DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and lgi1a

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_955921.2	Gene:	lgi1a / 323011	ZFINID:	ZDB-GENE-030131-1731	Length:	537	Species:	Danio rerio

Alignment Length:	152	Identity:	38/152 - (25%)
Similarity:	61/152 - (40%)	Gaps:	44/152 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 RQMAAPCPHKCECCYSRDSLILKIDCRN--KFVYNFP-DIVARNSRLMG-----KQNMSSPMELH 567
            |:.::.||..|.|  |:|:.:    |.|  ....:|| |:::.:....|     |::......||
Zfish    22 RRRSSRCPAPCTC--SKDNAL----CANTGAIPRSFPQDVISLSFVKSGFTEIPKESFIHTPALH 80

  Fly   568 L------SKNNISNITIAMLP-----------------------KELRFLDLRFNNLVTLDDKVL 603
            |      |.::|:......||                       |.|..|.|.:|||.||...:.
Zfish    81 LLLFTANSFDSINEDAFLGLPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLETLPKDLF 145

  Fly   604 SYLKKNSIKTKLSGNPWNCDCK 625
            ..::..: |..|.||.::||||
Zfish   146 KGMEALT-KVDLRGNLFSCDCK 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378
		leucine-rich repeat	346..367	CDD:275378
		leucine-rich repeat	563..583	CDD:275378	7/48 (15%)
		leucine-rich repeat	585..610	CDD:275378	8/24 (33%)
		leucine-rich repeat	611..622	CDD:275378	4/10 (40%)
		TIR	823..960	CDD:214587
lgi1a	NP_955921.2	LRR_8	57..113	CDD:290566	9/55 (16%)
		LRR_4	77..120	CDD:289563	7/42 (17%)
		leucine-rich repeat	79..102	CDD:275378	6/22 (27%)
		LRR_8	101..161	CDD:290566	14/60 (23%)
		LRR_4	101..141	CDD:289563	9/39 (23%)
		leucine-rich repeat	103..126	CDD:275378	0/22 (0%)
		leucine-rich repeat	127..150	CDD:275378	8/22 (36%)
		leucine-rich repeat	151..163	CDD:275378	4/12 (33%)
		TPKR_C2	159..207	CDD:301599	5/8 (63%)
		EPTP	211..252	CDD:281697
		EPTP	257..298	CDD:281697
		EPTP	303..349	CDD:281697
		EPTP	352..394	CDD:281697
		EPTP	399..441	CDD:281697
		EPTP	444..485	CDD:281697
		EPTP	490..530	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574205
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930