DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MstProx and Tlr6

DIOPT Version :9

Sequence 1:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_030110224.1	Gene:	Tlr6 / 21899	MGIID:	1341296	Length:	806	Species:	Mus musculus

Alignment Length:	838	Identity:	189/838 - (22%)
Similarity:	311/838 - (37%)	Gaps:	270/838 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 DDLELNIDCSNLGLLQIP-PLPIPSYGGVKLNFSNNSLSQL--PTMTLPGYKLVKR--------- 348
            ::||..:|.||..|..:| .||..:..   |:.|.||:|:|  |.::......|.|
Mouse    41 NELESMVDYSNRNLTHVPKDLPPRTKA---LSLSQNSISELRMPDISFLSELRVLRLSHNRIRSL 102

  Fly   349 -------------LDVSRNRLTNLSINHLPAKLDYLDVSFNEIINMGNDVIKYLRTVPIFKQTGN 400
                         ||||.|||.|:|...: |.|.:||:|||:.     ||:      |:.|:.||
Mouse   103 DFHVFLFNQDLEYLDVSHNRLQNISCCPM-ASLRHLDLSFNDF-----DVL------PVCKEFGN 155

  Fly   401 QWTI-----------HCDDKPLLNFFRHLKLII------RMKSAEMKPM------FLH------- 435
            ...:           ..|..|:.:.  ||..|:      .:|..|.:.:      .||
Mouse   156 LTKLTFLGLSAAKFRQLDLLPVAHL--HLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNS 218

  Fly   436 ---------------------------------SLTELPKG--FLKFLGKH-------------F 452
                                             .|:||.:|  .|....:|             |
Mouse   219 LFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQF 283

  Fly   453 IWLGVRKQEY----------------YLINEEQLLQSMHRKLNNLNTIMS---IYKYMEWLHRKL 498
            .|  .|..||                :..:|..|...|...:.|...:.|   :|.....::.|:
Mouse   284 FW--PRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKM 346

  Fly   499 IFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVY-NFPDIVARNSRLMGKQNMSS 562
            :.::   |..:|..:..|.|                   :.|.: ||...|..:|...|...:..
Mouse   347 LSIS---DTPFIHMVCPPSP-------------------SSFTFLNFTQNVFTDSVFQGCSTLKR 389

  Fly   563 PMELHLSKNNISN-ITIAMLPK---ELRFLDLRFNNLVT-LDDKVL----SYLKKNSIKTKLSGN 618
            ...|.|.:|.:.| ..:|::.|   .|..||:..|:|.: ..|:..    |.|..|.....|:|:
Mouse   390 LQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGS 454

  Fly   619 PWNC--------DCKSRSVLSILRDHEPLEYDVTLKRCNI---SPTDCPDVCVCCLDNLTWPSFI 672
            .:.|        |..:..::||.:|...|:   .|:..|:   |.||.|
Mouse   455 VFRCLPPKVKVLDLHNNRIMSIPKDVTHLQ---ALQELNVASNSLTDLP---------------- 500

  Fly   673 VDCRGEGLLQMPSLSSRVTYVDLRNNNLTALSQKNRSSIEN-RSLKLHLLDNPWSCSCNDIEKIN 736
                  |.....|||  |..:|  :|:::..|:....|.:| |||...  :||:.|:|   |..:
Mouse   501 ------GCGAFSSLS--VLVID--HNSVSHPSEDFFQSCQNIRSLTAG--NNPFQCTC---ELRD 550

  Fly   737 FMKS---VSSSIV---------DFTEIKCSNGEKLVSINQH-IVCPSDLFYYLALAISLVATIIA 788
            |:|:   |:..:|         |:.|  .|.|..|...:.. :.|.:.|     |.:::.||::.
Mouse   551 FVKNIGWVAREVVEGWPDSYRCDYPE--SSKGTALRDFHMSPLSCDTVL-----LTVTIGATMLV 608

  Fly   789 L----NFL-IWFRQPVLVWFYEHGVCLSLSAK--------RELDKDKRFDAFLAFTHKDEALLE- 839
            |    .|| ::|..|   | |...:|.....:        .||.::.:|.||::::..|.|.::
Mouse   609 LAVTGAFLCLYFDLP---W-YVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSEHDSAWVKN 669

  Fly   840 EFVDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALH 904
            |.:..||:...|  :|.:.|:::.|:||.:.|...|:.|.:.|.:::.:|:.|.|...|...|.|
Mouse   670 ELLPNLEKDDIR--VCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHH 732

  Fly   905 ATSRDRCKRLIVVLYPNV--KNFDSLDSELRTYMAFNTYLERSHPN-------FWNKL 953
            ....:....||::|...:  .|..|...:||..||..||||  .|.       ||..|
Mouse   733 NLFHEGSDNLILILLEPILQNNIPSRYHKLRALMAQRTYLE--WPTEKGKRGLFWANL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	7/21 (33%)
		leucine-rich repeat	346..367	CDD:275378	11/42 (26%)
		leucine-rich repeat	563..583	CDD:275378	5/20 (25%)
		leucine-rich repeat	585..610	CDD:275378	8/29 (28%)
		leucine-rich repeat	611..622	CDD:275378	2/10 (20%)
		TIR	823..960	CDD:214587	41/141 (29%)
Tlr6	XP_030110224.1	leucine-rich repeat	47..64	CDD:275380	7/16 (44%)
		PLN00113	50..>540	CDD:215061	116/561 (21%)
		leucine-rich repeat	65..88	CDD:275378	7/25 (28%)
		LRR_8	87..144	CDD:404697	18/57 (32%)
		leucine-rich repeat	89..112	CDD:275378	2/22 (9%)
		leucine-rich repeat	113..133	CDD:275378	9/20 (45%)
		leucine-rich repeat	134..158	CDD:275378	12/34 (35%)
		leucine-rich repeat	184..206	CDD:275380	3/21 (14%)
		leucine-rich repeat	207..230	CDD:275380	2/22 (9%)
		leucine-rich repeat	290..314	CDD:275380	3/23 (13%)
		leucine-rich repeat	315..343	CDD:275380	5/27 (19%)
		leucine-rich repeat	344..365	CDD:275380	5/42 (12%)
		leucine-rich repeat	390..415	CDD:275380	6/24 (25%)
		leucine-rich repeat	416..440	CDD:275380	6/23 (26%)
		leucine-rich repeat	441..462	CDD:275380	5/20 (25%)
		leucine-rich repeat	463..485	CDD:275380	5/24 (21%)
		leucine-rich repeat	486..508	CDD:275380	7/43 (16%)
		leucine-rich repeat	510..531	CDD:275380	5/22 (23%)
		LRRCT	540..594	CDD:214507	14/58 (24%)
		TIR	652..791	CDD:214587	41/141 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020