DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and Cd180

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001099875.1	Gene:	Cd180 / 294706	RGDID:	1308170	Length:	662	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	162/784 - (20%)
Similarity:	262/784 - (33%)	Gaps:	275/784 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NLYLNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGF---QIENLST 196
            :|.|:||...:..:|::: |...||..|::....          |.|.:|||:..   ||..:..
  Rat    41 HLGLSEIPGTLPNSTESL-EFSFNALPTIQKTTF----------SRLVNLTFLDLTRCQIYWIHE 94

  Fly   197 KPFAQFINLKRMVLTNCTVRNLTFLR----TLQKSLEHLELDIDNEVDLKYF--TNFSSLKFMKV 255
            ..|.....|:.:||   |...|.|:.    |..|:|:||           :|  |..||::|:.|
  Rat    95 DTFQSQHRLETLVL---TANPLIFMAETALTGPKALKHL-----------FFIQTGISSIEFIPV 145

  Fly   256 RNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYI----IDDLELNIDCSNLGLLQIPPLP 316
            .:                            .|..:.||:    |..:.|             |..
  Rat   146 HS----------------------------QKALESLYLGSNHISSIRL-------------PKD 169

  Fly   317 IPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSR-NRLTNLSINHLPAKLDYLDVSFNEIIN 380
            .|:.....|:|.||::..|           .:.|||. .:.||||:|                :|
  Rat   170 FPTEKLKVLDFQNNAIHHL-----------SKEDVSSLQQATNLSLN----------------LN 207

  Fly   381 MGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFL 445
             |||:...  ....||.|..|         .|||.....|::..|..:...:
  Rat   208 -GNDITGI--EPGAFKSTVFQ---------SLNFGGTQSLLVIFKGLQNSTI------------- 247

  Fly   446 KFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFY- 509
                 ..:|||..:.   :.::|.:..||...|..    ||:.:.....|.   |.|...:.||
  Rat   248 -----QSLWLGTFED---IDDDEDISSSMFEGLCE----MSVERINLQKHH---FFNITSNTFYC 297

  Fly   510 ---IRQMAAPCPHKCEC------CYSRDSLILKIDCRNKF-------VYNFPD-----IVARNSR 553
               ::::.....|..|.      ......|:|.   .|||       ..|||.     |.....|
  Rat   298 FSGLQELDLTATHLTELPSGIVGLSKLKKLVLS---ANKFENLCQISASNFPSLTHLYIKGNTKR 359

  Fly   554 L-MGK---QNMSSPMELHLSKNNISNITIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTK 614
            | :|.   :.:....||.||.::|......         :|:..||..|....|||.:...::|:
  Rat   360 LELGSGCLETLEHLRELDLSHDDIETSDCC---------NLQLRNLSHLQSLNLSYNEPLGLRTE 415

  Fly   615 LSGNPWNCDCKSRSVLSI------LRD-HEPLEYDVTLKRCNISPTDCPDVCVC------CLDNL 666
            ...     :|....:|.:      ::| ..|.:....||..|:|.      |:.      .||.|
  Rat   416 AFK-----ECPQLELLDLAFTRLHVKDAQSPFQNLHLLKVLNLSH------CLLGSSNQHLLDGL 469

  Fly   667 -----------TWPSFIVD----CRGEGLLQMPSLS---------------SRVTYVDLRNNNLT 701
                       .:|:..:.    .:..|.|::..||               ..:.:|||.:|.||
  Rat   470 PALRHLNLQGNRFPNGNIQKTNPLQALGSLEILILSFCDLSSIDHQAFINLKIMNHVDLSHNRLT 534

  Fly   702 -----ALSQ---------KNRSSIENRSL--------KLHLLDNPWSCSCNDIEKINFMKSVSSS 744
                 |||.         .||.||...||        .::|..||..|:|::|..:.:.|.....
  Rat   535 SSSIEALSHLKGIYLNLASNRISIIPPSLLPVLSQQRTINLRQNPLDCTCSNIYFLEWYKENMQK 599

  Fly   745 IVDFTEIKCSNGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFR-------QPVLVW 802
            :.|..:..|:|...|..:.     .||:.  |:.:::.|.....:.||:.|.       :..|.|
  Rat   600 LEDIEDTFCANPPLLRGVK-----VSDVM--LSCSMAAVGIFFLIVFLLLFAVLLIFAVKRFLRW 657

  Fly   803 FYEH 806
            .|:|
  Rat   658 KYQH 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	5/19 (26%)
		leucine-rich repeat	346..367	CDD:275378	8/21 (38%)
		leucine-rich repeat	563..583	CDD:275378	5/19 (26%)
		leucine-rich repeat	585..610	CDD:275378	7/24 (29%)
		leucine-rich repeat	611..622	CDD:275378	1/10 (10%)
		TIR	823..960	CDD:214587
Cd180	NP_001099875.1	leucine-rich repeat	55..78	CDD:275380	7/33 (21%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..126	CDD:275380	7/25 (28%)
		leucine-rich repeat	127..150	CDD:275380	9/61 (15%)
		leucine-rich repeat	151..174	CDD:275380	6/35 (17%)
		leucine-rich repeat	175..195	CDD:275380	7/30 (23%)
		leucine-rich repeat	196..223	CDD:275380	11/45 (24%)
		leucine-rich repeat	224..244	CDD:275380	6/28 (21%)
		leucine-rich repeat	277..300	CDD:275380	5/25 (20%)
		LRR_RI	301..480	CDD:238064	39/201 (19%)
		leucine-rich repeat	301..323	CDD:275380	2/21 (10%)
		LRR_8	322..383	CDD:290566	16/63 (25%)
		leucine-rich repeat	324..347	CDD:275380	7/25 (28%)
		leucine-rich repeat	348..372	CDD:275380	4/23 (17%)
		LRR_8	372..433	CDD:290566	15/74 (20%)
		leucine-rich repeat	373..398	CDD:275380	8/33 (24%)
		leucine-rich repeat	399..422	CDD:275380	6/27 (22%)
		LRR_8	421..482	CDD:290566	11/66 (17%)
		leucine-rich repeat	423..447	CDD:275380	3/23 (13%)
		leucine-rich repeat	448..471	CDD:275380	8/28 (29%)
		leucine-rich repeat	472..498	CDD:275380	1/25 (4%)
		LRR_8	498..556	CDD:290566	13/57 (23%)
		leucine-rich repeat	499..522	CDD:275380	3/22 (14%)
		leucine-rich repeat	523..546	CDD:275380	9/22 (41%)
		TPKR_C2	578..627	CDD:301599	13/55 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910