DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and Toll-4

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	1052	Identity:	406/1052 - (38%)
Similarity:	612/1052 - (58%)	Gaps:	130/1052 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IPDDYCETYCGGICNDTVASKTCDREAYDYIATNEYHLIMRDGHLEVNWKIP------------- 58
            |.:||||.|    .::...:.||. .|.:.:.|.:|.:.:....||:||..|
  Fly    88 IREDYCEIY----LDELGENGTCS-IANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNE 147

  Fly    59 -DPNIFIISPISKENRLKLNELIVSDTSYPIRAVDYLRQLGVETVTRFENQINSFKVIERDVHYI 122
             |..:.|||.:...:.:   ::.:|.      ||.||..||:..::.::..:.|..:.|.|||:.
  Fly   148 TDYELVIISVLGIRSEV---DMRISP------AVQYLSLLGIREISGYDIYLPSVLITEMDVHHA 203

  Fly   123 NGPK--SLKIIIQSNLYLNEII--EYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRS 183
            ||||  :.|.:..|.  :|.:|  .||.||.:|..:|.|..:.|.|...:.::..||:||:.:.:
  Fly   204 NGPKMVTFKYLYDST--VNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSA 266

  Fly   184 LTFIGFQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLR--TLQKSLEHLELDIDNEVDLKYFTN 246
            |.|.|.:|:.|:...|....:|..::..|..:::|:|||  |||.||.:..:.:||.||||.|..
  Fly   267 LIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEK 331

  Fly   247 FSSLKFMKVRNYIPNKNFTALICT--HKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGL 309
            |::|:.::|..|...|||||.||.  ..:|.|..|||.:.||..|.|.|..|..:|.|||....|
  Fly   332 FTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNL 396

  Fly   310 LQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHLPAKLDYLDVS 374
            ..||.||:|..|...|.|.:|.|::||..:|.||..:|.||||.|:||:||::.||..|.|||:.
  Fly   397 TTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIR 461

  Fly   375 FNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTE 439
            .|:|..:...|::||.:|.:|.|.||:|:|:||:..|..||.:...::|:|:::.:.:.  ...|
  Fly   462 HNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIM--EYIE 524

  Fly   440 L-PKGFLKFLGKHFIWLGVRKQEYYL-INEEQLLQSM--HRKLNNLNTIMSIYKYMEWLHRKLIF 500
            | .||  .|:...|:   ....:.|| .||::::.:.  ..|..||       |.||.|:..:..
  Fly   525 LSSKG--SFVENFFV---QNIDQLYLEANEDEIIDAFGPSDKYFNL-------KLMEALNHAIWL 577

  Fly   501 VNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPDI-----------VARNS-- 552
            .:.|:|...:..:.:|||::|.||:...:....|:|||..:..:|.:           :.||.
  Fly   578 FSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIR 642

  Fly   553 RLMGKQNM-----SSPMELHLSKNNISNITIAMLPKELRFLDLRFNNLVTLDDKVLSYL--KKNS 610
            :|...:::     :|..:||:|:|.:..:.:.:||:.:.:||:|.|.|..|||.|:::|  ::|.
  Fly   643 KLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENI 707

  Fly   611 IKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLD--NLTWPSFIV 673
            .|.:||||||.|:||:::.||.||.|||:||:..|:|..|:...||:.|:||:|  |....:::|
  Fly   708 TKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVV 772

  Fly   674 DCRGEGLLQMPSLSS-----------------------------------------------RVT 691
            ||.|:.|.::|.|.:                                               ::.
  Fly   773 DCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLE 837

  Fly   692 YVDLRNNNLTALSQKNRSSIENR----SLKLHLLDNPWSCSCNDIEKINFMKSVSSSIVDFTEIK 752
            |:|:.|||.:||..:.|..::.|    .|:|.|..|||:|.|.|.:.:.|:|..:.:|.:.:.|:
  Fly   838 YLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQ 902

  Fly   753 C-SNGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYEHGVCLSLSAKR 816
            | ..|..|:.:.:..:|||.|.||.:||:||:...:::|..|.||||:::|||||.:||||:|:|
  Fly   903 CIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARR 967

  Fly   817 ELDKDKRFDAFLAFTHKDEALLEEFVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRI 881
            |||:||::||||:||||||.|:||||||||.||.:|:|||||||||.||||||||.||:|.||||
  Fly   968 ELDEDKKYDAFLSFTHKDEDLIEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRI 1032

  Fly   882 IVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYLERSH 946
            |:|||:||:.|||||||||||||||||||||||||||||:|::||.||||||.||..||||:|::
  Fly  1033 IILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNN 1097

  Fly   947 PNFWNKLIYSMP 958
            |||||||:||||
  Fly  1098 PNFWNKLMYSMP 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	9/19 (47%)
		leucine-rich repeat	346..367	CDD:275378	12/20 (60%)
		leucine-rich repeat	563..583	CDD:275378	5/19 (26%)
		leucine-rich repeat	585..610	CDD:275378	10/26 (38%)
		leucine-rich repeat	611..622	CDD:275378	7/10 (70%)
		TIR	823..960	CDD:214587	108/136 (79%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..308	CDD:275380	6/19 (32%)
		leucine-rich repeat	309..334	CDD:275380	12/24 (50%)
		leucine-rich repeat	335..386	CDD:275380	21/50 (42%)
		leucine-rich repeat	388..408	CDD:275380	9/19 (47%)
		LRR_8	412..465	CDD:290566	26/52 (50%)
		leucine-rich repeat	412..432	CDD:275378	9/19 (47%)
		LRR_4	432..470	CDD:289563	18/37 (49%)
		leucine-rich repeat	433..454	CDD:275378	12/20 (60%)
		leucine-rich repeat	455..478	CDD:275378	9/22 (41%)
		leucine-rich repeat	479..490	CDD:275378	5/10 (50%)
		leucine-rich repeat	632..657	CDD:275378	3/24 (13%)
		leucine-rich repeat	658..679	CDD:275378	6/20 (30%)
		leucine-rich repeat	680..706	CDD:275378	10/25 (40%)
		leucine-rich repeat	707..719	CDD:275378	7/11 (64%)
		leucine-rich repeat	771..791	CDD:275380	7/19 (37%)
		leucine-rich repeat	793..815	CDD:275378	0/21 (0%)
		leucine-rich repeat	816..835	CDD:275378	0/18 (0%)
		leucine-rich repeat	836..859	CDD:275378	8/22 (36%)
		TIR	974..1110	CDD:214587	108/136 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920