DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and Tlr2

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_006501523.1	Gene:	Tlr2 / 24088	MGIID:	1346060	Length:	794	Species:	Mus musculus

Alignment Length:	911	Identity:	189/911 - (20%)
Similarity:	328/911 - (36%)	Gaps:	286/911 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PKSLKIIIQS-NLYLNEI-------------IEYINKTTDNVNEIIINAYKTV---------ENQ 166
            |..|...::| :|..|:|             ::.:...:..:|.|..:|:.::         :|.
Mouse    57 PSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNH 121

  Fly   167 QIALDNLIFNGKSHLRSLTFIGFQIENLS-TKPFAQFINLKRMVLTNCTVRNLTFLRTLQ----K 226
            ..:|.:..|...|.|:.|..:|...:.|. |..|....||:.:.:.|  |...:.:|.:.    .
Mouse   122 LSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGN--VETFSEIRRIDFAGLT 184

  Fly   227 SLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICTHKNCNFIRGINGLECPKLCQC 291
            ||..||                 :|.:.:|||           ..::...||.|:.|.. .|.:.
Mouse   185 SLNELE-----------------IKALSLRNY-----------QSQSLKSIRDIHHLTL-HLSES 220

  Fly   292 LYIID---DL-----ELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKR 348
            .::::   |:     .|.:..:||...|..|||:..                  ::.|..||..|
Mouse   221 AFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDE------------------VSSPMKKLAFR 267

  Fly   349 LDVSRNRLTNLSINHLPAKLDYL----DVSFNEIINMG--------NDVIKYL---RTVPIFKQT 398
            ..|    ||:.|.|.|...|.|:    :|.|::....|        :||:..|   .||.|.:..
Mouse   268 GSV----LTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLH 328

  Fly   399 GNQWTIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFLKFLGKHFIWLGVRKQ--- 460
            ..|:.:..|...:.:....:|.|    :.|...:||     :|..|.:.| |...:|.:.:.
Mouse   329 IPQFYLFYDLSTVYSLLEKVKRI----TVENSKVFL-----VPCSFSQHL-KSLEFLDLSENLMV 383

  Fly   461 EYYLINEE-----QLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHK 520
            |.||.|..     ..||::....|:|.::....:.:..| :.|..::...:.|:      |.|..
Mouse   384 EEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTL-KNLTSLDISRNTFH------PMPDS 441

  Fly   521 CECCYSRDSLILKIDCRNKFVYNFPDIVARNSRLMGKQNMSSPMELHLSKNNISNITIAMLPKEL 585
            |:                     :|:          |...     |:||...| .:....:|:.|
Mouse   442 CQ---------------------WPE----------KMRF-----LNLSSTGI-RVVKTCIPQTL 469

  Fly   586 RFLDLRFNNL----VTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLK 646
            ..||:..|||    :.|......|:.:|.:||
Mouse   470 EVLDVSNNNLDSFSLFLPRLQELYISRNKLKT--------------------------------- 501

  Fly   647 RCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSI 711
                    .||..:       :|..:|                   :.:|.|.::..|:....|.
Mouse   502 --------LPDASL-------FPVLLV-------------------MKIRENAVSTFSKDQLGSF 532

  Fly   712 ENRSLKLHLL---DNPWSCSCNDIEKINF---MKSVSSSIVDFTE-IKCSNGEKLVSINQHIVCP 769
            .    ||..|   ||.:.|||   |.::|   ..:::..:||:.: ..|.:..:|.........|
Mouse   533 P----KLETLEAGDNHFVCSC---ELLSFTMETPALAQILVDWPDSYLCDSPPRLHGHRLQDARP 590

  Fly   770 SDLFYYLALAISLVATIIALNFL-----------IWFRQPVLVWFYEHGVCLSLSAKRELDK--- 820
            |.|..:.|..:|.|...:.|..|           :|:.:.:..|         |.|||:..|
Mouse   591 SVLECHQAALVSGVCCALLLLILLVGALCHHFHGLWYLRMMWAW---------LQAKRKPKKAPC 646

  Fly   821 -DKRFDAFLAFTHKDEALLEE-FVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIV 883
             |..:|||::::.:|...:|. .|.:||...|.|:||.:.||::.|:.|.|.|..||:.|.:.:.
Mouse   647 RDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVF 711

  Fly   884 LMTENFMNSTWGRLE-----FRLALHATSRDRCKRLIVVLYP-NVKNFDSLDSELRTYMAFNTYL 942
            :::|||:.|.|.:.|     |||    ...:....::|:|.| ..|.......:||..|...|||
Mouse   712 VLSENFVRSEWCKYELDFSHFRL----FDENNDAAILVLLEPIERKAIPQRFCKLRKIMNTKTYL 772

  Fly   943 E 943
            |
Mouse   773 E 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	1/19 (5%)
		leucine-rich repeat	346..367	CDD:275378	7/20 (35%)
		leucine-rich repeat	563..583	CDD:275378	4/19 (21%)
		leucine-rich repeat	585..610	CDD:275378	8/28 (29%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	41/128 (32%)
Tlr2	XP_006501523.1	internalin_A	<58..>259	CDD:380193	44/249 (18%)
		leucine-rich repeat	65..87	CDD:275378	4/21 (19%)
		LRR_8	87..145	CDD:338972	10/57 (18%)
		leucine-rich repeat	88..111	CDD:275378	3/22 (14%)
		leucine-rich repeat	112..135	CDD:275378	3/22 (14%)
		leucine-rich repeat	136..160	CDD:275378	6/23 (26%)
		leucine-rich repeat	186..212	CDD:275380	10/53 (19%)
		leucine-rich repeat	213..233	CDD:275380	3/20 (15%)
		PRK15370	<350..>568	CDD:185268	60/345 (17%)
		leucine-rich repeat	372..398	CDD:275380	5/25 (20%)
		leucine-rich repeat	399..424	CDD:275380	5/25 (20%)
		leucine-rich repeat	448..468	CDD:275380	5/25 (20%)
		leucine-rich repeat	469..488	CDD:275380	7/18 (39%)
		leucine-rich repeat	489..510	CDD:275380	6/68 (9%)
		leucine-rich repeat	511..534	CDD:275380	5/45 (11%)
		TPKR_C2	543..596	CDD:387596	13/55 (24%)
		TIR	650..794	CDD:214587	41/128 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920