DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and Tlr12

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001102152.1	Gene:	Tlr12 / 362604	RGDID:	1559145	Length:	904	Species:	Rattus norvegicus

Alignment Length:	911	Identity:	194/911 - (21%)
Similarity:	324/911 - (35%)	Gaps:	275/911 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 GKSHLRSLTFI----GFQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTLQKSLEHL------ 231
            |...||:|:|:    |.....|....|...|:|:|:......:.....:| |..||:.|
  Rat   113 GLGQLRNLSFVDQPSGKNSLFLPPDAFGDLISLQRLHFCGPCLNKKAGVR-LPSSLQWLSVTISC 176

  Fly   232 ---------------------------ELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALIC 269
                                       :||:.....||..|. .||:.::|       ....|..
  Rat   177 LQDSGELAGIFPDLVQNSSSRASWTLKKLDLSLNQKLKMATP-GSLQGLQV-------EILDLRK 233

  Fly   270 THKNCNFIRGINGLECPKLCQCLYIID-------------DLE-LNIDCSNLGLLQIPPLPIPSY 320
            |..:...::|: ||:  || ..||...             :|: ||:|.|.:|  .|....:.|.
  Rat   234 TQLDAGAVKGL-GLQ--KL-NVLYAPTATAELAAETAAHFELQGLNVDRSKIG--NISQEALASC 292

  Fly   321 GGVK-LNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRL--TNLSINHL--PAKLDYLDVSFN---- 376
            ..:: |:.|:..|::||...|.....::||:::.|:|  |.|.:|..  .:.|..||:|.|
  Rat   293 HSLETLSLSDTGLTKLPPGFLAAMPRLRRLNLAGNQLQSTMLCMNETGDVSGLSTLDLSGNGLRI 357

  Fly   377 -------------EIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRH-LKLIIRMKSA 427
                         |::...|.::. |...| |:......|:..|..||||..:: |..:..:.:.
  Rat   358 LPPATFSCLPHLRELLLQDNQLLS-LEGHP-FQDLQQLETLKLDRNPLLNLGKNCLAALPALTTL 420

  Fly   428 E-MKPMFLHSLTELP-KGFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLN--TIMSIY 488
            . :....|||    | .||         | |.|.           |.::|..|..|:  .::|:.
  Rat   421 SLLDTQILHS----PDAGF---------W-GARS-----------LHTLHLSLPPLSAPAVLSLP 460

  Fly   489 KYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSR 553
            .|:..|...:....:.:.|         .|:                     ::.|.:.:..|.|
  Rat   461 MYLTSLELHVTPGLKHWTL---------SPN---------------------IFPFLETLTINGR 495

  Fly   554 --LMGKQNMS----SPMELHLSKNNI--------SNITIAMLPKELRFLDLRFNNLVTLDDKVLS 604
              .:|.||.|    :...|.|.:|::        |:|.:..|||                   |.
  Rat   496 GLKLGVQNASEVFPALQHLFLLQNSLDAFCSQDASSIFLWQLPK-------------------LQ 541

  Fly   605 YLK-----KNSIKTKLSGNPWNCDCKSRSVLSILRDH----EPLEYDV-TLKRCNISPTDCPDVC 659
            .||     .||....::|.|...:.|..|:.||.:..    |.|..|: .|:...:|.|
  Rat   542 SLKVWGAGSNSRPCLITGLPSLQELKLESLQSITQPRSVQLEELVGDLPQLQALQLSST------ 600

  Fly   660 VCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTAL---SQKN---RSSIENRSLKL 718
                               ||..:.:.:.|      |.::|.||   |:|:   :.|:...|.::
  Rat   601 -------------------GLKSLSAAAFR------RLHSLQALVLDSEKDLVLQDSLREYSPQM 640

  Fly   719 ----HLLDNPWSCSCNDIEKINFMKSVSSSIVDFTEIKCSNGEKLVSINQHIV------CPSDLF 773
                ::|.:..:|.|.:.....::|..:.:.|...:.....||..|.....::      ||..|.
  Rat   641 PRYVYILQSKLACQCANAWMELWVKQSTKTYVHIRDGHLCPGEVRVPARDSLISFLWDHCPQTLE 705

  Fly   774 YYLALAIS-LVATIIALNFL-----IWFRQPVL-----VWFYEHGVCLSLSAKRELDKDKRFDAF 827
            ..|.||.| ||..:|.|..|     .|.  |.|     :|..      .|..:....|...||.|
  Rat   706 LKLFLASSALVLLLIVLPLLQGARNTWI--PYLRALFRIWLQ------GLRGQGNAGKRFLFDVF 762

  Fly   828 LAFTHKDEA-LLEEFVDRLERGRPR---FQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTEN 888
            ::...:|:. :|||.:..||...|.   .:||...||:..|:.:.|.:..|:..||..:.:::..
  Rat   763 VSHCRQDQGWVLEELLPALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMVSSRVTLCVLSGP 827

  Fly   889 FMNSTWGRLEFRLA----LHATSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYLERSHPNF 949
            .:.:....||.|||    |.|.|..  ..|:|.|.|..::      :|.:|......|.|.....
  Rat   828 ALCNPRCCLELRLATSLLLAAPSPP--VLLLVFLEPISRH------QLPSYHRLARLLRRGDYCL 884

  Fly   950 W 950
            |
  Rat   885 W 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	6/19 (32%)
		leucine-rich repeat	346..367	CDD:275378	7/24 (29%)
		leucine-rich repeat	563..583	CDD:275378	6/27 (22%)
		leucine-rich repeat	585..610	CDD:275378	3/29 (10%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	36/136 (26%)
Tlr12	NP_001102152.1	leucine-rich repeat	71..93	CDD:275380
		leucine-rich repeat	94..116	CDD:275380	1/2 (50%)
		leucine-rich repeat	117..144	CDD:275380	7/26 (27%)
		leucine-rich repeat	202..225	CDD:275380	7/23 (30%)
		leucine-rich repeat	226..270	CDD:275380	10/54 (19%)
		leucine-rich repeat	246..259	CDD:275381	5/15 (33%)
		LRR_8	270..329	CDD:290566	17/60 (28%)
		leucine-rich repeat	271..294	CDD:275380	8/24 (33%)
		LRR_4	294..331	CDD:289563	10/36 (28%)
		leucine-rich repeat	295..318	CDD:275380	6/22 (27%)
		leucine-rich repeat	319..344	CDD:275380	7/24 (29%)
		LRR_8	343..403	CDD:290566	12/61 (20%)
		LRR_RI	345..547	CDD:238064	53/277 (19%)
		leucine-rich repeat	345..368	CDD:275380	5/22 (23%)
		leucine-rich repeat	369..392	CDD:275380	5/24 (21%)
		leucine-rich repeat	393..416	CDD:275380	7/22 (32%)
		leucine-rich repeat	417..437	CDD:275380	7/33 (21%)
		leucine-rich repeat	441..510	CDD:275380	16/98 (16%)
		leucine-rich repeat	511..562	CDD:275380	14/69 (20%)
		leucine-rich repeat	563..591	CDD:275380	7/27 (26%)
		leucine-rich repeat	592..615	CDD:275380	7/53 (13%)
		TIR	759..900	CDD:214587	36/135 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020