DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MstProx and Tlr5

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001139300.1	Gene:	Tlr5 / 289337	RGDID:	631351	Length:	871	Species:	Rattus norvegicus

Alignment Length:	869	Identity:	178/869 - (20%)
Similarity:	326/869 - (37%)	Gaps:	231/869 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 RDVHYINGPKSLKIIIQSN----LYLNEIIEYINKTTDNVNEIIINAYKTVENQQIALDNLIFNG 177
            ||.::.|.....::.:.:|    |:|:...:.::..:| :|......:...|::...|..
  Rat   149 RDAYFRNLNSLARLDLSANEIHSLHLHSSFQELSSLSD-INFSFNRIFTLCEDELQPLQG----- 207

  Fly   178 KSHLRSLTFIGFQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTLQKSLEHLELDIDNEVDLK 242
                |:|:|.|.:..:|.::.|..:        ..|  ||.  ||.::  ||.|:|. :|.....
  Rat   208 ----RTLSFFGLKSTSLFSRVFVDW--------EAC--RNP--LRGIR--LETLDLS-ENGWTAA 253

  Fly   243 YFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNL 307
            ...|||        :.|...:.::||.|:.......|...::.|.......:.....|.:|.|:.
  Rat   254 ILGNFS--------HTIQGSHISSLILTYHIMGSGFGFQNIKDPDQSTFASLARSSVLQLDLSHG 310

  Fly   308 GLLQIPPLPIPSYGGV-KLNFSNNSLSQLPTMTLPGYKLVKRLDVSRN---RLTNLSINHLPAKL 368
            .:..:.|....:...: |||.:.|.::::......|...::.|::|.|   .|.|.:...||: :
  Rat   311 YIFSLNPRLFETLKDLKKLNLAFNKINKISDYAFHGLDSLQILNLSYNLLGELYNSNFYGLPS-I 374

  Fly   369 DYLDVSFNEIINMGNDVIKYLRTVPIFKQTGNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMF 433
            .|||:..|.|..:.:...:.|:.:.......|.                ||.|..:.|.:|..:.
  Rat   375 AYLDLQRNHIGIIQDRTFRLLKKLQTLDLRDNA----------------LKTIGFIPSVQMVLLG 423

  Fly   434 LHSLTELPKGFLKFLGKHFIWLGVRKQE-----YYLINEEQLLQSMHRKLNNLNTIMSI-YKYME 492
            .:.||.||  .::|.. :||.|.....|     |:|:.... ||.:....|.|::..:: |...:
  Rat   424 SNKLTHLP--HVRFTA-NFIELSENGLENLSDLYFLLRIPG-LQFLILNQNRLSSCSNVDYAPSQ 484

  Fly   493 WLHRKLIFVNREYDLFYIRQMAAPCPHKCECCY------SRDSLILKIDCRNKFVYNF--PDIVA 549
            .|..:.:|:...     :.|:|    .:...|:      ||    |:|...|....||  |.|.
  Rat   485 NLSLEQLFLAEN-----MLQLA----WETGLCWDIFKGLSR----LQILYLNNNYLNFLPPGIF- 535

  Fly   550 RNSRLMGKQNMSSPMELHLSKNNISNITIAMLPKELRFLDLRFNNLVTLDDKVLSYLKKNSIKTK 614
                    ..:.:...|.||.|.::.::...||..|..||:..|.|.:.|..:.|.|:...|
  Rat   536 --------NGLVALRMLSLSANRLTMLSPGSLPANLEILDISRNQLFSPDPGLFSSLRALDI--- 589

  Fly   615 LSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNI----SPTDCPDVCVCCLDNLTWPSFIVDC 675
             :.|.:.|||:..:.:            |.|.:.|:    ||.|     |.|:    :|:.::.
  Rat   590 -THNEFICDCELSTFI------------VWLNQTNVTLFGSPAD-----VYCM----YPNSLLG- 631

  Fly   676 RGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLDNPWSCSCNDIEKINFMKS 740
                                             ||:.|.|.|          .|::.|.:   :|
  Rat   632 ---------------------------------SSLYNISTK----------DCDEEEAV---RS 650

  Fly   741 VSSSIVDFTEIKCSNGEKLVSINQHIVCPSDLFYYLALAISLVATIIALNFLIWFRQPVLVWFYE 805
            ::.|:                   .|:|.      :.|.:.||.|:|...|
  Rat   651 LNFSL-------------------FILCT------VTLTLFLVITLIVTKF-------------- 676

  Fly   806 HGVCLSL--SAKRELDKDK---------RFDAFLAFTHKD-----EALLEEFVDRLERGRPRFQL 854
            .|:|...  :.::.:.|.|         |:||:..|:.||     .|||:. :|.....:.|.:|
  Rat   677 RGICFLCFKTIQKLMFKGKFRNPEPSAYRYDAYFCFSSKDFEWAQNALLKH-LDAQYSSQNRLRL 740

  Fly   855 CFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLY 919
            ||..||::.||:....|..::..||:.:.|::.:|:...|....||.|......|..:.||||:.
  Rat   741 CFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRCLSDLKRVLIVVVV 805

  Fly   920 PNVKNFDSLDSE-LRTYMAFNTYL 942
            .::..:..:..| :|.::....||
  Rat   806 GSLPQYQLMRHETIRGFLQKQQYL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	4/19 (21%)
		leucine-rich repeat	346..367	CDD:275378	7/23 (30%)
		leucine-rich repeat	563..583	CDD:275378	5/19 (26%)
		leucine-rich repeat	585..610	CDD:275378	8/24 (33%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	36/126 (29%)
Tlr5	NP_001139300.1	LRR_8	<96..143	CDD:404697
		PLN00113	<108..>384	CDD:215061	55/268 (21%)
		leucine-rich repeat	109..132	CDD:275380
		leucine-rich repeat	133..158	CDD:275380	3/8 (38%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..217	CDD:275380	8/42 (19%)
		leucine-rich repeat	240..301	CDD:275380	14/69 (20%)
		leucine-rich repeat	302..325	CDD:275380	4/22 (18%)
		LRR	314..>578	CDD:227223	66/306 (22%)
		LRR_8	326..384	CDD:404697	16/58 (28%)
		leucine-rich repeat	326..349	CDD:275380	5/22 (23%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
		leucine-rich repeat	374..397	CDD:275380	6/22 (27%)
		leucine-rich repeat	398..432	CDD:275380	10/51 (20%)
		leucine-rich repeat	433..461	CDD:275380	7/28 (25%)
		leucine-rich repeat	462..487	CDD:275380	5/24 (21%)
		leucine-rich repeat	488..516	CDD:275380	4/36 (11%)
		leucine-rich repeat	517..540	CDD:275380	7/31 (23%)
		leucine-rich repeat	541..559	CDD:275380	4/17 (24%)
		leucine-rich repeat	563..586	CDD:275380	8/22 (36%)
		PCC	567..>645	CDD:188093	26/146 (18%)
		TIR	706..856	CDD:396246	35/125 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920