DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and Tlr9

DIOPT Version :9

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_937764.1 Gene:Tlr9 / 338457 RGDID:631352 Length:1032 Species:Rattus norvegicus


Alignment Length:1081 Identity:225/1081 - (20%)
Similarity:389/1081 - (35%) Gaps:323/1081 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 IATNEYHLIMRD-------GHLEVNWKIPDPNIFIISPISKENRLKLNELIVSDTSYPIRAVDYL 94
            ||...:||...|       ..|.:.|..|.|.   :||:....|:    .|...|...:|.::.|
  Rat    71 IANRIHHLHNLDFVHLPNVRQLNLKWNCPPPG---LSPLHFSCRM----TIEPKTFLAMRMLEEL 128

  Fly    95 R--QLGVETVTRFENQINSF-----KVIERDVHYINGPKSLKIIIQSN--LYLNEIIEYINKTTD 150
            .  ..|:.||.|..:.:.:.     .::..|...:.|..||:::....  .|.|.....:|.|.|
  Rat   129 NLSYNGITTVPRLPSSLTNLSLSHTNILVLDASSLAGLHSLRVLFMDGNCYYKNPCNGAVNVTPD 193

  Fly   151 ----------------NVNEI----------IINAYKTV-------------------------- 163
                            |:.|:          ::.:|..:                          
  Rat   194 AFLGLSNLTHLSLKYNNLTEVPRQLPPSLEYLLLSYNLIVKLGPEDLANLTSLRVLDVGGNCRRC 258

  Fly   164 --------ENQQIALD--NLIFNGKSHLRSLTFIGFQIENLSTKPFAQFINLKRMVLT------- 211
                    |.:|.:||  ...|:..|||..|......:.:|::|.|...:||..:.|:       
  Rat   259 DHAPDLCTECRQKSLDLHPQTFHHLSHLEGLVLKDSSLHSLNSKWFQGLVNLSVLDLSENFLYES 323

  Fly   212 ---NCTVRNLTFLRTLQKSLEHLELDIDNEVD---LKYFTNFSSLKFMKVRNYIPNKNFTALICT 270
               ....:|||.||.|..|..:.:     :|.   |...::|.||..::..|.  |..|..|:  
  Rat   324 INKTSAFQNLTRLRKLDLSFNYCK-----KVSFARLHLASSFKSLVSLQELNM--NGIFFRLL-- 379

  Fly   271 HKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVK-LNFSNNSLSQ 334
              |.|.:|.:.||  |||       ..|.|.::..|...|.:    ..::..:: ::.|||.:|.
  Rat   380 --NKNTLRWLAGL--PKL-------HTLHLQMNFINQAQLSV----FSTFRALRFVDLSNNRISG 429

  Fly   335 LPTMT-----------------------LPGYKLVKR-----------LDVSRNRLTNL------ 359
            .||::                       ||...:.|.           :|:|||.|..:      
  Rat   430 PPTLSRVAPEKADEAEKGVPWPASLTPALPSTPVSKNFMVRCKNLRFTMDLSRNNLVTIKPEMFV 494

  Fly   360 SINHLPAKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRM 424
            :::||..    |.:|.|.|....|               |:|:.      ||.|    || ::.:
  Rat   495 NLSHLQC----LSLSHNCIAQAVN---------------GSQFL------PLTN----LK-VLDL 529

  Fly   425 KSAEMKPMFLHSLTELPK---GFLKFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMS 486
            ...::......|.:|||:   ..|.:..:.|...|:.....:|.|..: ||::....|::::.:|
  Rat   530 SYNKLDLYHSKSFSELPQLQALDLSYNSQPFSMQGIGHNFSFLANLSR-LQNLSLAHNDIHSRVS 593

  Fly   487 IYKY---MEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPDIV 548
            ...|   :|:|......|.|.:|                    .:.|         ::|.|    
  Rat   594 SRLYSTSVEYLDFSGNGVGRMWD--------------------EEDL---------YLYFF---- 625

  Fly   549 ARNSRLMGKQNMSSPMELHLSKNNISNI---TIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNS 610
                     |::.|.:.|.||:|.:..:   .:..|||.|..|..|.|:|...:...|::| .|.
  Rat   626 ---------QDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFL-PNL 680

  Fly   611 IKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDC 675
            ....|:||          :|..| .:..|.....|::.::|......|.         |:|.   
  Rat   681 RDLDLAGN----------LLKAL-TNGTLPNGTLLQKLDVSSNSIVFVV---------PAFF--- 722

  Fly   676 RGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLD---NPWSCSCNDIEKINF 737
                     :|:..:..|:|.:|.|..:   :||......:.|.:||   ||..|:|. ...::.
  Rat   723 ---------ALAVELKEVNLSHNILKTV---DRSWFGPIVMNLTVLDVSSNPLHCACG-APFVDL 774

  Fly   738 MKSVSSSIVDFTE-IKCSNGEKL----VSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQ 797
            :..|.:.:..... :||.:..:|    :......:|..|:.......:||:|  :|:..::    
  Rat   775 LLEVQTKVPGLANGVKCGSPRQLQGRSIFAQDLRLCLDDVLSRDCFGLSLLA--VAVGTVL---- 833

  Fly   798 PVL-------VWFYEHGVCLS----LSAKRELDKDKRFDAFLAFTHKDEALLE----EFVDRLE- 846
            |:|       ||:..| :||:    |:..|...:...:|||:.|.....|:.:    |...||| 
  Rat   834 PLLQHLCGWDVWYCFH-LCLAWLPLLTRGRRSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEE 897

  Fly   847 -RGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDR 910
             |||...:||...||||.|:::.:.:..||..||:.:.::......|...|..|.||......||
  Rat   898 RRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDKVSGLLRTSFLLAQQRLLEDR 962

  Fly   911 CKRLI-VVLYPNVKNFDSLDSELRTYMAFNTYLERSHPNFW 950
            ...:: |:|.|        |:....|:.....|.|....||
  Rat   963 KDVVVLVILRP--------DAHRSRYVRLRQRLCRQSVLFW 995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 leucine-rich repeat 325..345 CDD:275378 8/42 (19%)
leucine-rich repeat 346..367 CDD:275378 8/37 (22%)
leucine-rich repeat 563..583 CDD:275378 5/22 (23%)
leucine-rich repeat 585..610 CDD:275378 7/24 (29%)
leucine-rich repeat 611..622 CDD:275378 3/10 (30%)
TIR 823..960 CDD:214587 39/135 (29%)
Tlr9NP_937764.1 leucine-rich repeat 43..64 CDD:275380
LRR_8 63..135 CDD:290566 16/70 (23%)
leucine-rich repeat 65..88 CDD:275380 5/16 (31%)
leucine-rich repeat 89..124 CDD:275380 9/41 (22%)
LRR_RI 123..373 CDD:238064 46/256 (18%)
leucine-rich repeat 125..144 CDD:275380 5/18 (28%)
LRR_8 143..211 CDD:290566 9/67 (13%)
leucine-rich repeat 145..168 CDD:275380 2/22 (9%)
leucine-rich repeat 169..200 CDD:275380 6/30 (20%)
LRR_8 199..254 CDD:290566 3/54 (6%)
leucine-rich repeat 201..221 CDD:275380 2/19 (11%)
leucine-rich repeat 222..245 CDD:275380 1/22 (5%)
leucine-rich repeat 246..285 CDD:275380 5/38 (13%)
LRR_8 284..344 CDD:290566 17/59 (29%)
leucine-rich repeat 286..309 CDD:275380 5/22 (23%)
LRR_RI 310..556 CDD:238064 63/299 (21%)
leucine-rich repeat 310..335 CDD:275380 4/24 (17%)
leucine-rich repeat 336..365 CDD:275380 9/33 (27%)
leucine-rich repeat 393..416 CDD:275380 5/33 (15%)
leucine-rich repeat 477..498 CDD:275380 5/20 (25%)
LRR_RI <490..692 CDD:238064 57/285 (20%)
LRR_8 497..556 CDD:290566 19/88 (22%)
leucine-rich repeat 499..523 CDD:275380 10/48 (21%)
leucine-rich repeat 524..547 CDD:275380 5/23 (22%)
leucine-rich repeat 548..577 CDD:275380 5/28 (18%)
leucine-rich repeat 578..630 CDD:275380 14/93 (15%)
leucine-rich repeat 601..618 CDD:275380 5/36 (14%)
LRR_8 629..690 CDD:290566 19/71 (27%)
leucine-rich repeat 631..655 CDD:275380 6/23 (26%)
leucine-rich repeat 656..679 CDD:275380 7/23 (30%)
leucine-rich repeat 680..703 CDD:275380 6/33 (18%)
LRR_8 704..763 CDD:290566 16/82 (20%)
leucine-rich repeat 704..727 CDD:275380 6/43 (14%)
leucine-rich repeat 728..746 CDD:275380 6/20 (30%)
leucine-rich repeat 753..774 CDD:275380 7/21 (33%)
TIR_2 870..1013 CDD:304906 39/134 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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