DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and CG18095

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	142/676 - (21%)
Similarity:	230/676 - (34%)	Gaps:	268/676 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 KRMVLTNCTVRNLTFLRTLQKSLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICT 270
            |..:||:.|:.|.|        |.|:|..        :|..|..|..:::::
  Fly    37 KTELLTSLTLSNCT--------LPHVENG--------FFVRFDHLLHLELQH------------- 72

  Fly   271 HKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQL 335
                   .|::.|            ||..||      ||.::      .|    |:.|:|:||.|
  Fly    73 -------SGLSDL------------DDFSLN------GLTKL------QY----LSLSHNNLSSL 102

  Fly   336 PTMTLPGYKLVKRLDVSRNRLTNLSINHLP--AKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQT 398
            .:.:......:..||:|.|.|:.||:....  .:|..||:.:|.|..:.||....|..:......
  Fly   103 RSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLN 167

  Fly   399 GNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQEYY 463
            ||| ..|.|.    :|||.                ||.|:.               |.::.....
  Fly   168 GNQ-LAHIDG----SFFRG----------------LHRLSS---------------LSLQHNRIE 196

  Fly   464 LINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHR----KLIFVNREYDLFYIRQMAAPCPHKCECC 524
            .|..:....:.|  |.:|....::...:::|.:    :|:.:|..
  Fly   197 FIEMDSFESNTH--LRSLRLDQNLLSSLQFLSQRGLARLVHLNLS-------------------- 239

  Fly   525 YSRDSLILKIDCRNKFVY--NFP----DIVARNSRLMGKQNMS---SPMELHLSKNNISNI---- 576
               .:|:.|::   .||:  ||.    |:...|...:.|:.:|   |...|::|.|.:..|
  Fly   240 ---SNLLQKLE---PFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDES 298

  Fly   577 ---TIAMLPKELRFLDLRFNNLVTLDDKVLSY--------LKKNSIKTKLSGNPWNCDCKSRSVL 630
               .||:|.     ||:.||.|.||.|.:..:        |..|.|:...|...:|
  Fly   299 LDSLIALLQ-----LDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFN--------- 349

  Fly   631 SILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDL 695
               ::|        |:...:|.....|...  ||.|:                ||::....||||
  Fly   350 ---QNH--------LRYIKLSGNAISDAAF--LDRLS----------------PSVNRFTLYVDL 385

  Fly   696 RNNNLTALSQKNRSSIENRSLKLH-----LLDNPWSCS---CNDIEK----INF------MKSVS 742
            .:|.|.:|   |.||:      ||     |.||.|||:   .|.::|    :||      :.::|
  Fly   386 SSNRLKSL---NLSSL------LHFRYINLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNLS 441

  Fly   743 SSIVDFTEIKCSNGEKLVSINQHIV----------------C-------------------PSDL 772
            .:..:...|.|..|    ..|:.|:                |                   |:|.
  Fly   442 ENTTNVEGIDCIEG----GTNRSIILLDVSGVPQPKSDNCDCVVAYDETNPSPPPLTWPKIPTDR 502

  Fly   773 FYYLALAI-SLVATIIALNFLIWFRQ 797
            |...::.| .|||..||.:.|.|.|:
  Fly   503 FDSRSVIIWMLVAIAIAFSGLRWLRR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	6/19 (32%)
		leucine-rich repeat	346..367	CDD:275378	7/22 (32%)
		leucine-rich repeat	563..583	CDD:275378	7/26 (27%)
		leucine-rich repeat	585..610	CDD:275378	9/32 (28%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	10/38 (26%)
		LRR_8	64..123	CDD:290566	20/106 (19%)
		leucine-rich repeat	65..88	CDD:275380	9/60 (15%)
		leucine-rich repeat	89..112	CDD:275380	7/32 (22%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	115..384	CDD:238064	75/375 (20%)
		LRR_8	135..195	CDD:290566	20/95 (21%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	9/43 (21%)
		LRR_8	184..243	CDD:290566	9/98 (9%)
		leucine-rich repeat	185..208	CDD:275380	3/37 (8%)
		leucine-rich repeat	209..232	CDD:275380	3/22 (14%)
		LRR_8	232..289	CDD:290566	15/82 (18%)
		leucine-rich repeat	233..256	CDD:275380	7/48 (15%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		LRR_8	280..339	CDD:290566	18/63 (29%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..328	CDD:275380	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930