DRSC/TRiP Functional Genomics Resources

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Protein Alignment MstProx and Tlr2

DIOPT Version :10

Sequence 1:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster
Sequence 2:XP_008759324.3 Gene:Tlr2 / 310553 RGDID:735138 Length:831 Species:Rattus norvegicus


Alignment Length:942 Identity:200/942 - (21%)
Similarity:332/942 - (35%) Gaps:311/942 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 IRAVDYLRQLGVETVTRFENQINSFKVIERDVHYINGPKSLKIIIQSNLYLNEI----------I 142
            :||...||.|.:|:        :....||.|..|..|  ||:.:..||.:|:.:          :
  Rat   119 LRACVNLRVLTLES--------SGINTIEGDAFYSLG--SLEHLDLSNNHLSSLSSSWFRPLSSL 173

  Fly   143 EYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQIENLSTKPFAQFINLKR 207
            :|:|        ::.|.|:|:.      :..:|:..::|::|     ::.|:.|     |..::|
  Rat   174 KYLN--------LMGNPYRTLG------ETSLFSNLTNLQNL-----RVGNVDT-----FSEIRR 214

  Fly   208 MVLTNCTVRNLTFLRTLQKSLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICTH- 271
            :.....|            ||..||:.:.:      ..|:.|.....:|:...       :..| 
  Rat   215 IDFAGLT------------SLNELEIQVLS------LGNYESRSLQSIRDIYH-------LTLHL 254

  Fly   272 KNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGG--VKLNFSNNSLSQ 334
            ....|:.||       ....|..:..|||.  .:||...|...|.:.....  .||.|.|..|: 
  Rat   255 SESAFLLGI-------FADILSSVRYLELR--DTNLARFQFSELSVDEINSPMKKLAFRNADLT- 309

  Fly   335 LPTMTLPGYKLVKRLDVSRNRLTNLSINHLPAKLDYLDVSFNE--IINMGN------DVIKYL-- 389
                           |.|.|.|..|    |...|:.::|.|:.  :..:||      ||::.|  
  Rat   310 ---------------DKSFNELLKL----LRYILELMEVEFDHCTLNGVGNFNPSESDVVRELGK 355

  Fly   390 -RTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFI 453
             .||.|......|:.:..|...:.:....:|.|    :.|...:||     :|..|.:.| |...
  Rat   356 VETVTIRSLHIPQFYLFYDLSTVYSLLEKVKRI----TVENSKVFL-----VPCSFSQHL-KSLE 410

  Fly   454 WLGVRKQ---EYYLINEE-----QLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYI 510
            :|.:.:.   |.||.|..     ..|||:....|:|.:|           ||...:     |..:
  Rat   411 FLDLSENLMVEEYLKNSACEGGWPSLQSLVLSQNHLRSI-----------RKTAEI-----LLTL 459

  Fly   511 RQMAA---------PCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMEL 566
            :.:.|         |.|..|:                     :|          ||...     |
  Rat   460 KNLTALDISKNSFQPMPDSCQ---------------------WP----------GKMRF-----L 488

  Fly   567 HLSKNNISNITIAMLPKELRFLDLRFNNL----VTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSR 627
            :||...|..:. ..:|:.|..||:..|||    :.|......|:.:|.:|               
  Rat   489 NLSSTGIQAVK-TCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLK--------------- 537

  Fly   628 SVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTY 692
                            ||...::.|                           :||:         
  Rat   538 ----------------TLPEASLFP---------------------------VLQV--------- 550

  Fly   693 VDLRNNNLTALSQKNRSSIENRSLKLHLL---DNPWSCSCNDIEKINFMKSVSSSIVDFTE-IKC 753
            :.:|.|.::..|:....|..    ||..|   ||.:.|||..:..|....::...:||:.: ..|
  Rat   551 MKIRENAISTFSKDQLGSFP----KLETLEAGDNHFICSCELLSFILERPALVHVLVDWPDSYLC 611

  Fly   754 SNGEKLVSINQHIVCPSDLFYYLALAIS-----LVATIIALNFL------IWFRQPVLVWFYEHG 807
            .:..:|.........||.|..:.|..:|     |:..|:.|..|      :|:.:.:..|     
  Rat   612 DSPPRLHGQRLQDARPSVLECHQAALVSGVCCALLLLILLLGALCYHFHGLWYLRMMWAW----- 671

  Fly   808 VCLSLSAKRELDK----DKRFDAFLAFTHKDEALLEE-FVDRLERGRPRFQLCFYLRDWLAGESI 867
                |.|||:..|    |..:|||::::.:|...:|. .|.:||...|.|:||.:.||::.|:.|
  Rat   672 ----LRAKRKPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQLENSDPPFKLCLHKRDFVPGKWI 732

  Fly   868 PDCIGQSIKDSRRIIVLMTENFMNSTWGRLE-----FRLALHATSRDRCKRLIVVLYP-NVKNFD 926
            .|.|..||:.|.:.:.:::|||:.|.|.:.|     |||    ...:....::|:|.| ..|...
  Rat   733 IDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRL----FDENNDAAILVLLEPIEKKAIP 793

  Fly   927 SLDSELRTYMAFNTYL-----ERSHPNFWNKL 953
            ....:||..|...|||     |.....||..|
  Rat   794 QRFCKLRKIMNTKTYLEWPLDEGQREVFWANL 825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstProxNP_649719.2 PRK15370 <315..>398 CDD:185268 23/95 (24%)
leucine-rich repeat 325..345 CDD:275378 4/19 (21%)
leucine-rich repeat 346..367 CDD:275378 6/20 (30%)
TIR 823..960 CDD:214587 44/143 (31%)
Tlr2XP_008759324.3 LRR <86..337 CDD:443914 62/305 (20%)
leucine-rich repeat 101..124 CDD:275378 2/4 (50%)
leucine-rich repeat 125..148 CDD:275378 9/32 (28%)
leucine-rich repeat 149..172 CDD:275378 4/22 (18%)
leucine-rich repeat 173..197 CDD:275378 6/37 (16%)
leucine-rich repeat 229..249 CDD:275380 3/25 (12%)
leucine-rich repeat 250..270 CDD:275380 5/26 (19%)
LRR <382..>598 CDD:443914 63/349 (18%)
leucine-rich repeat 409..435 CDD:275380 5/25 (20%)
leucine-rich repeat 436..461 CDD:275380 9/40 (23%)
leucine-rich repeat 462..484 CDD:275380 5/52 (10%)
leucine-rich repeat 485..505 CDD:275380 5/25 (20%)
leucine-rich repeat 506..525 CDD:275380 7/18 (39%)
leucine-rich repeat 526..547 CDD:275380 6/78 (8%)
leucine-rich repeat 548..571 CDD:275380 6/35 (17%)
LRRCT 580..633 CDD:214507 12/52 (23%)
TIR 687..831 CDD:214587 44/143 (31%)

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