
  Rat    92 EPELCQILPLLKVLNLQHNELSQISDQTFAF----------CTNLTELHLMSNSIRKIKS----- 141

  Fly   123 NGPKSLKIIIQSNLYLNEIIEYINKT---TDNVNEIIINAYKTVENQQIAL--DNLIFNGKSHLR 182
            |..|:.|.:|:.:|..|.:......|   .:|:.|:::     .:|:..||  :.|.|.|.|.|:
  Rat   142 NPFKNQKSLIKLDLSRNGLSSTKLGTGVQLENLQELLL-----AKNKIFALRSEELDFLGNSSLQ 201

  Fly   183 SLTFIGFQIENLSTKPFAQF----------------------INLKRMV---LTNCTVRNL---- 218
            .|        :||:.|..:|                      :||...:   |:|.:::||    
  Rat   202 KL--------DLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTEKLCWELSNTSIQNLSLAN 258

  Fly   219 ---------TFLRTLQKSLEHLELDIDNEVDLKYFTN----------FSSLKFMKVRNYIPNKNF 264
                     ||....|.:|..|:|..::   |:|..|          :.||::..:::..|:.  
  Rat   259 NQLLATSNSTFSGLKQTNLTSLDLSYNS---LRYVGNDAFSWLPHLKYLSLEYNNIQSLTPHS-- 318

  Fly   265 TALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVK----L 325
                        .||::.|.        |:  .|:......::.|...|.:...|:..:|    |
  Rat   319 ------------FRGLSNLR--------YL--SLKRAFTKQSVALASHPNIDDFSFQWLKCLEHL 361

  Fly   326 NFSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHLPAKLDYLDVS--FNEIINMGNDVIKY 388
            |..:|        |:||.|        .|..|.|      ..|.||.:|  |..:..:.|:....
  Rat   362 NMDDN--------TIPGIK--------SNTFTGL------VSLKYLSLSKTFTGLQTLTNETFVS 404

  Fly   389 LRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGK-HF 452
            |...|:.               .||..:                  :.::::..|...:||: ..
  Rat   405 LTHSPLL---------------TLNLTK------------------NHISKIASGTFSWLGQLRI 436

  Fly   453 IWLGVRKQEYYLINEEQLLQSMHRKLNNLNTI-MSIYKYMEWLHRKLIFVNREYDLFYIRQMA-- 514
            :.||:.:.|..|..:|      .|.|.|:..| :|..||::...:....|.....|. :|::|  
  Rat   437 LDLGLNEIEQELTGQE------WRGLGNIFEIYLSYNKYLQLTSKSFTLVPSLQRLM-LRRVALK 494

  Fly   515 ----APCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISN 575
                :|.|.:.                   :||.                   ..|.||.|||:|
  Rat   495 SVDISPSPFRP-------------------LYNL-------------------TILDLSNNNIAN 521

  Fly   576 ITIAMLP--KELRFLDLRFNNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILR---- 634
            :...:|.  :.|..||.:.|||..|            .|....|.|.|. .|..|.|.||.    
  Rat   522 LNEDLLEGLENLEILDFQHNNLARL------------WKHANPGGPVNF-LKGLSHLHILNLESN 573

  Fly   635 --DHEPLEYD---VTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVD 694
              |..|::..   ..||..|:.           |:||.             ..:||:....|  .
  Rat   574 GLDEIPVKVFKNLFELKSINLG-----------LNNLN-------------TLLPSIFDDQT--S 612

  Fly   695 LRNNNLTALSQKNRSSIENRSL------KLHLLD---NPWSCSCNDIE-KINFMKSVSSSIVDF- 748
            ||:.||    |||..:...:|:      .|:.||   ||:.|:|..|. .:.::....::|.:. 
  Rat   613 LRSLNL----QKNLITSVEKSVFGPAFHNLNSLDMSFNPFDCTCESIAWFVTWLNQTHTNIPELS 673

  Fly   749 TEIKCSNGEKL----VSINQHIVCPSDLFYYLALAI--SLVATIIALNFLIWFRQPVLVWFYEHG 807
            |...|:..::.    |.:.....|.....:.|...|  |.:.|.|....||.|....:.:::...
  Rat   674 THYLCNTPQRYHGLPVKLFDTSSCKDSAPFQLLFIINTSTLLTFILAVLLIHFEGWRISFYWNVS 738

  Fly   808 VCLSLSAKRELD-KDKRFD--AFLAFTHKDEALLEEFVDRLERGRPRFQLCFYLRDWLAGESIPD 869
            |...|..| |:| :.::|:  |::....||...:.|....:|......:.|...||:.||....:
  Rat   739 VHRILGFK-EIDAQGEQFEYTAYIIHAQKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLE 802

  Fly   870 CIGQSIKDSRRIIVLMTENFMNSTWGRLEFRL--ALHATSRDRCKRLIVVLYPNVKNFDSLDSEL 932
            .|..|||.||:||.::|.:.:.....| .|::  |:..........:|::...|:.:: .|:..|
  Rat   803 AIVNSIKRSRKIIFVITHHLLKDPLCR-RFKVHHAVQQAIEQNLDSIILIFLQNIPDY-KLNHAL 865

  Fly   933 -------RTYMAFNTYLERSHPN-FWNKL 953
                   :::...|..:::...| |.:||
  Rat   866 CLRRGMFKSHCILNWPIQKERINAFHHKL 894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 PRK15370 <315..>398 CDD:185268 20/88 (23%)
leucine-rich repeat 325..345 CDD:275378 6/19 (32%)
leucine-rich repeat 346..367 CDD:275378 3/20 (15%)
TIR 823..960 CDD:214587 32/143 (22%)
Tlr3NP_942086.2 leucine-rich repeat 37..53 CDD:275380
leucine-rich repeat 54..77 CDD:275380
PLN00113 66..>646 CDD:215061 152/751 (20%)
leucine-rich repeat 78..101 CDD:275380 2/8 (25%)
leucine-rich repeat 102..125 CDD:275380 7/32 (22%)
leucine-rich repeat 126..149 CDD:275380 6/27 (22%)
leucine-rich repeat 150..199 CDD:275380 12/53 (23%)
leucine-rich repeat 200..250 CDD:275380 10/57 (18%)
leucine-rich repeat 251..276 CDD:275380 5/24 (21%)
leucine-rich repeat 277..300 CDD:275380 6/25 (24%)
leucine-rich repeat 301..322 CDD:275380 4/34 (12%)
leucine-rich repeat 325..381 CDD:275380 17/87 (20%)
leucine-rich repeat 382..407 CDD:275380 7/24 (29%)
leucine-rich repeat 410..433 CDD:275380 4/55 (7%)
leucine-rich repeat 434..458 CDD:275380 7/29 (24%)
leucine-rich repeat 459..482 CDD:275380 5/22 (23%)
leucine-rich repeat 483..508 CDD:275380 5/44 (11%)
leucine-rich repeat 509..532 CDD:275380 8/41 (20%)
leucine-rich repeat 533..564 CDD:275380 12/43 (28%)
leucine-rich repeat 565..586 CDD:275380 5/20 (25%)
leucine-rich repeat 589..612 CDD:275380 9/48 (19%)
leucine-rich repeat 613..631 CDD:275380 8/21 (38%)
LRRCT 646..698 CDD:214507 9/51 (18%)
Tlr3_TMD 699..731 CDD:465595 8/31 (26%)
TIR 756..901 CDD:214587 31/141 (22%)
Blue background indicates that the domain is not in the aligned region.

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