DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and Tlr4

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_062051.2	Gene:	Tlr4 / 29260	RGDID:	3870	Length:	835	Species:	Rattus norvegicus

Alignment Length:	940	Identity:	194/940 - (20%)
Similarity:	357/940 - (37%)	Gaps:	279/940 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LNEIIEYINKTT-----DNVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGF-------- 189
            ||..||.:...|     .|:::|..:...:.:|    || |.||....|||.:|..|
  Rat    25 LNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKN----LD-LSFNPLKILRSYSFSNFSQLQWLDL 84

  Fly   190 ---QIENLSTKPFAQFINLKRMVLTNCTVR--------------NLTFLRTLQKSLEHLELDIDN 237
               :||.:..|.:.....|..:|||...::              ||..:.|...|||...  |..
  Rat    85 SRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFH--IGQ 147

  Fly   238 EVDLK----------------YFTNFSSLKFMKVR-NYIPNKNFTALICTHKNCNFIRGINGLEC 285
            .:.||                ||:|.::|:.:.:. |||..       .:.|:..|:|     |.
  Rat   148 LISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVDLSYNYIQT-------ISVKDLQFLR-----EN 200

  Fly   286 PKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKL-------NFSNNSLSQLPTMTLPG- 342
            |:          :.|::|   |.|..|..:...::.|::|       ||:::::.::....:.|
  Rat   201 PQ----------VNLSLD---LSLNPIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGL 252

  Fly   343 ---------YKLVKRLDVSRNR-----LTNLSINHLPAKLDYLDVSFNEIINMGNDVIKYLRTVP 393
                     :|..:.|: |.:|     |.|:||:..  :|.|::...::|.|     :..|..:.
  Rat   253 HVHRLILGEFKNERNLE-SFDRSVMEGLCNVSIDEF--RLTYINHFSDDIYN-----LNCLANIS 309

  Fly   394 IFKQTGNQWTIHCDDKPLLNFFRHLK----LIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIW 454
            ....||    :|.  |.:.:..||.|    .|||   ..:||        .||..|.||
  Rat   310 AMSFTG----VHI--KHIADVPRHFKWQSLSIIR---CHLKP--------FPKLSLPFL------ 351

  Fly   455 LGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPH 519
                                                ..|    .:..||| |:.: .|:|.|...
  Rat   352 ------------------------------------KSW----TLTTNRE-DISF-GQLALPSLR 374

  Fly   520 KCECCYSRDSLILKIDC------RNKFVY---NFPDIVARNSRLMGKQNMSSPMELHLSKNNISN 575
            ..:  .||:::..:..|      .|...|   :|..::..::..||.:.:......|.:...::.
  Rat   375 YLD--LSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTE 437

  Fly   576 ITIAMLPKELRFLDLRFNNL-VTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPL 639
            .::.:..::|.:||:.:.|. :..|...|..:..|::  |::||.:.
  Rat   438 FSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTL--KMAGNSFK------------------ 482

  Fly   640 EYDVTLKRCNISPTDCP--DVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTA 702
              |.||.....:.|:..  |:..|.|:.::...|             ....|:..:::.:|||..
  Rat   483 --DNTLSNVFTNTTNLTFLDLSKCQLEQISRGVF-------------DTLYRLQLLNMSHNNLLF 532

  Fly   703 LSQKNRSSIEN----------------------RSLKL-HLLDNPWSCSCNDIEKINFMKSVSSS 744
            |...:...:.:                      :||.: :|.:|..:|.|.....:.::|.....
  Rat   533 LDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMF 597

  Fly   745 IVDFTEIKCSN----GEKLVSINQHIVCPSDLFYYLALAISLVATII--ALNFLIWFRQPVLVWF 803
            :|:..::||::    ...||....:..|   ..|...:::|:|:.::  .:.|||:.       |
  Rat   598 LVNVEQMKCASPIDMKASLVLDFTNSTC---YIYKTIISVSVVSVLVVATVAFLIYH-------F 652

  Fly   804 YEHGVCLSLSAKRELDKDKRFDAFLAFTHKDEA-LLEEFVDRLERGRPRFQLCFYLRDWLAGESI 867
            |.| :.|....|:....:..:|||:.::.::|. :..|.|..||.|.||||||.:.||::.|.:|
  Rat   653 YFH-LILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAI 716

  Fly   868 -PDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLA---LHATSRDRCKRLIVVLYPNVKNFDSL 928
             .:.|.:....||::||:::.:|:.|.|...|:.:|   ...:||...  :.:||....|:....
  Rat   717 AANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGI--IFIVLEKVEKSLLRQ 779

  Fly   929 DSELRTYMAFNTYLE-----RSHPNFWNKL 953
            ..||...::.|||||     .....||.:|
  Rat   780 QVELYRLLSRNTYLEWEDNALGRHIFWRRL 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	4/36 (11%)
		leucine-rich repeat	346..367	CDD:275378	7/25 (28%)
		leucine-rich repeat	563..583	CDD:275378	1/19 (5%)
		leucine-rich repeat	585..610	CDD:275378	6/25 (24%)
		leucine-rich repeat	611..622	CDD:275378	3/10 (30%)
		TIR	823..960	CDD:214587	44/141 (31%)
Tlr4	NP_062051.2	PLN00113	23..>456	CDD:215061	106/537 (20%)
		LRR 1	54..75		10/25 (40%)
		leucine-rich repeat	58..78	CDD:275380	10/20 (50%)
		LRR 2	78..99		3/20 (15%)
		leucine-rich repeat	79..102	CDD:275380	3/22 (14%)
		LRR 3	102..123		4/20 (20%)
		leucine-rich repeat	103..126	CDD:275380	4/22 (18%)
		LRR 4	126..147		7/22 (32%)
		leucine-rich repeat	127..150	CDD:275380	7/24 (29%)
		LRR 5	150..171		3/20 (15%)
		leucine-rich repeat	151..175	CDD:275380	5/23 (22%)
		LRR 6	175..198		6/29 (21%)
		leucine-rich repeat	176..204	CDD:275380	9/49 (18%)
		LRR 7	204..224		5/22 (23%)
		leucine-rich repeat	205..226	CDD:275380	6/23 (26%)
		LRR 8	226..247		3/20 (15%)
		leucine-rich repeat	256..310	CDD:275380	13/61 (21%)
		LRR 9	372..381		1/10 (10%)
		leucine-rich repeat	373..398	CDD:275380	3/26 (12%)
		LRR 10	398..420		4/21 (19%)
		leucine-rich repeat	399..421	CDD:275380	4/21 (19%)
		LRR 11	421..442		1/20 (5%)
		leucine-rich repeat	422..446	CDD:275380	1/23 (4%)
		LRR 12	446..467		5/20 (25%)
		leucine-rich repeat	447..470	CDD:275380	6/22 (27%)
		LRR 13	470..491		7/42 (17%)
		leucine-rich repeat	471..495	CDD:275380	7/45 (16%)
		LRR_8	494..554	CDD:404697	10/72 (14%)
		LRR 14	495..516		4/33 (12%)
		leucine-rich repeat	496..519	CDD:275380	4/35 (11%)
		LRR 15	519..540		5/20 (25%)
		leucine-rich repeat	520..543	CDD:275380	4/22 (18%)
		LRR 16	543..564		0/20 (0%)
		leucine-rich repeat	544..567	CDD:275380	0/22 (0%)
		TIR	672..813	CDD:214587	44/140 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920